Disorders of Excessive Somnolence (Hypersomnia)

248  relevant articles (25 outcomes, 14 trials/studies) found for this Disease

Hypersomnia; Hypersomnolence; DOES (Disorders of Excessive Somnolence); Excessive Somnolence Disorders; Hypersomnia, Recurrent; Hypersomnolence Disorders; Hypersomnolence Disorders, Primary; Hypersomnolence Disorders, Secondary; Primary Hypersomnolence Disorders; Secondary Hypersomnolence Disorders; DOESs (Disorders of Excessive Somnolence); Excessive Somnolence Disorder; Hypersomnias; Hypersomnias, Recurrent; Hypersomnolence Disorder; Hypersomnolence Disorder, Primary; Hypersomnolence Disorder, Secondary; Primary Hypersomnolence Disorder; Recurrent Hypersomnia; Recurrent Hypersomnias; Secondary Hypersomnolence Disorder; Somnolence Disorder, Excessive; Somnolence Disorders, Excessive

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Narcolepsy
2.	Disorders of Excessive Somnolence (Hypersomnia)
3.	Hyperphagia
4.	Snoring
5.	Sleep Apnea Syndromes (Sleep Apnea)

Experts

1.	Kanbayashi, Takashi: 8 articles (09/2006 - 07/2002)
2.	Nishino, Seiji: 5 articles (11/2005 - 10/2002)
3.	Shimizu, Tetsuo: 4 articles (11/2005 - 08/2003)
4.	Schrader, Harald: 2 articles (08/2007 - 10/2002)
5.	Kubota, Hiroaki: 2 articles (09/2006 - 07/2002)
6.	Mignot, Emmanuel: 2 articles (11/2005 - 10/2002)
7.	Ripley, Beth: 2 articles (11/2005 - 10/2002)
8.	Fenik, Polina: 2 articles (10/2005 - 06/2005)
9.	Veasey, Sigrid C: 2 articles (10/2005 - 06/2005)
10.	Pratico, Domenico: 2 articles (10/2005 - 06/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Disorders of Excessive Somnolence:

1.	modafinil (armodafinil)FDA Link 12/01/2007 - "However, the hypersomnia items on the 31-item Hamilton Depression Scale were significantly more improved with modafinil than placebo" 12/01/2003 - "The addition of the selective psychostimulant modafinil resulted in significant improvement in the hypersomnia, with improvement in functioning" 01/01/2005 - "Modafinil in doses of 100-400 mg was administered as augmentation to ongoing antidepressant therapy in patients with partial response and suffering from hypersomnia" 01/01/2005 - "Modafinil, an atypical wakefulness-promoting agent with an unknown mechanism of action, is used to treat hypersomnolence in these patients" 09/01/1999 - "CONCLUSION: These results suggest the efficiency of modafinil against somnolence and hypersomnia without increasing subsequent sleep." Order ALL the reference details at left...
2.	orexins (orexin)IBA 07/01/2008 - "Dysfunction of the hypocretin system has been reported in MS case reports with attacks of hypothalamic lesions, undetectable cerebrospinal fluid (CSF) hcrt-1 and hypersomnia, but not found during remission in small samples" 08/01/2005 - "Hypersomnia and a decrease of the CNS orexin A improved after corticosteroid therapy" 12/01/2006 - "A twofold decrease in hypocretin-1 was evidenced during the period of hypersomnia in comparison with the asymptomatic interval" 09/01/2006 - "Symptomatic hypersomnia due to orexin deficiency in hypothalamic lesions]" 08/01/2003 - "The levels of hypocretin in the cerebrospinal fluid were reduced when measured 3 weeks (Patient 1) and 2 months (Patient 2) after the appearance of hypersomnia, before the presence of sleep-onset rapid eye movement periods was confirmed" Order ALL the reference details at left...
3.	Antidepressive Agents (Antidepressants)IBA 12/01/2006 - "The comparison between BP-II and UP showed differential phenomenology, such as hypersomnia, increased psychomotor activation, guilt feelings and suicidal thoughts in BP-II. Related data demonstrated the importance of CT in further qualifying of MDE to define a distinct, more severe ("darker") BP-II(1/2) variant of BP-II. Moreover, BP-III, arising from DT and associated with antidepressants, emerged as a valid soft bipolar variant on the basis of the phenomenology of hypomania and bipolar family history" 12/01/1995 - "In addition, all antidepressants may eventually correct depressive hypersomnia, but in these cases, it is evidently preferable to prescribe non-sedative drugs" 08/03/1974 - "Letter: Hypersomnia and MAOI antidepressants." 04/01/1999 - "RESULTS: In comparison with the CSR group, the ISR group had a longer duration of illness, more often used antidepressants, and improved significantly less after treatment with bright light for 6 days, whereas the symptomatology in winter (Montgomery-Asberg Depression Rating Scale plus hypersomnia, hyperphagia, and carbohydrate craving) was similar in the two groups" 12/01/1995 - "However, it is very often of benefit to prescribe psychotropic agents, in particular antidepressants, not only in insomnia but also in certain cases of hypersomnia, parasomnia and dysomnia associated with organic diseases" Order ALL the reference details at left...
4.	Imipramine (Janimine)FDA LinkGeneric 07/01/1979 - "Imipramine treatment for hypersomnia." 01/01/1975 - "Stimulant drugs are effective in the treatment of the sleep attacks of narcolepsy and in treating certain cases of hypersomnia, while imipramine is an effective treatment for the auxillary symptoms of narcolepsy" 07/01/1991 - "Although the relatively poor showing of imipramine warrants close scrutiny, these findings provide further documentation of the utility of MAOIs in patients presenting with anergia, motor retardation, hyperphagia, and/or hypersomnia." 08/01/1999 - "RESULTS: Atypical features of mood reactivity and at least one reversed vegetative symptom of hypersomnia, hyperphagia or weight gain (25.2% patients) were predictive of pharmacotherapy non-responsiveness with imipramine compared to placebo" 03/01/1988 - "Sixty patients with probable atypical depression--defined as meeting Research Diagnostic Criteria for depressive illness, having reactive mood, and having one of four associated symptoms (hyperphagia, hypersomnolence, leaden feeling, and sensitivity to rejection)--took part in a study contrasting phenelzine, imipramine, and placebo" Order ALL the reference details at left...
5.	Sodium Oxybate (gamma Hydroxybutyrate)FDA Link 04/01/1981 - "Sodium gamma-hydroxybutyrate in the treatment of essential hypersomnia]" 12/01/2008 - "Sodium oxybate is currently approved by the Food and Drug Administration for the treatment of narcolepsy with cataplexy in patients aged more than 16 years.SUMMARY: Awareness of the extent of hypersomnia in children will allow physicians to effectively screen every child; once identified, further assessment should be performed in order to diagnose and treat the underlying cause" 12/01/2007 - "CONCLUSION: Several recent studies provide evidence that modafinil and sodium oxybate are effective for treatment of hypersomnia due to narcolepsy" 12/01/2007 - "Several large randomized, placebo-controlled studies indicate that modafinil and sodium oxybate are effective for treatment of hypersomnia due to narcolepsy" 01/01/2006 - "Available treatments include stimulants for hypersomnia with the quite recent widespread use of modafinil, antidepressants for cataplexy, and gamma-hydroxybutyrate for both symptoms" Order ALL the reference details at left...
6.	OxygenIBA 11/01/1986 - "Neither subjective nor objective hypersomnolence consistently improved after 1 month of oxygen administration" 10/01/1995 - "Patients who experienced one of the following symptoms: association of body mass index (-weight/height2) above 27.5 and heavy snoring, breathing stops, or daytime hypersomnolence, were selected for a nocturnal oxygen saturation recording" 07/01/1995 - "Patients with obstructive sleep apnea snore loudly and experience nocturnal oxygen desaturation and repetitive disruptions from sleep that eventually lead to daytime hypersomnolence" 02/01/1994 - "We found symptoms of excessively loud snoring, witnessed apnoeic episodes and hypersomnolence, or obstructive sleep apnoea diagnosed by overnight oxygen saturation measurements to be statistically associated with failure of nasal surgery to improve snoring." 08/01/1990 - "However, oxygen did not reduce apneas or improve daytime hypersomnolence as well as nasal CPAP in patients with mild OSA" Order ALL the reference details at left...
7.	Methylphenidate (Ritalin)FDA LinkGeneric 03/01/1978 - "An important point is emphasized in our case in which the patient reacted unfavorably to Ritalin, becoming sexually aroused, although his hypersomnia improved" 03/01/1994 - "The pharmacokinetics of (+)-methylphenidate after oral administration of 20 mg racemic methylphenidate hydrochloride and the relationship between clinical effects of plasma (+)-methylphenidate concentration were investigated in 15 patients with hypersomnia and four healthy volunteers" 03/01/1994 - "Pharmacokinetics and pharmacodynamics of (+)-threo-methylphenidate enantiomer in patients with hypersomnia." 05/01/1986 - "However, his hypersomnolence could be attributed to a central dysfunction, and during a follow-up period of 3 years, was successfully treated with methylphenidate." 09/01/1987 - "Methylphenidate, amphetamines, or other stimulant medications are used for the symptomatic treatment of the sleepiness and sleep attacks of narcolepsy and hypersomnia" Order ALL the reference details at left...
8.	Amphetamine (Amfetamine)FDA LinkGeneric 03/01/2000 - "These results indicate that modafinil is effective against somnolence and hypersomnia and does not produce a subsequent increase in sleep and suggest that the pharmacological profile of modafinil is different from that of amphetamine." 11/01/1997 - "Both rebound hypersomnolence and increased LMA intensity, which are undesirable features in wake-promoting drugs, were not observed after modafinil treatment, and thus further differentiated modafinil from amphetamine-like stimulants." 03/01/2000 - "To further characterize the awakening properties of modafinil and current psychostimulants in experimental models of hypersomnia, we examined the effect of oral administration of placebo, modafinil (5 mg kg-1) or amphetamine (1 mg kg-1) on the sleep/wake cycle and power spectral density (PSD) in cats after an 18-h water-tank sleep deprivation period" 03/01/2000 - "Effects of amphetamine and modafinil on the sleep/wake cycle during experimental hypersomnia induced by sleep deprivation in the cat." 06/01/1994 - "Psychostimulant abusers often experience anhedonia, depression, fatigue, craving, and hypersomnia and increased propensity for rapid eye movement (REM) sleep during periods of acute and subacute withdrawal from cocaine and amphetamine" Order ALL the reference details at left...
9.	Hydrocortisone (Cortisol)FDA LinkGeneric 09/01/2003 - "Cortisol circadian rhythmicity was detected during remission, but not during hypersomnia" 09/01/1988 - "Depressives with hypersomnia or increased appetite showed higher than normal 24-h urinary free cortisol concentrations" 09/01/1988 - "Comparisons were drawn to cortisol levels in patients with primary major depressive disorder who did not report hypersomnia or appetite increase (n = 23) and to normal controls (n = 23), all age- and sex-matched" 09/01/1988 - "Cortisol measures in primary major depressive disorder with hypersomnia or appetite increase." 09/01/2003 - "We report the case of a 17-year-old male subject with recurrent hypersomnia who displayed change in the 24 h expression of the hPer2 gene in whole red and white blood cells as well as markers [deep body temperature (DBT) and cortisol] of the circadian time structure during an episode of hypersomnia compared to remission" Order ALL the reference details at left...
10.	MelatoninIBA 01/01/2006 - "The role of radiotherapy on the studied parameters cannot be excluded; the findings of this case study suggest that the observed hypersomnia is not the result of melatonin deficiency alone" 01/01/2006 - "The objectives of the investigation were to assess hypersomnia, which progressively appeared in a young patient after a pinealectomy, chemotherapy, and radiotherapy for a typical germinoma, as well as the potential benefit of melatonin administration in the absence of its endogenous secretion" 09/01/2003 - "The patient was studied for the temporal characteristics of hPer2 gene, DBT, cortisol, and melatonin expression during a single 24 h span during an episode of hypersomnia and again during a single 24 h span in the following remission" 09/01/2003 - "Case study: differences in human Per2 gene expression, body temperature, cortisol, and melatonin parameters in remission and hypersomnia in a patient with recurrent hypersomnia." Order ALL the reference details at left...

Therapies and Procedures

1.	Aftercare (After-Treatment) 08/01/1986 - "In addition to the improvement in respiration during sleep, SSI decreased from a mean of 3.73 +/- 0.49 after the control night to 1.64 +/- 0.24 after treatment, reflecting an improvement in daytime hypersomnolence" 10/01/1975 - "The hypersomnia preceded the appearance of clinical signs of the muscular disease by many years and persisted even after treatment when the blood gas analysis values were greatly improved" 12/14/1998 - "The patients were rated with the Montgomery-Asberg Depression Rating Scale (MADRS) and a scale for the 'atypical' symptoms hypersomnia, hyperphagia and carbohydrate craving (the ATYP scale) before and after treatment" 04/01/1999 - "RESULTS: In comparison with the CSR group, the ISR group had a longer duration of illness, more often used antidepressants, and improved significantly less after treatment with bright light for 6 days, whereas the symptomatology in winter (Montgomery-Asberg Depression Rating Scale plus hypersomnia, hyperphagia, and carbohydrate craving) was similar in the two groups" 02/01/1994 - "We found a strong correlation between the daily use of nasal CPAP and the difference in the apnea/hypopnea index (p = 0.025; r = -0.34), the difference in mean oxygen saturation during sleep (p = 0.013; r = 0.38), and the difference in hypersomnia scores (p = 0.006; r = -0.40) obtained before and after treatment by nasal CPAP" Order ALL the reference details at left...
2.	Tracheostomy 11/28/1981 - "Treatment of hypersomnia with central stimulant drugs is often unsatisfactory, particularly in the elderly, and tracheostomy rather than medical treatment is sometimes essential in sleep apnoea." 01/01/1980 - "Therapeutic effects of tracheostomy in two cases of hypersomnia with respiratory disturbance during sleep." 02/01/1973 - "Effects of tracheostomy in two cases of hypersomnia with periodic breathing." 09/01/1972 - "Tracheostomy in hypersomnia with periodic breathing." 09/01/1984 - "Following tracheostomy, both the patient's sleep apnea and daytime hypersomnia were eliminated" Order ALL the reference details at left...
3.	Continuous Positive Airway Pressure 02/01/2005 - "Continuous positive airway pressure therapy eliminated the abnormal behaviors, unpleasant dreams, snoring and daytime hypersomnolence" 05/01/2004 - "STUDY OBJECTIVES: After nasal continuous positive airway pressure (nCPAP) treatment, several symptoms such as hypersomnolence, daytime fatigue, and impaired concentration improve in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS)" 01/01/1999 - "Therapeutic naps, medications, and supportive therapy are recommended for narcolepsy and hypersomnia; continuous positive airway pressure, weight loss, surgery, and oral devices are the common treatments for sleep apnea." 06/01/2007 - "2) Modafinil, a non amphetamine psychostimulant already marketed for idiopathic narcolepsy and hypersomnia, is the first drug to be approved in France for the treatment of patients with residual daytime drowsiness despite nasal continuous positive airway pressure treatment" Order ALL the reference details at left...
4.	Tonsillectomy 11/01/1983 - "Fourteen of the 23 patients (60.8%), 5 of the 7 who underwent tonsillectomy and 9 of the 16 treated by SMR, reported on a clinical improvement in the quality of their nocturnal sleep and diurnal hypersomnolence" 08/01/1986 - "Tonsillectomy relieves hypersomnolence." Order ALL the reference details at left...
5.	General Anesthesia 02/01/2005 - "STUDY OBJECTIVE: To determine the postoperative outcome of narcolepsy patients, a population that may be at increased risk of perioperative complications, including postoperative hypersomnia, prolonged emergence after general anesthesia, and apnea" 02/01/2005 - "Onset of torticollis was spontaneous in Case 1, after general anesthesia for cholesteatoma surgery in Case 2, after a trauma in Case 3, and during hypersomnia in Case 4. Duration of torticollis prior to diagnosis was 3 months in the first two patients and 20 days in the other two" Order ALL the reference details at left...