Hycanthone

06/01/1977 - "A controlled trial of hycanthone and placebo in schistosomiasis mansoni in St. Lucia."
01/01/1974 - "Clinical trials of hycanthone in schistosomiasis mansoni in St. Lucia."
09/01/1972 - "Hycanthone trial in the treatment of Schistosoma mansoni infection in Sudan."
02/18/1978 - "Hycanthone dose-response in Schistosoma mansoni infection in Kenya."
01/01/1978 - "[Treatment of schistosomiasis mansoni with hycanthone (our experience in 3,500 cases)]."

09/01/1978 - "haematobium infections before and 6 weeks after successful treatment with hycanthone; 52 local individuals were studied as controls. "
09/01/1977 - "Genetically transferred resistance to the antischistosomal drug hycanthone has been observed in several strains of Schistosoma mansoni: 1) in the progeny of worms to whose hosts hycanthone had been administered 54 to 70 days after exposure to cercariae (Type I); 2) in the progeny of worms to whose hosts hycanthone had been administered when the worms were still in an immature stage (27 to 29 days after percutaneous cercarial exposure) (Type II); and 3) in the progeny of worms from hosts that had been infected with cercariae of one sex followed by infection with the opposite sex 2 to 58 weeks later (Type III). "
01/01/1974 - "[Effect of hycanthone at different evolutive stages of experimental infection of the mouse by Schistosoma mansoni]."
11/01/1970 - "Etrenol (hycanthone) in the treatment of Schistosoma haematobium infections in Iraq."
03/01/1977 - "This finding suggests that differences in the reversibility of hycanthone may correlate with the usefulness of the drug in the therapy of schistosome infections by different species of parasites. "

01/01/1976 - "Hycanthone in experimental schistosomiasis studies on liver pathology in mice treated with one and two doses."
11/01/1975 - "Considering that an important aspect of the control of schistosomiasis is mass treatment, further studies regarding mutagenicity, teratogenicity, resistance, and toxicological effects of hycanthone are still required before this drug can be recommended for wide use."
09/01/1972 - "Preliminary trial of the effect of hycanthone (Etrenol) in the mass treatment of urinary bilharziasis."
10/31/1970 - "Clinical trials of hycanthone (etrenol) in urinary tract bilharziasis."
07/01/1970 - "Clinical trials of Hycanthone in the treatment of bilharziasis."

08/01/1985 - "All persons with 300 or more eggs g-1 faeces were then treated with a single dose of hycanthone, 1.5 mg kg-1 body-weight. "
01/01/1982 - "Hycanthone at a dose of 2.5 mg kg body weight was given in 1973 and 1974 to persons found by a sedimentation concentration technique to be excreting Schistosoma mansoni eggs. "
09/01/1977 - "Most of these, 677, were given a single injection of hycanthone (2.5 mg/kg of body weight), and the same treatment was administered to 159 patients the second year. "
07/01/1978 - "Hycanthone was given as a single intramuscular injection at a dose of 3.0 mg per kilogramme body weight. "
07/01/1976 - "Clinical trials of hycanthone (single intramuscular dose) were undertaken in schistosomiasis mansoni patients in St. Lucia at five dose levels: 3.0, 2.5, 2.0, 1.5, and 1.0 mg/kg body weight. "

05/01/1991 - "Our results in vitro and in vivo indicate that hycanthone and chlorophenoxamine might be appropriate tools for the circumvention of MDR in human tumors."
05/01/1991 - "Reversing multidrug resistance in L1210 tumor cells by hycanthone or chlorophenoxamine in vitro and in vivo."
08/01/1980 - "Hycanthone is an antischistosomal drug with promising antitumor activity against experimental animal tumors. "
01/15/1979 - "Non-infected control mice developed 0.8% of these tumors compared to 10.2% in mice treated with hycanthone. "
08/01/1978 - "Hycanthone was given to 15 patients with metastatic cancer in order to determine the maximum tolerable dose. "