Huntington Disease (Huntington's Disease)

A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
Also Known As:
Huntington's Disease; Huntington's Chorea; Progressive Chorea, Chronic Hereditary (Huntington); Chorea, Huntington; Chorea, Huntington's; Akinetic-Rigid Variant of Huntington Disease; Chorea, Chronic Progressive Hereditary (Huntington); Chronic Progressive Hereditary Chorea (Huntington); Huntington Chronic Progressive Hereditary Chorea; Huntington Disease, Akinetic-Rigid Variant; Huntington Disease, Juvenile; Huntington Disease, Juvenile-Onset; Huntington Disease, Late Onset; Juvenile-Onset Huntington Disease; Late-Onset Huntington Disease; Progressive Chorea, Hereditary, Chronic (Huntington); Akinetic Rigid Variant of Huntington Disease; Huntington Disease, Akinetic Rigid Variant; Huntington Disease, Juvenile Onset; Huntington Disease, Late-Onset; Juvenile Onset Huntington Disease; Late Onset Huntington Disease; Huntington Chorea; Juvenile Huntington Disease
Networked: 5093 relevant articles (171 outcomes, 507 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Alzheimer Disease (Alzheimer's Disease)
3. Neurodegenerative Diseases (Neurodegenerative Disease)
4. Stroke (Strokes)
5. Chorea (Rheumatic Chorea)


1. Hayden, Michael R: 72 articles (12/2015 - 02/2002)
2. Rubinsztein, David C: 52 articles (05/2015 - 05/2002)
3. Cattaneo, Elena: 48 articles (01/2015 - 10/2002)
4. Ross, Christopher A: 47 articles (06/2015 - 05/2002)
5. Bates, Gillian P: 45 articles (05/2015 - 05/2002)
6. Li, Xiao-Jiang: 45 articles (03/2015 - 03/2002)
7. Ferrante, Robert J: 41 articles (06/2014 - 01/2002)
8. Beal, M Flint: 38 articles (09/2014 - 01/2002)
9. Nukina, Nobuyuki: 36 articles (02/2015 - 04/2003)
10. Leavitt, Blair R: 33 articles (05/2015 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Huntington Disease:
1. polyglutamineIBA
2. Quinolinic AcidIBA
3. Minocycline (Cyclops)FDA LinkGeneric
4. 3-nitropropionic acidIBA
5. Proteins (Proteins, Gene)IBA
6. N-Methylaspartate (NMDA)IBA
7. Genetic Markers (Genetic Marker)IBA
8. Brain-Derived Neurotrophic Factor (BDNF)IBA
9. ethyl eicosapentaenoic acidIBA
10. MelatoninIBA

Therapies and Procedures

1. Transplantation (Transplant Recipients)
2. Transplants (Transplant)
3. Aftercare (After-Treatment)
4. Tissue Therapy (Cell Therapy)
5. Therapeutics