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Bisbenzimidazole (Hoechst 33258)

A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.
Also Known As:
Hoechst 33258; 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol, trihydrochloride; Bisbenzimidazole Trihydrochloride; Hoe-33258; NSC-322921; Pibenzimol; Hoe 33258; Hoe33258; NSC 322921; NSC322921; Bisbenzimide; 4-(5-(5-(4-Methylpiperazin-1-yl)benzimidazol-2- yl)benzimidazol-2-yl)phenol
Networked: 145 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Zyner, Elzbieta: 3 articles (01/2010 - 03/2004)
2. Ochocki, Justyn: 3 articles (01/2010 - 03/2004)
3. Kosmider, Beata: 3 articles (01/2010 - 03/2004)
4. Osiecka, Regina: 3 articles (01/2010 - 03/2004)
5. Liu, Xue-Zhong: 2 articles (04/2014 - 06/2013)
6. Fu, Ying-Xiao: 2 articles (04/2014 - 06/2013)
7. Yuan, Yan: 2 articles (04/2014 - 06/2013)
8. Liu, Zong-Ping: 2 articles (04/2014 - 06/2013)
9. Bian, Jian-Chun: 2 articles (04/2014 - 06/2013)
10. Gu, Jian-Hong: 2 articles (04/2014 - 06/2013)

Related Diseases

1. Necrosis
2. Infection
09/12/2001 - "We describe a method of rapidly detecting and assessing the intensity of 'Candidatus Xenohaliotis californiensis' infections in abalone gastrointestinal tissue using the nucleic acid-specific fluorochrome Hoechst 33258. "
02/01/1991 - "The use of this image cytometer is discussed for: (1) the measurement of the DNA ploidy distribution of isolated mature rat liver nuclei labeled with 4',6-diamidine-2-phenylindole; (2) the comparison of the DNA ploidy distributions of the same samples measured by image cytometry (ICM) and flow cytometry (FCM); and (3) the quantification of chlamydial infection by double labeling cells with antichlamydiae antibody and Hoechst 33258 for nuclear DNA analysis. "
11/01/2013 - "In this study, the viability of J774 macrophages phagocytosing Pa IID1117 (elastase- and protease-positive) was significantly reduced (53.8±4.5%) 48 h after infection and cell death occurred via apoptosis as seen by Hoechst 33258 staining and terminal deoxynucleotidyl transferase-mediated d-UTP nick end labeling (TUNEL) assay. "
03/01/2011 - "To observe the inhibitive effect of Baicalin against influenza A H1N1 virus infection in epithelial cell line A549, the cell proliferation and cytotoxicity were assayed by MTT, the cell cycle and the apoptosis were analyzed by flowcytometer using PI staining, the morphology of cellular nucleolus was observed by Hoechst 33258 staining and the effects of activation on caspase 3 and caspase 8/9 were also detected by immunofluorescent staining with a fluorescence microscope. "
10/01/2002 - "In the present studies we compared a number of colorimetric (crystal violet, MTT [3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide], and neutral red) and fluorometric (Alamar Blue, bisbenzimide [Hoechst 33258], fluorescein diacetate, and rhodamine 6G) methods to visual scoring of antiviral activity in influenza A virus infections in Madin Darby canine kidney (MDCK) cells. "
3. Carcinoma (Carcinomatosis)
4. Pancreatic Neoplasms (Pancreatic Cancer)
5. Tetraploidy

Related Drugs and Biologics

1. Propidium (Propidium Iodide)
2. Bisbenzimidazole (Hoechst 33258)
3. Annexin A5
4. Fluorescent Dyes (Fluorescent Probes)
5. DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)
6. Fluorescein-5-isothiocyanate (FITC)
7. Carbon Monoxide
8. Sepharose (Agarose)
9. 5,5',6,6'- tetrachloro- 1,1',3,3'- tetraethylbenzimidazolocarbocyanine
10. rhodamine 6G

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Heterologous Transplantation (Xenotransplantation)