|1.||Hypertension (High Blood Pressure)
|1.||Stowasser, Michael: 37 articles (01/2016 - 02/2002)|
|2.||Rossi, Gian Paolo: 37 articles (12/2015 - 07/2002)|
|3.||Mulatero, Paolo: 32 articles (01/2016 - 07/2002)|
|4.||Reincke, Martin: 31 articles (01/2016 - 12/2003)|
|5.||Gordon, Richard D: 31 articles (01/2016 - 02/2002)|
|6.||Sasano, Hironobu: 31 articles (10/2015 - 03/2002)|
|7.||Veglio, Franco: 28 articles (08/2015 - 07/2002)|
|8.||Weber, Karl T: 27 articles (12/2013 - 08/2003)|
|9.||Wu, Vin-Cent: 26 articles (11/2015 - 08/2009)|
|10.||Mantero, Franco: 26 articles (01/2015 - 05/2003)|
09/01/2012 - "The obligatory use of tests confirming autonomy of aldosterone secretion in patients screened for primary aldosteronism seems cost-effective in limiting the number of patients for further diagnosis."
07/01/2001 - "If all hypertensive patients are screened for primary aldosteronism and the workup is continued methodically in those with a positive screening test, patients with unilateral overproduction of aldosterone who potentially can be cured surgically are not denied the possibility of cure."
08/01/2010 - "Adrenal venous sampling (AVS) is generally considered to be the gold standard in distinguishing unilateral and bilateral aldosterone hypersecretion in primary hyperaldosteronism. "
01/01/2008 - "Adrenal vein sampling (AVS) is considered the gold-standard test to demonstrate unilateral aldosterone excess in primary aldosteronism, yet no single approach to interpretation of AVS has been externally validated. "
08/01/2014 - "The aim of the study was to assess the repeatability and interpretation of urinary aldosterone in patients examined for suspected primary aldosteronism. "
|2.||Spironolactone (Aldactone)FDA LinkGeneric
12/01/2002 - "Of the 14 subjects with confirmed hyperaldosteronism who have been treated with spironolactone, all have manifested a significant reduction in blood pressure. "
04/01/2012 - "Unilateral primary aldosteronism with spontaneous remission after long-term spironolactone therapy."
04/01/2012 - "Spontaneous remission of idiopathic aldosteronism after long-term treatment with spironolactone: results from the German Conn's Registry."
11/01/1984 - "The volume studies were repeated in 6 of the primary aldosteronism patients during treatment with spironolactone for over 3 months. "
04/01/2015 - "In the long term, spironolactone therapy in patients with primary aldosteronism had significant effect on regression of IMT, which was comparable to surgical treatment in patients with unilateral forms of primary aldosteronism."
07/01/2000 - "The blood chemistry studies showed elevated levels of peripheral renin with evidence of secondary aldosteronism. "
08/01/1989 - "In the present study, the renal, hemodynamic, humoral, and vascular effects of a synthetic (WY-47663) human analogue were studied in five water-loaded (15 ml H2O/kg) patients with adenomatous primary aldosteronism, a salt-sensitive, low renin, volume-expanded syndrome. "
01/17/1989 - "The results of a peripheral renin-study were typical for secondary aldosteronism. "
09/28/1968 - "[Renin studies in idiopathic edemas with secondary hyperaldosteronism]."
01/01/1968 - "Studies on plasma renin activity in patients with primary aldosteronism."
|4.||eplerenone (Inspra)FDA LinkGeneric
02/01/2012 - "Eplerenone use in primary aldosteronism during pregnancy."
05/01/2009 - "Clinical studies support the concept that eplerenone is effective for the treatment of salt-sensitive hypertension as well as idiopathic hyperaldosteronism and does not have adverse anti-androgenic adverse effects. "
08/01/2011 - "Spironolactone is more effective than eplerenone at lowering blood pressure in patients with primary aldosteronism."
03/01/2008 - "The aim of this prospective, randomised, open-label, blinded-end point study was to compare the efficacy and safety of eplerenone versus spironolactone in patients with bilateral idiopathic hyperaldosteronism (IHA). "
01/01/2013 - "Effectiveness of eplerenone or spironolactone treatment in preserving renal function in primary aldosteronism."
03/01/2015 - "A small number of studies have compared the effects of surgery and mineralocorticoid antagonists either on BP, on serum potassium levels, or on the incidence of cardiovascular and renal outcomes in patients with primary aldosteronism with or without an APA; these studies found no difference between the two therapeutic options. "
10/01/2006 - "It is known that there is a large variance in ARR value between races and ARR is affected by many factors, such as drugs, posture and serum potassium etc. The objective of this study is to establish the threshold of ARR for screening primary aldosteronism in Chinese hypertensive patients. "
01/01/2015 - "The results showed that LogARR values were significantly higher (P < 0.001), and PRA and serum potassium values were significantly lower (P < 0.001) in primary aldosteronism patients. "
12/01/2013 - "Patient 3, now 3 years/3 months old, still shows hyperreninemic hyperaldosteronism requiring potassium supplementation. "
05/01/2013 - "Endocrine and hypertensive disorders of potassium regulation: primary aldosteronism."
02/01/1987 - "Both short and prolonged aldosteronism produced similar increases in the transport pool and in the transcellular sodium flux, but the transepithelial electrical potential difference (p.d.) was significantly greater in rats given the prolonged infusion. "
07/23/1981 - "A diet containing 150 mmol of sodium was given to the patients with spontaneous aldosteronism, and one containing 10 mmol of sodium was given to the normal subjects, for three days before treatment and throughout the study. "
07/01/2014 - "Hyperaldosteronism causes sodium and fluid retention in the kidney. "
03/01/2014 - "In the presence of a high sodium intake primary aldosteronism carries has detrimental effects on the cardiovascular system, which translate into an excess rate of cardiovascular events. "
04/01/2013 - "Urinary sodium level was an independent predictor of severity of OSA only in patients with hyperaldosteronism. "
|7.||Dexamethasone (Maxidex)FDA LinkGeneric
08/01/1989 - "We reviewed the pathophysiology of our previously reported female patient who had glucocorticoid-responsive hyperaldosteronism and was treated successfully with daily dose of dexamethasone (Dex) for 21 years. "
09/01/2001 - "In primary aldosteronism, we evaluated usefulness of plasma 18-OHF determination and the dexamethasone suppression test in the diagnosis of glucocorticoid-remediable aldosteronism using the genetic test as the gold standard. "
09/01/2004 - "[Adrenal cortex scintigraphy with and without dexamethasone suppression in the study of primary aldosteronism]."
08/20/1982 - "[A study on the mechanism of abnormal steroid secretions in a case of dexamethasone suppressible hyperaldosteronism]."
01/01/2008 - "[131I] norcholesterol (NP-59) scintigraphy with dexamethasone suppression for subclassification and lateralization of primary aldosteronism was evaluated in 49 patients with long-term follow-up after diagnosis and treatment. "
|8.||Amiloride (Midamor)FDA LinkGeneric
10/01/2007 - "Conn's syndrome in pregnancy successfully treated with amiloride."
03/01/2001 - "We found that hyperaldosteronism was associated with significantly higher alveolar fluid clearance and that this increase was related to the amiloride-sensitive component. "
01/01/1982 - "The effect of amiloride was studied prospectively in 12 patients with primary hyperaldosteronism. "
01/01/1982 - "Amiloride in primary hyperaldosteronism."
01/01/1978 - "1. Amiloride (40 mg/day) was given to nineteen patients with primary hyperaldosteronism. "
12/01/1989 - "Laboratory evaluation showed hyperaldosteronism and hyporeninemia despite enalapril administration. "
04/01/1989 - "Thus, low-dose enalapril resulted in a significant improvement of the NYHA functional class in patients with severe chronic heart failure, accompanied by an improvement in left ventricular function and a decrease in secondary aldosteronism."
07/01/1983 - "The study reported here prospectively evaluated the prevention of diuretic-induced secondary hyperaldosteronism and hypokalemia by a converting enzyme inhibitor, enalapril (MK 421). "
01/01/1983 - "Therefore, we undertook a study to evaluate the prevention of diuretic-induced hypokalemia and secondary hyperaldosteronism using a new converting enzyme inhibitor, MK-421. "
01/01/1983 - "Although MK-421 did not prevent diuretic-induced hypokalemia or hyperaldosteronism in the first week, after that time hypokalemia was reversed and ASR returned to normal. "
|10.||Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
12/01/2015 - "Mineralocorticoid Receptor Antagonists and Clinical Outcomes in Primary Aldosteronism: As Good as Surgery?"
01/01/2015 - "An effective treatment is available for patients with primary aldosteronism, with mineralocorticoid receptor antagonists in bilateral, and minimal invasive adrenal surgery in unilateral disease, which emphasizes the importance of early detection, adequate diagnostic work-up and treatment. "
01/01/2015 - "Progress in primary aldosteronism: mineralocorticoid receptor antagonists and management of primary aldosteronism in pregnancy."
10/01/2014 - "Administrative data on diagnosis and mineralocorticoid receptor antagonist prescription identified patients with primary aldosteronism in Taiwan."
02/01/2014 - "We have now investigated the effects of salt status and blockade of mineralocorticoid receptors (MRs) on cardiac pathophysiology in uninephrectomized Sprague-Dawley rats implanted with an osmotic minipump to maintain hyperaldosteronism. "
10/01/2000 - "Laparoscopic adrenalectomy is superior to an open approach to treat primary hyperaldosteronism."
09/01/2007 - "In appropriately selected patients with primary hyperaldosteronism, laparoscopic adrenalectomy is effective in improving long-term BP control. "
01/01/2003 - "Although some complications can occur, mostly at the beginning of the learning curve, laparoscopic transperitoneal adrenalectomy is effective treatment for primary hyperaldosteronism."
04/01/2006 - "Laparoscopic adrenalectomy is a safe and effective way to treat primary hyperaldosteronism. "
03/01/2002 - "Laparoscopic adrenalectomy is safe and effective for the treatment of primary hyperaldosteronism with minimal associated morbidity and a short hospital stay. "
08/01/1986 - "Is single oral administration of captopril beneficial in screening for primary aldosteronism?"
01/01/1987 - "Single oral administration of captopril may not bring an improvement in screening of primary aldosteronism."
04/01/1978 - "To determine the effect of aldosterone antagonist on renal prostaglandin E synthesis, the rate of urinary excretion of immunoreactive prostaglandin E was measured radioimmunologically before and during the oral administration of an aldosterone antagonist, spironolactone, in 5 patients with essential hypertension, 3 with primary aldosteronism and 2 with postoperative primary aldosteronism. "
09/20/1983 - "A 58-year-old man with primary aldosteronism associated with chronic chronic renal failure was treated with CAPD, oral administrations of Trilostane and furosemide. "
01/01/1987 - "Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were measured in 19 cases with primary aldosteronism (PA) and 72 with essential hypertension (EHT) to differentiate the two disorders in the following conditions: after overnight recumbency (basal state) and after oral administration of captopril. "
|3.||Drug Therapy (Chemotherapy)
08/01/2003 - "The majority of patients with primary aldosteronism have the IHA subtype and require pharmacotherapy. "
10/01/1988 - "The electrocardiograms (ECGs) of a series of 34 patients with primary hyperaldosteronism (PHA), 17 treated surgically (group I) nine treated medically (group II) and eight treated with/by both surgery and drug therapy (group III) were analysed to determine whether the treatment of PHA resulted in an improvement in the ECG changes of left ventricular hypertrophy (LVH) and also whether there was a difference in this improvement between medically and surgically treated patients. "
08/01/2003 - "Diagnosis of primary aldosteronism results in either the surgical cure of hypertension or targeted pharmacotherapy. "
01/01/1965 - "[Effect of hypotensive drug therapy on hyperaldosteronism associated with malignant hypertension]."
10/04/1997 - "In the 13 patients with Conn's syndrome, the same hemodynamic parameters were studied in 13 after drug therapy using spironolactone and in 8 after surgery. "
03/01/2012 - "Predictive factors of left ventricular mass changes after treatment of primary aldosteronism."
12/01/2010 - "Cardiovascular and renal damage in primary aldosteronism: outcomes after treatment."
04/01/2009 - "Management of primary aldosteronism: its complications and their outcomes after treatment."
04/01/2009 - "Intrarenal hemodynamics in primary aldosteronism before and after treatment."
01/14/2008 - "Cardiovascular outcomes in patients with primary aldosteronism after treatment."
|5.||Sodium-Restricted Diet (Diet, Sodium Restricted)
12/01/1976 - "1. Mild secondary hyperaldosteronism was induced in ten healthy young males by a low sodium diet for 14 days. "
05/01/2004 - "In a previous study, cardiac fibrosis could not be induced in an experimental model of hyperaldosteronism with a low-salt diet. "
07/01/1992 - "Low sodium diet in hyperaldosteronism prevented hypertension and left ventricular hypertrophy, but not scarring. "
09/01/2012 - "We tested this in 2 animal models of aldosteronism (aldosterone infusion or low-sodium diet) and in patients with primary aldosteronism. "
01/01/1979 - "Hyperaldosteronism in the sodium depleted rat: effect of a low sodium diet or diuretic treatment on steroid output by the superfused adrenal zona glomerulosa."