|2.||Pulmonary Hypertension (Ayerza Syndrome)
|4.||Myelodysplastic Syndromes (Myelodysplastic Syndrome)
|5.||Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell)
|1.||Imashuku, Shinsaku: 14 articles (12/2015 - 08/2003)|
|2.||Morimoto, Akira: 13 articles (02/2015 - 08/2003)|
|3.||McClain, Kenneth L: 11 articles (01/2015 - 12/2003)|
|4.||Imamura, Toshihiko: 7 articles (01/2015 - 07/2004)|
|5.||Egeler, R Maarten: 6 articles (10/2015 - 01/2008)|
|6.||Henter, Jan-Inge: 6 articles (07/2011 - 07/2003)|
|7.||Tazi, A: 5 articles (10/2015 - 07/2004)|
|8.||Donadieu, Jean: 5 articles (09/2015 - 02/2004)|
|9.||Kudo, Kazuko: 5 articles (12/2014 - 08/2006)|
|10.||Gadner, H: 5 articles (01/2007 - 07/2000)|
06/01/2012 - "Cladribine is a highly effective medication used in treating Langerhans cell histiocytosis. "
02/01/2008 - "Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smoker."
04/01/2001 - "Langerhans cell histiocytosis: central nervous system involvement treated successfully with 2-chlorodeoxyadenosine."
11/01/2012 - "Cladribine is effective against cystic pulmonary Langerhans cell histiocytosis."
06/01/2012 - "The effectiveness of cladribine in the childhood form of Langerhans cell histiocytosis is investigated only in 1 multicentric clinical study, other data are taken from single case reports or small series studies. "
|2.||Thalidomide (Thalomid)FDA Link
03/01/1998 - "We report one case of Langerhans cell histiocytosis in a 33-year-old woman with resistant vulvar involvement whose cutaneous lesions improved with thalidomide. "
01/01/1995 - "Adult cutaneous Langerhans cell histiocytosis: remission with thalidomide treatment."
09/01/1993 - "Remission of Langerhans cell histiocytosis with thalidomide treatment."
01/01/2007 - "A phase II trial using thalidomide for Langerhans cell histiocytosis."
08/01/2006 - "The purpose of this study was to test the disease-controlling effect of thalidomide in a case of adult multisystem Langerhans cell histiocytosis with cutaneomucous and hypothalamic localizations at dermatology department, of Mohammed-V military hospital, Rabat. "
|3.||Vinblastine (Vinblastine Sulfate)FDA Link
01/01/2011 - "Efficacy of vinblastine in central nervous system Langerhans cell histiocytosis: a nationwide retrospective study."
01/01/2011 - "Vinblastine (VBL) is the standard treatment for systemic Langerhans cell histiocytosis (LCH), but little is known about its efficacy in central nervous system (CNS) mass lesions. "
01/01/2010 - "Vinblastine, the reference treatment for multisystem forms of Langerhans-cell histiocytosis, is not indicated for pulmonary involvement in adults. "
05/01/1991 - "Disseminated cerebral histiocytosis X responding to vinblastine therapy: a case report."
02/01/1984 - "The ultrastructural investigations, carried out before and after vinblastine, showed the presence in some histiocytosis X cells (HXC) of coated Birbeck granules (BG). "
|4.||Mechlorethamine (Nitrogen Mustard)FDA Link
04/01/1979 - "Two infants suffering from histiocytosis X were treated successfully with a topically applied nitrogen mustard. "
08/01/1991 - "We conclude that the topical application of nitrogen mustard is an effective treatment for cutaneous Langerhans cell histiocytosis. "
08/01/1991 - "Topical nitrogen mustard: an effective treatment for cutaneous Langerhans cell histiocytosis."
03/01/2012 - "Topical nitrogen mustard therapy in patients with Langerhans cell histiocytosis."
01/01/2003 - "Topical nitrogen mustard ointment with occlusion for Langerhans' cell histiocytosis of the scalp."
|5.||Cytarabine (Cytosar-U)FDA LinkGeneric
01/01/2013 - "Disseminated Langerhans cell histiocytosis associated with acute myeloid leukaemia: complete remission with daunorubicin and cytarabine."
01/01/2009 - "The combination of 2-chlorodeoxyadenosine (2-CDA) and cytosine arabinoside (Ara-C) has been shown to be effective in children with refractory Langerhans cell histiocytosis (LCH). "
09/17/2015 - "An international phase 2 study combining cladribine and cytarabine (Ara-C) was initiated for patients with refractory, risk-organ-positive Langerhans cell histiocytosis (LCH) in 2005. "
09/17/2015 - "Cladribine and cytarabine in refractory multisystem Langerhans cell histiocytosis: results of an international phase 2 study."
11/01/2005 - "The aim of this study was to assess the efficacy and adverse effects of 2-chlorodeoxyadenosine (2-CdA) and cytosine arabinoside (Ara-C) in children with refractory Langerhans cell histiocytosis (LCH) and haematopoietic dysfunction. "
09/01/2006 - "The objective of this study was to evaluate the efficacy of 2-chlorodeoxyadenosine (2-CdA), a purine nucleoside analog, in treating recurrent Langerhans cell histiocytosis (LCH) in children. "
03/01/2003 - "To evaluate the efficacy of 2-chlorodeoxyadenosine (2-CDA), a purine nucleoside analogue, in treating disseminated Langerhans cell histiocytosis (LCH). "
10/01/2015 - "Cladribine, a purine analogue, chemotherapy may dramatically improve lung function in patients with progressive pulmonary Langerhans cell histiocytosis, but this treatment should be used only in the setting of clinical research. "
|7.||Prednisolone (Predate)FDA LinkGeneric
12/01/2004 - "Langerhans cell histiocytosis involving the skin of an elderly woman: a satisfactory remission with oral prednisolone alone."
11/20/1977 - "[Our experience with prolonged prednisolone therapy of Hand-Schüller-Christian disease]."
01/01/1977 - "An account is presented of the experience acquired in the prolonged prednisolone treatment, at 2-day intervals, of 6 patients with Hand-Schüller-Christian disease. "
01/01/1977 - "Experience of prolonged treatment of hand-Schüller-Christian disease with prednisolone."
07/01/1977 - "Efficiency of cranial irradiation and prednisolone toward Hand-Schüller-Christian disease: report of a case."
|8.||lenalidomide (CC 5013)FDA Link
11/01/2012 - "We observed an excellent effect of lenalidomide in multifocal aggressive, repeatedly relapsing Langerhans cell histiocytosis where it led to complete remission. "
03/01/2012 - "Lenalidomide proved effective in multisystem Langerhans cell histiocytosis."
11/01/2012 - "We showed an effect of lenalidomide in Langerhans cell histiocytosis and in Castleman disease. "
01/01/2012 - "[Lenalidomide induced therapeutic response in a patient with aggressive multi-system Langerhans cell histiocytosis resistant to 2-chloro-deoxyadenosine and early relapsing after high-dose BEAM chemotherapy with autologous peripheral blood stem cell transplantation]."
11/01/2012 - "[The effect of lenalidomide on rare blood disorders: Langerhans cell histiocytosis, multicentric Castleman disease, POEMS syndrome, Erdheim-Chester disease and angiomatosis]."
|9.||Etoposide (VP 16)FDA LinkGeneric
10/01/1998 - "The purpose of this study was to test the disease-controlling effect of low-dose oral etoposide monotherapy in adult-onset multisystem Langerhans cell histiocytosis. "
12/15/1988 - "Eighteen evaluable children with recurrent Langerhans' cell histiocytosis (LCH) which was resistant to standard therapy, were treated with etoposide (VP 16-213), 200 mg/m2/day for 3 days every 3 weeks, to study the efficacy and toxicity of this drug. "
12/15/1988 - "Etoposide in recurrent childhood Langerhans' cell histiocytosis: an Italian cooperative study."
01/01/2007 - "Adult Langerhans cell histiocytosis with independently relapsing lung and liver lesions that was successfully treated with etoposide."
07/01/2004 - "Although rare in children, the majority of therapy-related malignancies have been etoposide-related APL associated with Langerhans cell histiocytosis. "
02/01/1991 - "A comparison study of two methods of peanut agglutinin staining with S100 immunostaining in 29 cases of histiocytosis X."
07/01/1993 - "The diagnosis of histiocytosis X was made on the basis of the positive immunoperoxidase staining of the histiocytic cells with S-100 and peanut agglutinin (PNA) as well as the clinical picture. "
09/01/1992 - "In contrast, most histiocytosis X cells labeled for S100 protein and with LN3 and peanut agglutinin. "
03/01/1987 - "The usefulness of peanut agglutinin for the detection of histiocytosis-X and interdigitating reticulum cells."
08/01/1986 - "Based on this unique characteristic of Langerhans' cells, peanut agglutinin binding assay may represent a simple and inexpensive tool for morphologic differentiation of eosinophilic granuloma or other types of histiocytosis X from other monocytic and histiocytic lesions in equivocal cases."
|1.||Drug Therapy (Chemotherapy)
01/01/2012 - "She progressed from single system Langerhans cell histiocytosis to multisystem involvement and remains in long-term remission following chemotherapy."
04/01/2011 - "Recurrence of unifocal limbal Langerhans cell histiocytosis with partial response to chemotherapy and prolonged remission."
03/01/2001 - "We present the clinical, immunohistological and cytological features in a visceral type of adult Langerhans cell histiocytosis, which responded well to chemotherapy."
07/01/2000 - "The prognosis of children with multisystem Langerhans cell histiocytosis (LCH) has improved with the application of chemotherapy. "
02/10/1990 - "We report an adult patient with systemic Langerhans' cell histiocytosis (LHX), who was refractory to multiple chemotherapy courses and in whom a partial clinical and biological 3-month remission was achieved with alpha-2-interferon. "
01/01/2000 - "The use of radiotherapy in the treatment of Langerhans' cell histiocytosis was first reported in the literature in 1930 and has been proven as effective in numerous studies. "
06/01/2013 - "To analyze efficacy of radiotherapy for adult patients with Langerhans cell histiocytosis (LCH). "
06/01/2013 - "[Efficacy of radiotherapy for adult patients with Langerhans cell histiocytosis]."
11/01/2006 - "This patterns-of-care study was performed to define the current clinical experience with radiotherapy of Langerhans' cell histiocytosis in adults in Germany and to define open questions resulting from this study. "
11/01/2006 - "Radiotherapy of Langerhans' Cell Histiocytosis : Results and Implications of a National Patterns-of-Care Study."
04/01/2015 - "To investigate the salvage therapy for a child with refractory and ( or) repeatedly-relapsed Langerhans cell histiocytosis. "
12/15/2009 - "2'-Chlorodeoxyadenosine (2-CdA) as salvage therapy for Langerhans cell histiocytosis (LCH). "
11/01/2005 - "Salvage therapy for refractory Langerhans cell histiocytosis in children."
12/15/2009 - "A prospective phase II Histiocyte Society study, LCH-S-98, evaluated the efficacy of 2-chlorodeoxyadenosine (2-CdA) monotherapy as salvage therapy in Langerhans cell histiocytosis (LCH). "
04/01/2015 - "The effect of commonly used chemotherapeutic regimens is limited for children with refractory and (or) repeatedly-relapsed Langerhans cell histiocytosis and cladribine can be used as an alternative therapeutic option of the salvage therapy."
|4.||Hematopoietic Stem Cell Transplantation
05/01/2010 - "Improved outcome of refractory Langerhans cell histiocytosis in children with hematopoietic stem cell transplantation in Japan."
06/01/2003 - "The aim of this study was to assess the results of hematopoietic stem cell transplantation (HSCT) in refractory Langerhans cell histiocytosis (LCH). "
06/01/2003 - "Hematopoietic stem cell transplantation in patients with severe Langerhans cell histiocytosis and hematological dysfunction: experience of the French Langerhans Cell Study Group."
06/01/2014 - "Haploidentical parental hematopoietic stem cell transplantation in pediatric refractory Langerhans cell histiocytosis."
05/01/2009 - "Hematopoietic stem cell transplantation in Langerhans cell histiocytosis: case report and review of the literature."
|5.||Stem Cell Transplantation
08/01/2005 - "Improved outcome of treatment-resistant high-risk Langerhans cell histiocytosis after allogeneic stem cell transplantation with reduced-intensity conditioning."
06/01/2015 - "Haematopoietic stem cell transplantation for refractory Langerhans cell histiocytosis: outcome by intensity of conditioning."
10/01/2008 - "The use of reduced-intensity stem cell transplantation in haemophagocytic lymphohistiocytosis and Langerhans cell histiocytosis."
10/01/2007 - "Autologous stem cell transplantation for refractory Langerhans' cell histiocytosis."
01/01/2007 - "Importance of allogeneic T-cells for disease control after stem cell transplantation for high-risk Langerhans cell histiocytosis."