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Normal Pressure Hydrocephalus

A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see GAIT DISORDERS, NEUROLOGIC), progressive intellectual decline, and URINARY INCONTINENCE. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of CSF including SUBARACHNOID HEMORRHAGE, chronic MENINGITIS, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)
Also Known As:
Hydrocephalus, Normal Pressure; Hakim's Syndrome; Hydrocephalus, Normal-Pressure; NPH (Normal Pressure Hydrocephalus); Hakim Syndromes; Hakim's Syndromes; Hakims Syndrome; NPHs (Normal Pressure Hydrocephalus); Syndrome, Hakim; Syndrome, Hakim's; Syndromes, Hakim; Syndromes, Hakim's; Hakim Syndrome
Networked: 668 relevant articles (33 outcomes, 84 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Dementia (Dementias)
2. Alzheimer Disease (Alzheimer's Disease)
3. Cognitive Dysfunction
4. Cerebrospinal Fluid Leak
5. Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)

Experts

1. Leinonen, Ville: 21 articles (02/2022 - 01/2011)
2. Zetterberg, Henrik: 17 articles (02/2022 - 04/2013)
3. Miyajima, Masakazu: 17 articles (08/2021 - 02/2007)
4. Nakajima, Madoka: 15 articles (03/2022 - 09/2009)
5. Hiltunen, Mikko: 14 articles (02/2022 - 11/2012)
6. Arai, Hajime: 14 articles (08/2021 - 02/2007)
7. Rigamonti, Daniele: 13 articles (07/2019 - 09/2004)
8. Blennow, Kaj: 12 articles (02/2022 - 04/2013)
9. Rauramaa, Tuomas: 12 articles (02/2022 - 01/2014)
10. Jääskeläinen, Juha E: 12 articles (03/2021 - 01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Normal Pressure Hydrocephalus:
1. Biomarkers (Surrogate Marker)IBA
2. gadobutrolIBA
3. Amyloid (Amyloid Fibrils)IBA
4. Amyloid beta-PeptidesIBA
5. Peptides (Polypeptides)IBA
05/13/2011 - "Nine subjects had idiopathic normal pressure hydrocephalus (iNPH), and the other 22 chronic hydrocephalus from other origins (oCH).The Aβ42 peptide concentration was measured by an ELISA test in 31 ventricular CSF samples and in 5 lumbar CSF samples from patients with communicating hydrocephalus. "
12/18/2002 - "Reverse-phase high pressure liquid chromatography (HPLC) fractions of a human with normal pressure hydrocephalus cerebrospinal fluid (CSF), co-migrating with NPFF-related synthetic peptides, were characterized by capillary HPLC coupled on-line to nanospray ion trap tandem mass spectrometry. "
01/01/2023 - "This study aims to study the association between pancreatic islet amyloid polypeptide (IAPP) and Alzheimer's disease neuropathological change (ADNC) in brain biopsies obtained from subjects with idiopathic normal pressure hydrocephalus (iNPH) and in post-mortem (PM) brain samples obtained from aged individuals. "
01/01/2021 - "Forty-two acute TBI patients and 37 idiopathic normal pressure hydrocephalus (iNPH) patients were included in the analysis of tryptic brevican and neurocan peptides in CSF using parallel reaction monitoring mass spectrometry. "
01/01/2015 - "Lumbar CSF from 32 patients with idiopathic normal pressure hydrocephalus (iNPH) (samples were obtained before and 1 year after shunting), 15 patients with AD, and 12 normal controls was analyzed for AD-related proteins and APLP1-derived Aβ-like peptides (APL1β) (a surrogate marker for Aβ). "
6. tau Proteins (tau Protein)IBA
7. boldenone undecylenate (Equipoise)IBA
8. Acetazolamide (Diamox)FDA LinkGeneric
9. Levofloxacin (Levaquin)FDA Link
10. NeurotoxinsIBA

Therapies and Procedures

1. Ventriculoperitoneal Shunt
2. Therapeutics
3. Ventriculostomy
4. Cerebrospinal Fluid Shunts
5. Activities of Daily Living (ADL)