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Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell)

A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.
Also Known As:
Histiocytosis, Langerhans Cell; Histiocytosis-X; Letterer-Siwe Disease; Langerhans-Cell Granulomatosis; Histiocytosis, Langerhans-Cell; Hand-Schueller-Christian Disease; Hand-Schueller-Christian Syndrome; Hand-Schüller-Christian Disease; Hand-Schüller-Christian Syndrome; Hashimoto-Pritzger Disease; Histiocytosis, Generalized; Langerhans Cell Granulomatosis; Langerhans Cell Granulomatosis, Pulmonary; Langerhans Cell Histiocytosis; Non-Lipid Reticuloendotheliosis; Pulmonary Histiocytosis X; Pulmonary Langerhans Cell Granulomatosis; Schueller-Christian Disease; Systemic Aleukemic Reticuloendotheliosis; Type 2 Histiocytosis; Aleukemic Reticuloendothelioses, Systemic; Aleukemic Reticuloendotheliosis, Systemic; Cell Granulomatoses, Langerhans; Cell Granulomatosis, Langerhans; Cell Histiocytoses, Langerhans; Cell Histiocytosis, Langerhans; Disease, Hand-Schueller-Christian; Disease, Hand-Schüller-Christian; Disease, Hashimoto-Pritzger; Disease, Letterer-Siwe; Disease, Schueller-Christian; Diseases, Hashimoto-Pritzger; Generalized Histiocytoses; Generalized Histiocytosis; Granulomatoses, Langerhans Cell; Granulomatosis, Langerhans Cell; Granulomatosis, Langerhans-Cell; Hand Schueller Christian Disease; Hand Schueller Christian Syndrome; Hand Schüller Christian Disease; Hand Schüller Christian Syndrome; Hashimoto Pritzger Disease; Hashimoto-Pritzger Diseases; Histiocytoses, Generalized; Histiocytoses, Langerhans Cell; Histiocytoses, Type 2; Histiocytosis X, Pulmonary; Histiocytosis, Type 2; Langerhans Cell Granulomatoses; Langerhans Cell Histiocytoses; Letterer Siwe Disease; Non Lipid Reticuloendotheliosis; Non-Lipid Reticuloendothelioses; Reticuloendothelioses, Non-Lipid; Reticuloendothelioses, Systemic Aleukemic; Reticuloendotheliosis, Non-Lipid; Reticuloendotheliosis, Systemic Aleukemic; Schueller Christian Disease; Syndrome, Hand-Schueller-Christian; Syndrome, Hand-Schüller-Christian; Systemic Aleukemic Reticuloendothelioses; Type 2 Histiocytoses; Histiocytosis X
Networked: 1343 relevant articles (76 outcomes, 102 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Erdheim-Chester Disease
2. Juvenile Xanthogranuloma
3. Neoplasms (Cancer)
4. Sarcoidosis (Schaumann Disease)
5. Pulmonary Fibrosis (Fibrosing Alveolitis)

Experts

1. Morimoto, Akira: 24 articles (01/2022 - 08/2003)
2. Imashuku, Shinsaku: 24 articles (01/2021 - 08/2003)
3. McClain, Kenneth L: 20 articles (10/2021 - 12/2003)
4. Donadieu, Jean: 19 articles (01/2021 - 02/2004)
5. Imamura, Toshihiko: 16 articles (01/2021 - 07/2004)
6. Allen, Carl E: 15 articles (10/2021 - 09/2007)
7. Henter, Jan-Inge: 14 articles (01/2022 - 07/2003)
8. Shioda, Yoko: 13 articles (01/2022 - 01/2011)
9. Haroche, Julien: 13 articles (10/2021 - 12/2011)
10. Minkov, Milen: 11 articles (01/2022 - 12/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Langerhans-Cell Histiocytosis:
1. CladribineFDA LinkGeneric
2. Cytarabine (Cytosar-U)FDA LinkGeneric
3. VemurafenibIBA
4. Etoposide (VP 16)FDA LinkGeneric
5. Thalidomide (Thalomid)FDA Link
6. Adrenal Cortex Hormones (Corticosteroids)IBA
7. Lenalidomide (CC 5013)FDA Link
8. S100 Proteins (S 100 Protein)IBA
9. Vinblastine (Vinblastine Sulfate)FDA Link
10. Radioisotopes (Radionuclides)IBA

Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Radiotherapy
4. Hematopoietic Stem Cell Transplantation
5. Salvage Therapy