|3.||Hypertension (High Blood Pressure)
|4.||Renal Insufficiency (Renal Failure)
|1.||Pitt, Bertram: 15 articles (10/2015 - 04/2003)|
|2.||Solomon, Scott D: 13 articles (01/2015 - 10/2004)|
|3.||Lifton, Richard P: 13 articles (10/2014 - 01/2003)|
|4.||Kahle, Kristopher T: 10 articles (03/2009 - 01/2003)|
|5.||Sica, Domenic A: 9 articles (01/2016 - 07/2003)|
|6.||Swedberg, Karl: 9 articles (03/2015 - 10/2004)|
|7.||Zannad, Faiez: 9 articles (03/2015 - 04/2003)|
|8.||McMurray, John J V: 9 articles (09/2014 - 10/2004)|
|9.||Bakris, George L: 8 articles (10/2015 - 03/2004)|
|10.||Juurlink, David N: 8 articles (03/2015 - 04/2003)|
01/15/2015 - "Patients with hyperkalemia who received ZS-9, as compared with those who received placebo, had a significant reduction in potassium levels at 48 hours, with normokalemia maintained during 12 days of maintenance therapy. "
01/01/2016 - "Patiromer is effective in decreasing serum potassium, preventing recurrence of hyperkalemia, and reducing RAASi discontinuation. "
01/01/1987 - "In summary, alpha-adrenergic blockade ameliorates exercise-induced hyperkalemia in diabetic but not in control subjects, nonspecific beta-adrenergic blockade causes a greater increment in potassium when compared with exercise alone, and specific beta 1-adrenergic blockade exacerbates exercise-induced hyperkalemia in control, but not in diabetic subjects. "
01/01/2015 - "The efficacy of ZS9 has been shown in patients with chronic hyperkalemia, offering promise for conditions such as HF, where optimized therapy with RAASi and MRA is often limited by a concomitant, drug-induced increase in potassium. "
10/01/2014 - "Average potassium level pre resin was 5.8_0.26 in group-A and 5.8±0.6 in group-B, which reduced to 4.8±0.5 in group-A and 4.3±0.53 in group-B suggesting the efficacy of both drugs for treatment of hyperkalemia in CKD patients. "
|2.||Insulin (Novolin)FDA Link
10/01/1995 - "They have confirmed the efficacy of intravenous insulin, while raising doubts about the utility of intravenous bicarbonate, for the acute treatment of hyperkalemia. "
12/01/2015 - "We recommend monitoring up to 6 hours after insulin use in hyperkalemia."
12/01/2015 - "This was a retrospective study of hospitalized patients receiving intravenous insulin for hyperkalemia during a 6-month period. "
11/01/2014 - "Misadministration of IV Insulin Associated With Dose Measurement And Hyperkalemia Treatment."
06/01/2014 - "Insulin for the treatment of hyperkalemia: a double-edged sword?"
|3.||Glucose (Dextrose)FDA LinkGeneric
01/01/2014 - "Bolus administration of intravenous glucose in the treatment of hyperkalemia: a randomized controlled trial."
09/01/2007 - "Prolonged fasting may provoke hyperkalemia, which can be prevented by administration of intravenous dextrose."
02/01/2006 - "The mechanism in this patient appears to be hyperkalemia from the rapid administration of a concentrated glucose solution."
05/01/1993 - "This protective effect of exogenous glucose against hyperkalemia is independent of adrenergic stimulation. "
10/01/1982 - "A role for the upright posture in the development of glucose-induced hyperkalemia; prevention by a mineralocorticoid."
09/01/1997 - "The risk of hyperkalemia is avoided and the sodium/volume load can be eliminated by dialysis."
02/01/2015 - "Ingesting up to 2 boluses of PJ did not increase plasma sodium concentration or cause hyperkalemia."
06/01/2002 - "Nitrite exposure caused changes in the plasmatic electrolyte balance, which is characterised by extracellular hyperkalemia, high plasmatic chloride levels and low plasmatic sodium concentration. "
09/01/2000 - "We conclude that this abnormality in membrane Na+-K+-2Cl- cotransport could be responsible for the hyperkalemia, hyperchloremic acidemia and increased reabsorption of sodium observed in this condition and, furthermore, that such disturbance in membrane cotransport might be related to altered phospholipid concentration in cell membranes."
10/27/1996 - "The increased incidence of hyperkalemia may, in part, be secondary to decreased sodium delivery to the transplanted kidney."
|5.||Albuterol (Salbutamol)FDA LinkGeneric
07/01/1996 - "Since no side effects occurred besides a slight increase of heart rate in 3 patients, we conclude that short-term intravenous salbutamol infusion is an effective, rapid, safe and predictable way to treat children of any age suffering from acute hyperkalemia and therefore has become the first line treatment in our center."
07/01/2002 - "To evaluate the efficacy of inhaled albuterol for treatment of hyperkalemia in premature neonates by conducting a prospective, randomized placebo-controlled and double-blinded clinical trial. "
07/01/2002 - "Efficacy of albuterol inhalation in treatment of hyperkalemia in premature neonates."
06/01/1995 - "The aim of this study is to investigate the efficacy and safety of intravenous salbutamol in hyperkalemia. "
02/01/2009 - "In such situations, incorporating nebulized salbutamol with a conventional anti-hyperkalemia strategy can provide an effective therapeutic option to treat hyperkalemia, even during the anhepatic stage."
04/01/2011 - "We compared rates of hyperkalemia (>5.5 mmol/L) during equal periods of monotherapy and dual therapy and the rate of a significant rise in serum creatinine (≥0.5 mg/dL) between study periods. "
08/01/2015 - "The highest percentage of hyperkalemia was found in the DT group (10% of the patients) and of serum creatinine above UNL in the TT group (45.45%). "
02/01/2015 - "The MELD score showed a stronger predictive performance for hyperkalemia than either serum creatinine or estimated glomerular filtration rate alone. "
03/01/2014 - "At presentation, laboratory investigations revealed creatinine 12,75 mg/dl, BUN 174 mg/% and hyperkalemia 7,5 mq/L. "
11/01/2012 - "In multivariate analysis, preoperatively decreased glomerular filtration rate and increased serum creatinine as well as increased postoperative creatinine and microalbuminuria remained significant predictors of hyperkalemia. "
|7.||Spironolactone (Aldactone)FDA LinkGeneric
01/01/2016 - "The PEARL-HF study increased the proportion of patients able to titrate their spironolactone dose from 25 mg/day to 50 mg/day in patients with normokalemia who had a history of hyperkalemia or an estimated glomerular filtration rate of <60 mL/min. The OPAL-HK study allowed patients receiving patiromer to remain on their RAASi therapy. "
04/01/2015 - "Hyperkalemia risk associated with combined use of spironolactone and ACE/ARB is much stronger in real-life practice than observed in clinical trials. "
10/01/2010 - "The incidence of hyperkalemia with spironolactone treatment in these studies was similar to control groups. "
09/06/2005 - "This study was designed to determine the adequacy of monitoring patients receiving spironolactone as well as spironolactone's relationship to hyperkalemia. "
02/01/2005 - "Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study."
|8.||Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
09/01/2014 - "Several nonsteroidal mineralocorticoid receptor antagonists have demonstrated preserved cardiovascular benefit with a reduced incidence of hyperkalemia in preclinical studies. "
09/01/2015 - "The broad clinical use of steroidal mineralocorticoid receptor antagonists (MRAs) is limited by the potential risk of inducing hyperkalemia when given on top of renin-angiotensin system blockade. "
08/01/2015 - "Mineralocorticoid receptor antagonists were not affected by this warning despite increased risk of hyperkalemia. "
01/01/2015 - "The combination of the standard therapy with an ACEi or an ARB with a mineralocorticoid receptor blocker is a valid option, but has the inconvenience of frequent hyperkalemia in patients with CKD. "
11/05/2013 - "Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia."
|9.||Sodium Bicarbonate (Baking Soda)FDA LinkGeneric
08/01/2012 - "In multivariate analyses, estimated GFR<15 ml/min per 1.73 m(2) and sodium bicarbonate use were independently associated with hyperkalemia. "
07/01/1996 - "The underlying reason might be unexpected and unrecognized hyperkalemia, which was diminished by administration of sodium bicarbonate, even under the conditions of cardiocirculatory arrest."
02/01/1959 - "Severe acidosis and hyperpotassemia treated with sodium bicarbonate infusion."
10/01/1976 - "We describe a 52-year-old man who, following the discontinuation of massive intake of sodium bicarbonate, in the absence of renal insufficiency, developed progressive hyperkalemia and hyponatremia in association with hyporeninemic hypoaldosteronism. "
05/01/2011 - "Sodium bicarbonate is effective for treatment of hyperkalemia primarily by enhancing renal potassium elimination rather than by translocating potassium into cells. "
|10.||eplerenone (Inspra)FDA LinkGeneric
12/01/2015 - "Eplerenone is generally well tolerated, with the most frequent adverse event being hyperkalemia, with sexual adverse events (i.e. "
09/04/2015 - "There was no significant effect on predialysis or postdialysis BP. Eplerenone increased the risk of hyperkalemia but did not result in an excess need to permanently discontinue the drug. "
11/15/2014 - "Rates of any adverse event were significantly higher with eplerenone than placebo (odds ratio 1.37, 95% CI 1.1 to 1.71; p = 0.005), whereas the occurrence of serious adverse events and hyperkalemia was similar. "
10/22/2013 - "Underuse of eplerenone in patients with HF-REF may be due to fear of inducing hyperkalemia or WRF in high-risk patients. "
01/01/2013 - "Thus, the TI of PF-03882845 against hyperkalemia was 57-fold superior to that of eplerenone indicating that PF-03882845 may present significantly less risk for hyperkalemia compared to eplerenone. "
|1.||Renal Dialysis (Hemodialysis)
04/01/2000 - "Acute life-threatening hyperkalemia is an indication for intermittent hemodialysis because of the higher efficacy of dialysis in the clearance of low molecular weight substances."
11/01/2014 - "Our study revealed the role of LMW heparins as a potential alternative to UF heparins in the hemodialysis patients with hyperkalemia."
05/01/2010 - "This study was performed to evaluate whether any electrocardiogram (ECG) parameter can predict the presence of hyperkalemia in patients on maintenance hemodialysis (HD). "
01/01/2009 - "The aim of this study was to estimate the prevalence of hyperkalemia among Egyptian hemodialysis patients. "
01/01/1999 - "We conducted a study in known chronic hemodialysis patients who developed interdialytic hyperkalemia in spite of other treatments to control hyperkalemia. "
01/01/1979 - "Studies were performed to investigate the nature of the hyperkalemia and hypokaliuria observed in two patients after renal allotransplantation in both of whom the graft was functioning and urinary output was adequate. "
10/01/2014 - "Severe unexpected hyperkalemia (7.5- 9.4 mmol/L) was noted in our patients 12, 20, 22, and 34 days after transplant. "
10/01/2014 - "We report 4 living-donor renal recipients with hyperkalemia soon after transplant. "
08/01/2012 - "Cardiac protection with systemic hyperkalemia in reoperations with patent grafts."
01/01/2012 - "Pharmacotherapeutic agents for chronic management of hyperkalemia in kidney transplant patients may be relatively contraindicated or provide suboptimal efficacy. "
|3.||Transplantation (Transplant Recipients)
05/01/1996 - "Our study may suggest a new mechanism of coronary dysfunction after exposure to hyperkalemia and open a new area for protection of coronary endothelium in cardiac surgery and for organ preservation in transplantation surgery."
04/01/2013 - "Dabigatran-induced hyperkalemia in a renal transplant recipient: a clinical observation."
11/01/2006 - "Hyperkalemia after transplantation is a common event, occurring in up to 70% of patients. "
09/01/2000 - "Hyperkalemia is a serious electrolyte disorder and is a frequent finding in renal transplant recipients. "
10/27/1996 - "SPK recipients appear to have a greater incidence of hyperkalemia than kidney alone transplant recipients. "
|4.||Cardiopulmonary Resuscitation (CPR)
03/01/1989 - "Hyperkalemia during human cardiopulmonary resuscitation: incidence and ramifications."
01/01/1994 - "To investigate the efficacy of hemodialysis during cardiopulmonary resuscitation as an effective adjunct to the treatment of severe hyperkalemia. "
01/01/1994 - "Outcomes of severe hyperkalemia in cardiopulmonary resuscitation with concomitant hemodialysis."
10/01/2009 - "Following rapid transfusion of the last 8 units of red cell concentrate (RCC), however, cardiac arrest occurred because of hyperkalemia and did not respond to cardiopulmonary resuscitation. "
05/01/2006 - "We therefore suggest that PCPS should be considered as a therapeutic option during cardiopulmonary resuscitation for life-threatening cardiac arrest secondary to severe hyperkalemia."
05/01/2012 - "This report describes an unusual case of a patient with MMA who developed severe hyperkalemia and severe dysrhythmia during anesthesia. "
11/01/1984 - "Hyperkalemia during anesthesia."
02/01/1972 - "Hyperkalemia in anesthesia."
04/01/2015 - "The impact of exposure to liver transplantation anesthesia on the ability to treat intraoperative hyperkalemia: a simulation experience."
09/01/2014 - "Anesthesia residents need additional training in recognizing and treating operative ventricular fibrillation, especially in prone patients and rarely encountered etiologies such as hyperkalemia. "