HLA-DP Antigens (HLA-DP)

A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.

Also Known As:

Networked: 300 relevant articles (9 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fontenot, Andrew P: 8 articles (06/2014 - 04/2005)
2.	Amicosante, Massimo: 7 articles (09/2009 - 03/2004)
3.	Falkenburg, J H Frederik: 6 articles (01/2022 - 01/2013)
4.	Wang, Lanlan: 6 articles (07/2018 - 01/2014)
5.	Saltini, C: 6 articles (05/2004 - 03/2001)
6.	Cai, Bei: 5 articles (07/2018 - 01/2014)
7.	Yang, Bin: 5 articles (07/2018 - 12/2014)
8.	Liao, Yun: 5 articles (01/2018 - 01/2014)
9.	Falta, Michael T: 5 articles (06/2014 - 11/2005)
10.	Amicosante, M: 5 articles (05/2004 - 07/2001)

Related Diseases

1.	Infections 08/01/2012 - "Both A alleles of HLA-DP SNP rs3077 and rs9277535 showed strong protective effects for spontaneous HBV clearance from persistent HBV infection in the Han Chinese population." 01/01/2012 - "These results suggest that the associations between the HLA-DP locus and the protective effects against persistent HBV infection and with clearance of HBV were replicated widely in East Asian populations; however, there are no reports of GWAS in Caucasian or African populations. " 01/01/2016 - "Our study suggests that HLA-DP/DQ polymorphisms can affect susceptibility and resistance to HBV infection in Chinese populations, and are possibly linked to race and sex." 01/01/2013 - "We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. " 09/01/2022 - "The aim was to evaluate the role of HLA-DP/DQ single-nucleotide polymorphisms (SNPs) in Helicobacter pylori infection in Kafrelsheikh governorate, Egypt. "
2.	Chronic Hepatitis B 01/01/2012 - "Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean." 12/01/2014 - "[Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection]." 01/01/2014 - "Previous studies showed that single nucleotide polymorphisms (SNPs) in the HLA-DP, TCF19 and EHMT2 genes may affect the chronic hepatitis B (CHB). " 01/01/2017 - "Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population." 12/01/2015 - "[Genetic factors in HLA-DP associated with pathology, therapeutic outcome, and prognosis of chronic hepatitis B]."
3.	Virus Diseases (Viral Diseases) 08/01/2012 - "Relationship between HLA-DP gene polymorphisms and clearance of chronic hepatitis B virus infections: case-control study and meta-analysis." 01/08/2015 - "These effects might reflect modulation of autoimmunity or indirect effects of HLA class I and HLA-DP alleles on response to viral infections such as that of influenza. " 11/01/2013 - "HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations." 09/12/2013 - "HLA class II upregulation during viral infection leads to HLA-DP-directed graft-versus-host disease after CD4+ donor lymphocyte infusion."
4.	Fibrosis (Cirrhosis) 11/01/2013 - "In conclusion, HLA-DP polymorphisms affect genotype B HBV clearance, regulate immune selection of viral mutations, and influence cirrhosis and HCC risks contributed by HBV mutations. " 11/01/2013 - "The interactions of C1653T, T1674C/G, and G1896A mutations with HLA-DP polymorphisms promoting HBV clearance significantly decreased cirrhosis risk. " 11/01/2013 - "Significant effects of viral mutations on cirrhosis and HCC were selectively evident in those with HLA-DP polymorphisms promoting HBV persistence. " 10/01/2014 - "To investigate the genetic association between cirrhosis and polymorphisms in the genes encoding major histocompatibility complex, class II (HLA)-DR beta 1 (DRB1) and HLA-DP beta 1 (DPB1). " 03/01/1999 - "HLA-DR-DQ alleles and HLA-DP alleles are independently associated with susceptibility to different stages of post-schistosomal hepatic fibrosis in the Chinese population."
5.	Persistent Infection 05/01/2012 - "In addition, HLA-DP rs3077 showed an approaching significant effect on susceptibility to HBV persistent infection and HCC development when considering multiple testing adjustments. " 05/01/2009 - "Our findings show that genetic variants in the HLA-DP locus are strongly associated with risk of persistent infection with hepatitis B virus." 10/01/2017 - "Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population." 04/01/2011 - "We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. "

Related Drugs and Biologics

1.	HLA-DQ Antigens (HLA-DQ)
2.	HLA-DR Antigens (HLA-DR)
3.	Antigens
4.	Histocompatibility Antigens Class II
5.	HLA-C Antigens (HLA-C)
6.	Antibodies
7.	Hepatitis B Surface Antigens (HBsAg)
8.	Antiviral Agents (Antivirals)
9.	HLA Antigens (Human Leukocyte Antigens)
10.	HLA-D Antigens

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation
3.	Transplantation
4.	Stem Cell Transplantation
5.	Hematopoietic Stem Cell Transplantation