Hymecromone

A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.

Also Known As:

4-Methylumbelliferone; 7-Hydroxy-4-methyl-coumarin; Cholestil; Mendiaxon; 4 Methylumbelliferone; 7 Hydroxy 4 methyl coumarin; Imecromone; Methylumbelliferone; Resocyanine; 2H-1-Benzopyran-2-one, 7-hydroxy-4-methyl-

Networked: 123 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Umbelliferones: 3
        Hymecromone: 123
        4-methylumbelliferylguanidinobenzoate: 14
        4-methylumbelliferyl glucoside: 7
        4-methylumbelliferyl glucuronide: 5
        4-methylumbelliferyl iduronide: 4
        bis(4-methylumbelliferyl)pyrophosphate: 4
        4-methylumbelliferyl oleate: 3
        4-methylumbelliferyl phosphate: 3
        4-methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-beta-glucopyranoside: 3
        4-trifluoromethylumbelliferyl iduronide: 2
        6,8-difluoro-4-methylumbelliferyl phosphate: 2
        2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid: 1
        3-glucuronosyl-1-4-(xylosyl-1-)-4-methylumbelliferone sulfate: 1
        4-methylumbelliferyl caprylate: 1
        4-methylumbelliferyl heptanoate: 1
        4-methylumbelliferyl sulfate: 1
        4-methylumbelliferyl-N-acetylchitotetraoside: 1
        methylumbelliferyl-alpha-D-mannopyranoside: 1
        methylumbelliferyl-beta-D-xyloside: 1
        2'-(4-methylumbelliferyl)-N-acetylneuraminic acid-alpha2,3-galactose
        3-chloro-4-methylumbelliferone
        4-dinitrobenzenesulfonate 4-methylumbelliferyl-2
        4-methyllumbelliferyl stearate
        4-methylumbelliferone 8-carbaldehyde
        4-Methylumbelliferone-3,5-dihydroxybenzyl
        4-methylumbelliferone-3-acetic acid
        4-methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside
        4-methylumbelliferyl alpha-mannobioside
        4-methylumbelliferyl beta-D-ribopyranoside
        4-methylumbelliferyl butyrate
        4-methylumbelliferyl glycosides
        4-methylumbelliferyl lactoside
        4-methylumbelliferyl palmitate
        4-methylumbelliferyl phenylphosphonate
        4-methylumbelliferyl thymidine 3'-phosphate
        4-methylumbelliferyl thymidine 5'-phosphate
        4-methylumbelliferyl-2-deoxy-2-acetamido-6-O-sulfoglucosamine
        4-methylumbelliferyl-3-O-cellobiosyl-glucopyranoside
        4-methylumbelliferyl-4-trimethylammonium cinnamate
        4-methylumbelliferyl-beta-D-cellotrioside
        4-methylumbelliferyl-beta-D-mannopyranoside
        4-methylumbelliferyl-beta-glucosaminide
        4-methylumbelliferyl-casein
        4-methylumbelliferyl-galactopyranoside
        4-methylumbelliferyl-galactoside 6-sulfate
        4-methylumbelliferyl-galactosyl(1-3)-N-acetylgalactosaminide
        4-methylumbelliferyl-N,N-diacetylchitobioside
        4-methylumbelliferyl-N-acetyl-chitotrioside
        4-methylumbelliferyl-N-acetylamino-beta-galactoside
        4-methylumbelliferyl-rutinoside
        4-methylumbelliferylarabinoside
        4-methylumbelliferyliduronate 2-sulfate
        4-methylumbelliferylmaltoside
        4-trifluoromethylumbelliferyl-N-acetylneuraminic acid glycoside
        4-trifluoromethylumbelliferylgalactopyranoside
        4-trifluoromethylumbelliferylglucuronide
        6,8-difluoro-4-methylumbelliferyl sulfate
        6-hexadecanoylamino-4-methylumbelliferyl-galactopyranoside
        7-(chlorocarbonylmethoxy)-4-methylcoumarin
        7-hydroxy-3-methylcoumarin
        benzyloxycarbonylphenylalanine 4-methylcoumaryl-7-ester
        bis-(4-methylumbelliferyl)phosphate
        glucuronyl-(1-4)-xylopyranosyl-1-(4-methylumbelliferone)
        methylumbelliferyl 2-acetamido-2-deoxy-beta-D-lactoside
        methylumbelliferyl N-acetyl-4-deoxy-4-fluoro-beta-D-glucosaminide
        sialyl-2-3-galactosyl-1-4-xylosyl-1-(4-methylumbelliferone)
        sulfate-O-3-xylosyl-(4-methylumbelliferone)
        tert-butyloxycarbonyl-1-alanine 4-methylumbelliferyl ester
        xylosyl-1-4-xylosyl-1-(4-methylumbelliferone)
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Umbelliferones: 3
        Hymecromone: 123
        4-methylumbelliferylguanidinobenzoate: 14
        4-methylumbelliferyl glucoside: 7
        4-methylumbelliferyl glucuronide: 5
        4-methylumbelliferyl iduronide: 4
        bis(4-methylumbelliferyl)pyrophosphate: 4
        4-methylumbelliferyl oleate: 3
        4-methylumbelliferyl phosphate: 3
        4-methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-beta-glucopyranoside: 3
        4-trifluoromethylumbelliferyl iduronide: 2
        6,8-difluoro-4-methylumbelliferyl phosphate: 2
        2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid: 1
        3-glucuronosyl-1-4-(xylosyl-1-)-4-methylumbelliferone sulfate: 1
        4-methylumbelliferyl caprylate: 1
        4-methylumbelliferyl heptanoate: 1
        4-methylumbelliferyl sulfate: 1
        4-methylumbelliferyl-N-acetylchitotetraoside: 1
        methylumbelliferyl-alpha-D-mannopyranoside: 1
        methylumbelliferyl-beta-D-xyloside: 1
        2'-(4-methylumbelliferyl)-N-acetylneuraminic acid-alpha2,3-galactose
        3-chloro-4-methylumbelliferone
        4-dinitrobenzenesulfonate 4-methylumbelliferyl-2
        4-methyllumbelliferyl stearate
        4-methylumbelliferone 8-carbaldehyde
        4-Methylumbelliferone-3,5-dihydroxybenzyl
        4-methylumbelliferone-3-acetic acid
        4-methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside
        4-methylumbelliferyl alpha-mannobioside
        4-methylumbelliferyl beta-D-ribopyranoside
        4-methylumbelliferyl butyrate
        4-methylumbelliferyl glycosides
        4-methylumbelliferyl lactoside
        4-methylumbelliferyl palmitate
        4-methylumbelliferyl phenylphosphonate
        4-methylumbelliferyl thymidine 3'-phosphate
        4-methylumbelliferyl thymidine 5'-phosphate
        4-methylumbelliferyl-2-deoxy-2-acetamido-6-O-sulfoglucosamine
        4-methylumbelliferyl-3-O-cellobiosyl-glucopyranoside
        4-methylumbelliferyl-4-trimethylammonium cinnamate
        4-methylumbelliferyl-beta-D-cellotrioside
        4-methylumbelliferyl-beta-D-mannopyranoside
        4-methylumbelliferyl-beta-glucosaminide
        4-methylumbelliferyl-casein
        4-methylumbelliferyl-galactopyranoside
        4-methylumbelliferyl-galactoside 6-sulfate
        4-methylumbelliferyl-galactosyl(1-3)-N-acetylgalactosaminide
        4-methylumbelliferyl-N,N-diacetylchitobioside
        4-methylumbelliferyl-N-acetyl-chitotrioside
        4-methylumbelliferyl-N-acetylamino-beta-galactoside
        4-methylumbelliferyl-rutinoside
        4-methylumbelliferylarabinoside
        4-methylumbelliferyliduronate 2-sulfate
        4-methylumbelliferylmaltoside
        4-trifluoromethylumbelliferyl-N-acetylneuraminic acid glycoside
        4-trifluoromethylumbelliferylgalactopyranoside
        4-trifluoromethylumbelliferylglucuronide
        6,8-difluoro-4-methylumbelliferyl sulfate
        6-hexadecanoylamino-4-methylumbelliferyl-galactopyranoside
        7-(chlorocarbonylmethoxy)-4-methylcoumarin
        7-hydroxy-3-methylcoumarin
        benzyloxycarbonylphenylalanine 4-methylcoumaryl-7-ester
        bis-(4-methylumbelliferyl)phosphate
        glucuronyl-(1-4)-xylopyranosyl-1-(4-methylumbelliferone)
        methylumbelliferyl 2-acetamido-2-deoxy-beta-D-lactoside
        methylumbelliferyl N-acetyl-4-deoxy-4-fluoro-beta-D-glucosaminide
        sialyl-2-3-galactosyl-1-4-xylosyl-1-(4-methylumbelliferone)
        sulfate-O-3-xylosyl-(4-methylumbelliferone)
        tert-butyloxycarbonyl-1-alanine 4-methylumbelliferyl ester
        xylosyl-1-4-xylosyl-1-(4-methylumbelliferone)

Experts

1.	Ishiguro, Naoki: 6 articles (01/2020 - 01/2012)
2.	Kudo, Daisuke: 6 articles (01/2019 - 09/2004)
3.	Kakizaki, Ikuko: 6 articles (01/2017 - 09/2004)
4.	Bollyky, Paul L: 5 articles (01/2022 - 01/2015)
5.	Malvicini, Mariana: 5 articles (01/2022 - 03/2012)
6.	Mazzolini, Guillermo: 5 articles (01/2022 - 03/2012)
7.	Nishida, Yoshihiro: 5 articles (01/2018 - 01/2012)
8.	Yoshihara, Shuichi: 5 articles (09/2007 - 09/2004)
9.	Nagy, Nadine: 4 articles (01/2022 - 01/2015)
10.	Díaz, Mariángeles: 4 articles (12/2021 - 01/2017)

Related Diseases

1.	Pain (Aches) 01/01/2022 - "After silencing CD44 expression or delivering 4-methylumbelliferone (4-MU), the pain severity and prostatic inflammation were significantly relieved. " 01/01/2001 - "Control of dyspepsia and pain symptoms of biliary origin was more marked and constant with hymecromone than with placebo. " 11/01/1996 - "An abnormal emptying pattern of the gallbladder was identified in patients with acalculous biliary colic, and hymecromone was partly effective to reduce pain, despite a minor effect on gallbladder emptying pattern." 01/01/1986 - "The results showed that tiropramide was significantly more effective in decreasing the number of attacks of pain and in improving pain and dyspepsia symptoms than imecromone. "
2.	Neoplasms (Cancer) 11/01/2021 - "In this study, tumor subtypes were constructed based on phenotype (treatment with 4-methylumbelliferone) or genotype (knockdown of ROCK1) modifications and then aspirated through a constriction-channel based impedance flow cytometry to characterize single-cell Cspecific membrane and σcytoplasm . " 10/01/2016 - "In a previous study, the present authors reported for the first time that 4-methylumbelliferone (MU) inhibited HA synthesis and suppressed tumor growth. " 01/01/2021 - "Targeting the Tumor Extracellular Matrix by the Natural Molecule 4-Methylumbelliferone: A Complementary and Alternative Cancer Therapeutic Strategy." 09/01/2017 - "In the recent years, 4-methylumbelliferone (4-MU) has been gaining importance, both as an anti-cancer agent and as a dietary supplement. " 01/26/2016 - "Changes in cell motility were examined in 8 PDAC cell lines in response to inhibition of HA production by treatment with 4-methylumbelliferone (4-MU) and to promotion by treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or by co-culture with tumor-derived stromal fibroblasts. "
3.	Lung Diseases (Lung Disease) 01/01/2022 - "Additionally, higher baseline sputum HA levels were associated with a greater decrease in sputum HA.CONCLUSIONAfter 4 days of exposure to oral hymecromone, healthy human subjects experienced a significant reduction in sputum HA levels, indicating this oral therapy may have potential in pulmonary diseases where HA is implicated in pathogenesis.TRIAL REGISTRATIONClinicalTrials.gov NCT02780752.FUNDINGStanford Medicine Catalyst, Stanford SPARK, Stanford Innovative Medicines Accelerator program, NIH training grants 5T32AI052073-14 and T32HL129970."
4.	Renal Cell Carcinoma (Grawitz Tumor) 07/01/2013 - "To our knowledge this is the first study to show that the combination of sorafenib and the nontoxic dietary supplement hymecromone is highly effective for controlling renal cell carcinoma." 07/01/2013 - "In the current study we examined the antitumor properties of hymecromone, sorafenib and the combination in renal cell carcinoma models. " 07/01/2013 - "Hymecromone plus sorafenib synergistically inhibited proliferation (greater than 95%), motility/invasion (65%) and capillary formation (76%) in renal cell carcinoma and/or endothelial cells, and induced apoptosis eightfold (p <0.001). " 07/01/2013 - "Using proliferation, clonogenic and apoptosis assays, we examined the effects of hymecromone (0 to 32 μg/ml), sorafenib (0 to 3.2 μg/ml) and hymecromone plus sorafenib in Caki-1, 786-O, ACHN and A498 renal cell carcinoma cells, and HMVEC-L and HUVEC endothelial cells. " 07/01/2013 - "Dietary supplement hymecromone and sorafenib: a novel combination for the control of renal cell carcinoma."
5.	Inflammation (Inflammations) 02/27/2022 - "The plant-derived molecule 4-methylumbelliferone (4-MU) has beneficial effects in animal models of inflammation and autoimmunity diseases. " 02/27/2022 - "Plant-Derived Molecule 4-Methylumbelliferone Suppresses FcεRI-Mediated Mast Cell Activation and Allergic Inflammation." 01/01/2022 - "After silencing CD44 expression or delivering 4-methylumbelliferone (4-MU), the pain severity and prostatic inflammation were significantly relieved. " 01/28/2022 - "Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone Suppresses the Secretory Processes That Ensure the Invasion of Neutrophils into Tissues and Induce Inflammation." 03/01/2017 - "Effects of 4-methylumbelliferone and high molecular weight hyaluronic acid on the inflammation of corneal stromal cells induced by LPS."

Related Drugs and Biologics

1.	Hyaluronic Acid (Hyaluronan)
2.	Sorafenib (BAY 43-9006)
3.	tiropramide
4.	Choline (Choline Chloride)
5.	Amino Acids
6.	Hymecromone
7.	Hyaluronan Synthases
8.	Proteins (Proteins, Gene)
9.	Hyaluronoglucosaminidase (Hyaluronidase)
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Glycemic Control
4.	X-Ray Therapy
5.	Immunotherapy