Hyperhidrosis

Excessive sweating. In the localized type, the most frequent sites are the palms, soles, axillae, inguinal folds, and the perineal area. Its chief cause is thought to be emotional. Generalized hyperhidrosis may be induced by a hot, humid environment, by fever, or by vigorous exercise.

Also Known As:

Networked: 1969 relevant articles (363 outcomes, 303 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Sialorrhea
3.	Gustatory Sweating (Frey's Syndrome)
4.	Pruritus (Itching)
5.	Psoriasis (Pustulosis Palmaris et Plantaris)

Experts

1.	Wolosker, Nelson: 58 articles (03/2022 - 09/2003)
2.	Kauffman, Paulo: 52 articles (03/2022 - 09/2003)
3.	Puech-Leão, Pedro: 32 articles (03/2022 - 08/2005)
4.	de Campos, José Ribas Milanez: 22 articles (03/2022 - 09/2003)
5.	Glaser, Dee Anna: 21 articles (05/2020 - 11/2004)
6.	Yazbek, Guilherme: 16 articles (11/2021 - 08/2005)
7.	Kontochristopoulos, George: 14 articles (07/2022 - 06/2006)
8.	Teivelis, Marcelo Passos: 14 articles (08/2021 - 01/2014)
9.	Li, Xu: 13 articles (01/2022 - 09/2006)
10.	Pariser, David M: 12 articles (01/2021 - 05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperhidrosis:

1.	Type A Botulinum Toxins (Botox)FDA Link 08/01/2002 - "Botulinum toxin type A (BTX-A) has been shown to be highly effective in reducing palmar hyperhidrosis. " 01/01/2022 - "Botulinum toxin type A is widely used to treat primary axillary hyperhidrosis and has proven to be an effective and safe approach. " 08/01/2020 - "Administration of intra-dermal botulinum toxin type-A (Botox) has been proven to be effective in managing axillary hyperhidrosis; however, to date, no long-term data has assessed its efficacy. " 02/01/2012 - "In conclusion, we consider that low doses of botulinum toxin A is a well tolerated, safe and very effective treatment for primary frontal hyperhidrosis and it should be offered as an alternative to patients who suffer from this disorder." 10/01/2000 - "Botulinum toxin A has been shown to be a very effective treatment for focal hyperhidrosis of the axillae and palms. "
2.	Botulinum Toxins (Botulinum Toxin)IBA 01/01/2007 - "Botulinum toxin is a safe and effective treatment for idiopatic focal axillary and palmar hyperhidrosis, but very few data are reported in the literature on its effect on plantar idiopatic hyperhidrosis. " 03/01/2008 - "Few recent clinical studies have suggested that botulinum toxin is effective in the treatment of plantar hyperhidrosis. " 08/01/2009 - "Botulinum toxin injection effectively treats axillary hyperhidrosis. " 01/01/2007 - "Botulinum toxin (BTX) is an effective treatment for primary axillary hyperhidrosis. " 10/01/2002 - "Effective treatment of essential hyperhidrosis with botulinum toxin injection has been demonstrated. "
3.	oxybutynin (Tavor)FDA LinkGeneric 09/01/2014 - "Oxybutynin is effective for treating bothersome hyperhidrosis, even at atypical locations and most patients cope well with the side effects." 01/01/2008 - "Oxybutynin has been proven to be effective in patients with generalized hyperhidrosis. " 11/01/2020 - "This real life study suggests that oxybutynin is effective and safe for treatment of hyperhidrosis, both in children and adults, with mild and tolerable side effects, with significant improvement in HDSS." 05/01/2022 - "Treatment of primary palmar hyperhidrosis with oxybutynin is a good initial alternative for treatment given that it gives better results and much more improvement in QOL when compared to topical ACH. " 02/01/2018 - "There was a significant improvement in quality of life and a reduction in sweating and malodor after six weeks of treatment with topical agents and oxybutynin in patients with both hyperhidrosis and osmidrosis. "
4.	Glycopyrrolate (Glycopyrronium Bromide)FDA LinkGeneric 05/01/2022 - "Glycopyrronium cloth can be used successfully to treat palmar hyperhidrosis. " 11/01/2004 - "We conclude that glycopyrrolate iontophoresis is more effective than tap water iontophoresis in the treatment of palmoplantar hyperhidrosis and that glycopyrrolate iontophoresis has both local and systemic effects on perspiration." 01/01/2013 - "Glycopyrrolate is an effective medication in the treatment of compensatory hyperhidrosis that, can alleviate anxiety and improve patients' quality of life." 09/01/2012 - "Iontophoresis using glycopyrronium bromide is an effective and well-tolerated treatment for primary palmar hyperhidrosis. " 07/01/2002 - "We conclude that topical glycopyrrolate is effective in treating craniofacial hyperhidrosis and is associated with few adverse effects."
5.	Aluminum ChlorideIBA 12/01/2022 - "To compare the efficacy of tap water iontophoresis (TWI) versus aluminum chloride (AC) hexahydrate in the treatment of palmoplantar hyperhidrosis. " 12/01/2022 - "Comparison of the Efficacy of Tap Water Iontophoresis Versus Aluminum Chloride Hexahydrate in the Treatment of Palmoplantar Hyperhidrosis." 06/30/2023 - "Conclusion The present study provides preliminary evidence suggesting that aluminum chloride hexahydrate gel iontophoresis is an effective alternative treatment to decrease sweating rate in extended areas with fewer side effects in patients with primary palmar hyperhidrosis." 06/30/2023 - "This study investigated the effect of aluminum chloride hexahydrate gel iontophoresis compared to tap water iontophoresis on primary palmar hyperhidrosis. " 06/30/2023 - "Currently, iontophoresis with tap water and aluminum chloride hexahydrate is used for primary palmar hyperhidrosis. "
6.	incobotulinumtoxinAFDA Link 01/01/2022 - "This study aimed to evaluate the efficacy and safety of Neu-BoNT/A in subjects diagnosed with primary axillary hyperhidrosis. " 06/01/2013 - "Five trials in 82 patients supported the use of BoNT in palmar hyperhidrosis, with a Level B recommendation for BoNT-A and a Level C recommendation for BoNT-B; individual formulations received a Level U rating due to insufficient data. " 04/23/2013 - "In palmar hyperhidrosis (PH), there are 3 class II studies for A/Ona and 2 for A/Abo (individually and collectively level B for BoNT-A) and no blinded study for A/Inco (level U). " 11/14/2023 - "Medical records of patients who were referred to the outpatient department for hyperhidrosis of a tertiary care hospital and received BoNT-A for PPH from March 2003 until December 2022 were reviewed. " 05/01/2022 - "BoNT-A treatment for hyperhidrosis is not as commonly repeated as for that of cosmetic concerns."
7.	Cholinergic Antagonists (Anticholinergics)IBA 01/01/2022 - "Topical and systemic anticholinergic agents have been proven beneficial in reducing sweat production in primary axillary hyperhidrosis (PAH), although their use is limited by the increased likelihood of systemic anticholinergic drug reactions, particularly regarding systemic agents. " 09/13/2023 - "Multiple clinical trials and prospective studies support the efficacy and tolerability of oral and topical anticholinergics in the management of hyperhidrosis. " 09/13/2023 - "We review the use of topical anticholinergics in the management of focal hyperhidrosis in adults and children." 09/13/2023 - "Topical Anticholinergics in the Management of Focal Hyperhidrosis in Adults and Children: A Narrative Review." 01/01/2023 - "Nine patients (15.5%) experienced compensatory hyperhidrosis and required occasional medical management with oral anticholinergics. "
8.	SolutionsIBA 01/31/2022 - "In the treatment algorithm for patients suffering from hyperhidrosis, surgical thoracoscopic sympathicotomy offers a permanent solution, which is particularly effective in the treatment of palmar hyperhidrosis and facial blushing. " 09/01/1998 - "The use of an aqueous solution of 0.5% topical glycopyrollate was effective in the treatment of hyperhidrosis of the scalp and forehead after other treatments had proved ineffective; this appears to be the first report of its use in this condition." 12/01/2022 - "As compared to AC topical solution, TWI is an effective, safe, and inexpensive management option for palmoplantar hyperhidrosis. " 02/01/2022 - "Our work suggests that sympathetic stimulation is a potential solution for palmar hyperhidrosis." 08/01/2013 - "Severe plantar hyperhidrosis: an effective surgical solution."
9.	abobotulinumtoxinAFDA Link 11/01/2021 - "To perform a systematic review of the literature to identify evidence on the treatment approaches and outcomes associated with abobotulinumtoxinA (aboBoNT-A) treatment of hyperhidrosis. " 11/01/2021 - "Treatment approaches and outcomes associated with the use of abobotulinumtoxinA for the treatment of hyperhidrosis: A systematic review." 01/01/2015 - "Fields of anhidrotic effects of abobotulinumtoxinA in patients with compensatory hyperhidrosis." 08/01/2014 - "Comparison of intradermal injection with iontophoresis of abobotulinum toxin A for the treatment of primary axillary hyperhidrosis: a randomized, controlled trial." 08/01/2009 - "We report on a case of severe atrophy of the intrinsic muscles of the hands in a patient treated with intra-palmar BTX-A (Dysport, Speywood, UK) injections for hyperhidrosis. "
10.	AluminumIBA 11/01/2021 - "Although aluminium is used to treat hyperhidrosis, some worries have been raised about aluminium's role in breast cancer, breast cyst and Alzheimer's disease. " 09/01/2012 - "The first line treatment for primary palmar hyperhidrosis is usually topical aluminium chloride, but clinical experience indicates that it is not effective for more severe disease. " 12/01/2005 - "Efficacy of a new aluminium salt thermophobic foam in the treatment of axillary and palmar primary hyperhidrosis: a pilot exploratory trial." 02/01/2010 - "The purpose of this study was to evaluate the efficacy and tolerability of aluminium chloride gel for treatment of axillary hyperhidrosis. " 01/01/2022 - "The majority of primary care physicians (31/53; 58%) would prescribe topical aluminium chloride for palmar hyperhidrosis, whereas 28 of 53 (53%) would refer such patients to dermatology. "

Therapies and Procedures

1.	Sympathectomy (Sympathectomies) 09/28/2023 - "Although sympathectomy is highly effective for improving symptom, compensatory hyperhidrosis (CH) is a major issue. " 01/01/2023 - "Endoscopic thoracic sympathectomy (ETS) surgery is a highly effective treatment of primary hyperhidrosis (PH) for the palms, face, axillae. " 01/01/2020 - "Extended sympathectomy from R5 to R8 was shown to be quite effective in most cases, leading us to believe that this approach could be a therapeutic option for severe compensatory hyperhidrosis. " 01/01/2015 - "Although surgery is widely recognized as the best treatment for palmar hyperhidrosis (PH), the decision to perform a sympathicotomy, sympathectomy, or clipping of the thoracic sympathetic chain is based on surgeon preference. " 08/01/2014 - "Endoscopic thoracic sympathectomy has been accepted as the most effective treatment for palmar hyperhidrosis (PH). "
2.	Therapeutics 10/01/2001 - "It has proven to be effective in the treatment of hyperhidrosis and is being more frequently demanded for therapy. " 07/01/2022 - "After balancing efficacy against adverse events, systemic therapy, although off-label for all forms of hyperhidrosis, can be an added therapeutic option for patients with insufficient response to topical treatment. " 08/01/2014 - "Standard treatments for hyperhidrosis can be used with success in many patients, and newer therapies and techniques offer options that have demonstrated efficacy and safety. " 11/01/2021 - "STUDY DESIGN/MATERIALS AND METHODS: We included 15 axillary hyperhidrosis and axillary osmidrosis patients who received microwave irradiation therapy between March 2017 and March 2019. " 11/01/2016 - "Most treatment options have only been studied in patients with axillary hyperhidrosis, and more studies are needed to develop therapies for other body regions. "
3.	Injections 09/01/2021 - "There was evidence for a median reduction in the Hyperhidrosis Disease Severity Scale, a qualitative self-reported score, as well as an increasing duration of efficacy with repeated injections. " 01/01/2021 - "We included randomized controlled trials of BTX injections compared with placebo for patients with primary or secondary focal hyperhidrosis. " 10/31/2023 - "The results demonstrate that these engineered DMNPs can be an effective, painless, inexpensive alternative to hypodermic injections when treating hyperhidrosis." 01/01/2021 - "The Hyperhidrosis Disease Severity Scale (HDSS) scores of the patients at baseline and after the BTX injections were correlated with the SIT and MRF results. " 02/01/2017 - "MA, LC, and BT injections are safe and efficient minimally invasive alternatives for the treatment of axillary hyperhidrosis. "
4.	Curettage 11/01/2002 - "Subcorial curettage is an effective treatment of axillary hyperhidrosis for patients with baseline sweat rates greater than 25 mg/min." 05/01/2001 - "The purpose of this study was to compare the efficacy of subcutaneous curettage vs. injection of BT-A in axillary hyperhidrosis. " 11/01/2002 - "Gravimetrically controlled efficacy of subcorial curettage: a prospective study for treatment of axillary hyperhidrosis." 01/01/2005 - "The aim of this study was to establish the safety, efficacy, and durability of subdermal (subcorial) suction sweat gland curettage in the treatment of axillary hyperhidrosis. " 11/01/2020 - "Effectiveness of microwave treatment for hyperhidrosis and osmidrosis after curettage failure."
5.	Intradermal Injections 01/01/2001 - "Consequently, a number of clinical studies demonstrated good efficacy of intradermal injections of botulinumtoxin in patients with focal hyperhidrosis. " 09/01/2014 - "Peristomal hyperhidrosis can be controlled with BTX-A intradermal injections, improving patient pouch adherence and alleviating moisture-associated skin damage." 01/28/2013 - "Systemic toxicity concerns require BT to be administered by local injection, which in the case of hyperhidrosis means multiple painful intradermal injections by a skilled clinician at 6-monthly intervals. " 08/01/2011 - "Forty-one patients suffering from palmar hyperhidrosis, and 38 patients suffering from axillary hyperhidrosis received intradermal injections of BTX-A. " 01/01/2007 - "Ten patients with idiopathic, recalcitrant plantar hyperhidrosis were included in a pilot study and underwent intradermal injections with 100 MU of BTX-A in the plantar skin, bilaterally. "