Hydralazine (Apresoline)

A direct-acting vasodilator that is used as an antihypertensive agent.

Also Known As:

Apresoline; Hydrazinophthalazine; Apressin; Apressoline; Hydralazine Hydrochloride; Hydralazine mono-Hydrochloride; Nepresol; Hydralazine mono Hydrochloride; Hydrochloride, Hydralazine; mono-Hydrochloride, Hydralazine; Hydrallazin; 1(2H)-Phthalazinone, hydrazone

Networked: 1993 relevant articles (160 outcomes, 246 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Taylor, Anne L: 14 articles (12/2014 - 06/2002)
2.	Worcel, Manuel: 14 articles (12/2014 - 06/2002)
3.	Cohn, Jay N: 12 articles (12/2014 - 06/2002)
4.	Yancy, Clyde W: 11 articles (01/2018 - 06/2002)
5.	Tam, S William: 11 articles (12/2014 - 12/2005)
6.	Taja-Chayeb, Lucia: 10 articles (10/2014 - 05/2003)
7.	Sabolinski, Michael L: 10 articles (08/2012 - 12/2005)
8.	Shi, Riyi: 9 articles (01/2022 - 07/2006)
9.	Candelaria, Myrna: 9 articles (11/2017 - 01/2006)
10.	Trejo-Becerril, Catalina: 8 articles (01/2018 - 05/2003)

Related Diseases

1.	Heart Failure 08/01/1978 - "It has been shown that hydralazine is beneficial in chronic heart failure by virtue of its afterload reducing effect. " 07/01/2014 - "Consequently, in the African-American Heart Failure Trial (A-HeFT) in self-identified black patients with symptomatic HF, adding a fixed-dose combination ISDN-hydralazine to modern guideline-based care improved outcomes versus placebo, including all-cause mortality, and led to early trial termination. " 11/01/1985 - "The clearance of the single intravenous dose of hydralazine averaged 29.5 +/- 8.0 ml/min/kg, which is not different than that reported in populations without heart failure. " 06/01/1985 - "Hydralazine in the management of chronic congestive heart failure." 01/01/1984 - "Improved cardiac performance during exercise following hydralazine treatment in chronic heart failure."
2.	Hypertension (High Blood Pressure) 12/01/1983 - "N, and especially B + N, provided an efficacious once-daily treatment for systemic hypertension, and addition of hydralazine was effective in most nonresponders." 12/01/2023 - "The objective of this study was to investigate the potential effects of hydralazine (Hyd, a hypertension treatment drug) on the development process of AD and its mechanisms. " 04/04/1953 - "[Hydrazinophthalazine in hypertension; clinical studies]." 02/01/2023 - "Hydralazine is a commonly prescribed medication which is used in the treatment of hypertension. " 12/01/2022 - "However, hydralazine was more efficacious, produced adequate control of BP in a higher number of patients, and had a lower incidence of persistent hypertension."
3.	Fibrosis (Cirrhosis) 08/15/2023 - "In the in vivo part, hydralazine preserved renal function in AKI mice and improved the AKI-to-CKD transition by decreasing renal glomerulosclerosis and fibrosis independently of blood pressure lowering. " 01/01/2021 - "Obese offspring of hydralazine-treated lean mothers displayed reduced markers of renal fibrosis and oxidative stress. " 01/01/2021 - "In rodent models, low-dose hydralazine has previously been shown to reduce renal fibrosis via DNA demethylation. " 01/01/2021 - "Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet." 01/01/2017 - "Hydralazine-induced CpG promoter demethylation subsequently attenuated renal fibrosis and preserved excretory renal function independent of its blood pressure-lowering effects. "
4.	Neoplasms (Cancer) 06/15/1994 - "Meanwhile, the therapeutic efficacy of hydralazine and heat was correlated with the changes in tumor blood flow, first of all with the delayed effects. " 01/01/1992 - "These data confirm that hydralazine at doses effective at reducing tumor blood flow also impairs renal function, and is therefore likely to affect the pharmacokinetics of any co-administered drug that is cleared by the kidney." 06/15/1994 - "This study was aimed to assess the dependence on tumor size and blood flow of the efficacy of a vasoactive drug hydralazine with thermoradiotherapy. " 10/01/1989 - "In addition to cessation of perfusion in individual vessels, hydralazine eliminated flow in large patches of vasculature distributed non-uniformly throughout the tumor. " 04/19/2016 - "Even though hydralazine is already tested in clinical cancer trials, its mechanism of antitumor action remains undefined. "
5.	Hypertensive Crisis 07/01/1982 - "Until further studies are conducted, hydralazine will continue to be the treatment of choice for hypertensive emergencies of pregnancy." 09/01/2002 - "The data suggest that hydralazine bolus dose is equally safe and more effective than continuous drip in the management of hypertensive emergencies in pregnancy." 09/01/2002 - "Management of hypertensive emergencies of pregnancy by hydralazine bolus injection vs continuous drip--a comparative study." 02/01/2001 - "A hypertensive crisis developed during surgery but was resolved within minutes after administration of hydralazine. " 05/01/1991 - "[Use of intravenous hydralazine in treatment of hypertensive crisis]."

Related Drugs and Biologics

1.	Isosorbide Dinitrate (Isordil)
2.	Vasodilator Agents (Vasodilators)
3.	Nitrates
4.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
5.	Nifedipine (Adalat)
6.	Enalapril
7.	Captopril (Capoten)
8.	Antihypertensive Agents (Antihypertensives)
9.	Labetalol (Normodyne)
10.	Methyldopa (Aldomet)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Intraperitoneal Injections
5.	Carotid Endarterectomy