|4.||Hypoglycemia (Reactive Hypoglycemia)
|5.||Body Weight (Weight, Body)
|1.||Umpierrez, Guillermo E: 38 articles (04/2015 - 03/2002)|
|2.||Ceriello, Antonio: 37 articles (11/2015 - 04/2002)|
|3.||Van den Berghe, Greet: 34 articles (10/2015 - 07/2002)|
|4.||Cherrington, Alan D: 29 articles (05/2015 - 02/2002)|
|5.||Cook, Curtiss B: 28 articles (01/2016 - 06/2003)|
|6.||Kowluru, Renu A: 25 articles (01/2015 - 02/2002)|
|7.||Ellard, Sian: 24 articles (07/2015 - 12/2002)|
|8.||Vanhorebeek, Ilse: 22 articles (10/2015 - 08/2005)|
|9.||Brownlee, Michael: 21 articles (09/2015 - 04/2002)|
|10.||DeFronzo, Ralph A: 20 articles (12/2015 - 11/2002)|
|1.||Insulin (Novolin)FDA Link
01/01/2011 - "Perceived efficacy of the inhaled insulin described in this study for avoiding postprandial hyperglycemia and discomfort/inconvenience were the benefits most strongly related to the evaluation of and interest in this medication."
03/01/2011 - "On the db/db background, SGLT2 deletion prevented fasting hyperglycemia, and plasma insulin levels were also dramatically improved. "
03/01/2004 - "These results also show that insulin infusion is beneficial in extremely preterm infants with transient hyperglycemia."
12/01/1988 - "Diabetic BB/OK rats, characterized by a moderate hyperglycemia and a marked decrease of pancreatic insulin content, displayed a remarkable accumulation of mononucleated cells in the endocrine pancreas. "
08/01/1978 - "Those individuals who showed the most striking improvement in tissue sensitivity to insulin actually decreased their serum insulin response to hyperglycemia; those whose improvement in tissue sensitivity was more modest showed increases in beta cell responses."
|2.||Glucose (Dextrose)FDA LinkGeneric
05/01/2011 - "Hyperleptinemia reversed hyperglycemia and hyperketonemia in diabetic C57Bl/6J mice and dramatically improved glucose tolerance. "
01/01/1987 - "Since hyperglycemia was improved when adipose tissue metabolism was unaltered, GH-dependent changes occurring in other tissues, such as liver or muscle, most likely contribute to derangements of glucose metabolism in diabetes, even when GH is not elevated. "
06/01/2006 - "There was rapid improvement in hepatic glucose effectiveness following only 3 h of NA infusion (NA3h = 31 +/- 6% suppression of EGP with hyperglycemia vs. NA- = 8 +/- 7%; P<0.01) and complete restoration of glucose effectiveness after 6 h of NA (NA6h = 41 +/- 8% suppression of EGP; P = NS vs. nondiabetic subjects). "
05/01/1992 - "We conclude that a marked decrease in whole-body, muscle, and nonoxidative glucose disposal can be induced by hyperglycemia alone."
08/01/2013 - "In-vivo silencing of miR-135a alleviated hyperglycemia, improved glucose tolerance and significantly restored the levels of IRS2 and p-Akt in the gastrocnemius skeletal muscle of db/db mice without any effect on their hepatic levels. "
|3.||Streptozocin (Streptozotocin)FDA Link
11/01/2012 - "sumatrana aqueous extract is beneficial for improvement of hyperglycemia by increasing gene expression of liver Slc2a2 and reducing expression of G6Pase and PCK1 genes in streptozotocin-induced diabetic rats."
01/01/2012 - "Further, we have investigated the therapeutic efficacy of ES cell-derived IPCs to correct hyperglycemia in syngeneic streptozotocin (STZ)-treated diabetic mice. "
09/01/1987 - "Of 22 immunomodulatory substances screened 12 were effective in modulating the course of hyperglycemia following low dose streptozotocin treatment. "
06/01/2010 - "In this study, we investigated the protective effects of fermented ginseng (FG) on hyperglycemia induced by streptozotocin (STZ) in Sprague Dawley rats. "
05/14/2014 - "Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats."
|4.||Blood Glucose (Blood Sugar)IBA
01/01/1982 - "We evaluated the conditions of three patients with marked hyperglycemia in whom hemichorea or ballism developed that resolved completely with normalization of the blood glucose level. "
07/01/2007 - "Despite the initial hyperglycemia (341+/-15 mg/dl), the blood glucose levels of DDC-STZ-treated mice were significantly improved within 6 weeks (185+/-12 mg/dl). "
08/01/2014 - "Women had better knowledge regarding types of DM, normal blood glucose values, and consequences of hyperglycemia revealed that diabetes education should be improved."
07/01/2011 - "Standard medical care with prescription of oral blood glucose lowering medication does not provide ample protection against postprandial hyperglycemia."
10/01/2004 - "We tested the hypothesis that blood glucose levels are associated with brain tissue pH (pH(b)) and that the correction of hyperglycemia would result in an improvement in pH(b). "
|5.||Metformin (Glucophage)FDA LinkGeneric
05/01/2014 - "Metformin treatment was effective in lowering hyperglycemia only during the first 2 weeks of treatment. "
11/01/2013 - "Our results suggest an in vitro mechanism that may explain the clinical evidence that metformin has vascular protective effects beyond its role in treating hyperglycemia."
10/01/2013 - "Metformin is safe and effective for therapy-induced hyperglycemia. "
03/01/2013 - "Considering data from this study, metformin is efficient to control hyperglycemia in pregnancy. "
01/27/2013 - "This is the first study to show that metformin can improve immunosuppressant-induced hyperglycemia, when administered concurrently, and reduces exocrine apoptosis (reducing the impact on potential islet progenitor cells)."
|6.||Glucagon-Like Peptide 1 (GLP 1)IBA
03/01/2011 - "After improved glycemic control, hyperglycemia during the clamps was less effective in producing oxidative stress and endothelial dysfunction and the GLP-1 administration was most effective in reducing these effects. "
01/01/2008 - "Intravenous administration of GLP-1 ameliorates hyperglycemia in patients with T2DM, but an extremely short half-life limits its utility as a therapeutic agent. "
01/01/2015 - "These findings demonstrated that TGR5 activator WB403 effectively promoted GLP-1 release, improved hyperglycemia and preserved the mass and function of pancreatic β-cells, whereas it did not show a significant side effect on gallbladder. "
06/01/2014 - "The authors sought to evaluate the efficacy of an intravenous glucagon-like peptide-1 (GLP-1) infusion, compared with placebo, to mitigate intraoperative hyperglycemia. "
06/01/2015 - "Studies are required to determine the effects of hyperglycemia on gastric emptying with the subcutaneously administered commercially available GLP-1 agonists in patients with type 2 diabetes."
|7.||Glucagon (Glukagon)FDA Link
07/01/1997 - "Glucagon secretion was less suppressed in the early part of the study in IPx, which may have contributed to the excessive hyperglycemia. "
10/01/1982 - "The aim of the present study was to determine the importance of hyperglycemia in the "downregulation" of the action of glucagon. "
10/13/1975 - "These studies indicate that excessive glucagon secretion participates in the genesis of diabetic postprandial hyperglycemia. "
11/01/2015 - "The loss of inhibition of glucagon secretion exacerbates hyperglycemia in type 1 and 2 diabetes. "
08/01/2015 - "Short-term diabetic hyperglycemia suppresses celiac ganglia neurotransmission, thereby impairing sympathetically mediated glucagon responses."
08/01/1983 - "A significant reduction in the permanent hyperglycemia caused by alloxan (50 mg/kg, iv) was observed when NIC or MNIC was given iv at a dose of 800 mg/kg 2 hr before alloxan. "
01/01/1995 - "We evaluated the protective effects of a single low-dose whole body 60Co gamma irradiation against alloxan-induced hyperglycemia in rats. "
01/01/1991 - "These interventions eliminated CPH-induced protection from alloxan, indicating a role for CPH-induced hyperglycemia in the protective effect. "
10/01/2012 - "The goal of this study was to confirm the reproducibility of caries development in chemically induced diabetic rats and investigate whether alloxan, which induces immediate and severe hyperglycemia in experimental animals, increases the lesions. "
09/01/2008 - "This study aimed to compare the effects of acute hyperglycemia in the alloxan model to normal rabbit controls on wound healing, using methods of stereology. "
06/01/2012 - "Acarbose treatment was effective in patients with uncontrolled type 2 diabetes and in patients with apparently good metabolic control owing to its positive effect on postprandial hyperglycemia (P < 0.0001). "
11/01/1996 - "Acarbose is effective in reducing postprandial hyperglycemia. "
08/01/2011 - "In addition, acarbose treatment was helpful in preventing the deposition of such fibres, as well the increase in oxidative stress induced by hyperglycemia."
04/07/2011 - " The present study showed that the beneficial effects of acarbose on arterial stiffness are mediated by an improvement of postprandial hyperglycemia and vascular remodeling markers. "
03/01/2013 - "Furthermore, all the extracts (50 mg/kg BW) showed a significant (p<0.05) effect on postprandial hyperglycemia in diabetic mice as compared with a model group, and the suppression of EP was not significantly (p>0.05) different from that of acarbose at the same dosage (50 mg/kg BW), which indicate that these fractions could be developed as potential anti-diabetic agents."
01/01/2014 - "Genetic variability in rate-limiting enzymes of pathways proposed to confer hypothetical protection against hyperglycemia might act as an important determinant of hyperglycemia toxicity in long-standing diabetes."
01/01/2006 - "In this study, we tested the hypothesis that hyperglycemia-induced increases of serum liver enzymes among its physiological concentration would be inversely associated with serum antioxidant carotenoid level. "
01/01/2003 - "The present study was aimed at addressing the effect of hyperglycemia on antioxidant enzymes. "
10/01/2014 - "Termination of hyperglycemia failed to reverse decrease in MMR enzymes and increase in D-loop sequence variants. "
01/01/2014 - "One of the therapeutic approaches in treating diabetes is to reduce postprandial hyperglycemia by inhibiting major carbohydrate hydrolyzing enzymes. "
|1.||Transplantation (Transplant Recipients)
02/01/2014 - "Hyperglycemia of the diabetic rats was improved and the destruction of pancreatic cells was partly repaired by HUMSC transplantation. "
02/01/2014 - "We transplanted HUMSCs into diabetic rats to investigate whether these cells can colonize in vivo and differentiate into pancreatic β-cells, and whether the hyperglycemia of diabetic rats can be improved by transplantation. "
04/01/2015 - "The aim of this study was to determine the effects of intraoperative hyperglycemia on postoperative outcomes in orthotopic liver transplant recipients. "
07/01/2014 - "Hyperglycemia during the 1st month after transplantation occurred in 34.5% of recipients, and the occurrence of PTDM to the end of study was 19.9%. "
09/01/2012 - "Experimental transplantation studies have shown that these cells are capable of reducing hyperglycemia in short-term assays. "
11/24/2000 - "In db/db mice, oral administration of compound 2 elicited significant correction of hyperglycemia. "
09/21/2000 - "It activated IRTK with an EC(50) of 300 nM and did not induce the activation of closely related receptors (IGFIR, EGFR, and PDGFR) at concentrations up to 30 000 nM. Oral administration of the compound to hyperglycemic db/db mice (0.1-10 mg/kg/day) elicited substantial to nearly complete correction of hyperglycemia in a dose-dependent manner. "
01/01/1999 - "A dose-dependent reduction of hyperglycemia (10%, 15%, 28%, and 66%) was found in db/db mice after the fifth oral administration of 3, 10, 30, and 100 mg/kg/d. "
04/15/1984 - "A single oral administration of TPTOH produced marked hyperglycemia and triglyceridemia in rabbits and hamsters, but no evidence of diabetes was found in mice, rats and guinea-pigs. "
09/01/1981 - "The mechanisms of hyperglycemia induced by an oral administration of As2O3 were investigated in treated and non-treated rats. "
01/01/1995 - "Immunofluorescence for GLUT2 was dramatically reduced in the beta-cells of grafts with 200 islets exposed to hyperglycemia. "
01/01/2005 - "Graft of microencapsulated SC+ neonatal porcine islets versus encapsulated islets alone resulted in significantly longer remission of hyperglycemia in NOD mice. "
01/01/1990 - "In contrast, function of intrasplenic islets was more durable with delayed onset of hyperglycemia observed in only two of six grafts at 13 and 18 months. "
06/18/1999 - "The efficacy of pancreatic islet transplants in correcting hyperglycemia and slowing the progression of complications in diabetics has been confirmed by many experimental and clinical studies. "
02/01/2011 - "Removal of graft-bearing intestinal segments led to recurrence of hyperglycemia indicating that transplanted islets were responsible for improved outcomes. "
|4.||Drug Therapy (Chemotherapy)
01/01/2005 - "Nevertheless, continued improvement in DES delivery as well as optimal adjunctive pharmacotherapy and control of hyperglycemia will be required to achieve the best clinical outcomes following PCI with DES in patients with diabetes."
04/01/2015 - "Inhibition of PGC-1α or control of hyperglycemia may be beneficial in improving the efficacy of chemotherapy in MM patients with diabetes. "
08/01/2002 - "The time point at which medication should be added to improved health care and management changes is not currently known, but loss of body condition and development of hyperglycemia suggest more advanced PPID that would likely benefit from drug therapy. "
03/01/1987 - "Tumour pH under induced hyperglycemia and efficacy of chemotherapy."
10/01/2015 - "In view of ethnic differences in the propensity for diabetes, this study aims to delineate the characteristics of pediatric patients at risk for hyperglycemia during chemotherapy in Taiwan. "
03/01/1993 - "Protection against hyperglycemia was already achieved with a total of 3 injections of 5-T-G, 1 injection each given before the first 3 of 5 LD-STZ injections. "
01/01/2015 - "After multiple injections of low-dose STZ, most male C57BL/6J inbred mice got hyperglycemia, and then underwent syn-BMT. "
05/01/2014 - "This article provides an overview of the development of insulins, oral agents, and noninsulin injectable agents used in the management of hyperglycemia in patients with diabetes. "
02/01/2011 - "Single injections of T3 (7 ng·g⁻¹ i.p.) rapidly and markedly attenuated hyperglycemia. "
01/01/2011 - "Mild hyperglycemia (250-450 mg/dL) was seen after 28 days following three injections of STZ. "