Histidine-tRNA Ligase

An enzyme that activates histidine with its specific transfer RNA. EC 6.1.1.21.

Also Known As:

His-tRNA Ligase; Histidyl-tRNA Synthetase; Jo-1 Antigen; Antigen, Jo-1; His tRNA Ligase; Histidine tRNA Ligase; Histidyl tRNA Synthetase; Jo 1 Antigen; Ligase, His-tRNA; Ligase, Histidine-tRNA; Synthetase, Histidyl-tRNA; Histidyl T RNA Synthetase; L-Histidine:tRNA(His) ligase (AMP-forming)

Networked: 84 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Carbon-Oxygen Ligases
      - Amino Acyl-tRNA Synthetases: 433
        Histidine-tRNA Ligase: 84
        S cerevisiae HTS1 protein

Experts

1.	Ascherman, Dana P: 5 articles (09/2015 - 12/2002)
2.	Antonellis, Anthony: 4 articles (01/2020 - 01/2013)
3.	Ridgway, William M: 3 articles (08/2013 - 09/2007)
4.	Francklyn, Christopher: 2 articles (01/2020 - 01/2018)
5.	Meyer-Schuman, Rebecca: 2 articles (01/2020 - 01/2018)
6.	Abbott, Jamie A: 2 articles (01/2018 - 01/2017)
7.	Baets, Jonathan: 2 articles (01/2018 - 08/2015)
8.	De Jonghe, Peter: 2 articles (01/2018 - 08/2015)
9.	Demeler, Borries: 2 articles (01/2018 - 01/2017)
10.	Züchner, Stephan: 2 articles (01/2018 - 01/2013)

Related Diseases

1.	Myositis (Idiopathic Inflammatory Myopathies) 01/01/2023 - "To better define interactive signaling networks in IIM, we characterized the cellular phenotype and transcriptomic profiles of muscle-infiltrating cells in our established murine model of histidyl-tRNA synthetase (HRS)-induced myositis. " 12/01/2012 - "Characterization of TLR4-mediated auto-antibody production in a mouse model of histidyl-tRNA synthetase-induced myositis." 04/01/2018 - "A recent work demonstrated that immunization of mice with histidyl-tRNA synthetase results in muscle inflammation consistent with myositis. " 01/01/2014 - "We characterized the performance of MRI in a well-established mouse model of myositis and the antisynthetase syndrome, based on the immunization of wild-type mice with the amino-terminal fragment of histidyl-tRNA synthetase (HisRS). " 01/01/1988 - "The Jo-1 antigen is a specific marker for autoimmune myositis with an excellent correlation with associated interstitial lung disease. "
2.	Interstitial Lung Diseases (Interstitial Lung Disease) 04/01/2011 - "The patient was diagnosed with ASS based on; positivity for anti-histidyl-tRNA synthetase (Jo-1) antibody, interstitial lung disease, polyarthritis, and mechanic's hands. " 01/01/1988 - "The Jo-1 antigen is a specific marker for autoimmune myositis with an excellent correlation with associated interstitial lung disease. " 07/11/2014 - "Inflammatory and debilitating myositis and interstitial lung disease are commonly associated with autoantibodies (anti-Jo-1 antibodies) to cytoplasmic histidyl-tRNA synthetase (HisRS). " 12/01/2011 - "The antisynthetase syndrome is characterized by the presence of myositis, interstitial lung disease, arthritis, Raynaud's phenomenon, mechanics hands and anti-Jo1 antibody (histidyl tRNA synthetase). " 03/01/1990 - "Studies have clearly associated anti-Jo-1, also directed at an aminoacyl-tRNA synthetase (histidyl-tRNA synthetase), with a subgroup of myositis marked by a high frequency of interstitial lung disease (ILD) and arthritis. "
3.	Arthritis (Polyarthritis) 04/01/2011 - "The patient was diagnosed with ASS based on; positivity for anti-histidyl-tRNA synthetase (Jo-1) antibody, interstitial lung disease, polyarthritis, and mechanic's hands. " 12/01/2011 - "The antisynthetase syndrome is characterized by the presence of myositis, interstitial lung disease, arthritis, Raynaud's phenomenon, mechanics hands and anti-Jo1 antibody (histidyl tRNA synthetase). " 03/01/1990 - "Studies have clearly associated anti-Jo-1, also directed at an aminoacyl-tRNA synthetase (histidyl-tRNA synthetase), with a subgroup of myositis marked by a high frequency of interstitial lung disease (ILD) and arthritis. "
4.	Gonadal dysgenesis XX type deafness 01/01/2021 - "In this study, we showed that histidyl-tRNA synthetase HARS2, whose deficiency is associated with Perrault syndrome 2 (PRLTS2), is robustly expressed in postnatal mouse cochlea including the outer and inner hair cells. " 04/19/2011 - "Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome." 04/04/2013 - "Together with the previous identification of mutations in HARS2, encoding mitochondrial histidyl-tRNA synthetase, mutations in CLPP expose dysfunction of mitochondrial protein homeostasis as a cause of Perrault syndrome." 04/19/2011 - "In a nonconsanguineous family with five affected siblings, linkage analysis and genomic sequencing revealed the genetic basis of Perrault syndrome to be compound heterozygosity for mutations in the mitochondrial histidyl tRNA synthetase HARS2 at two highly conserved amino acids, L200V and V368L. "
5.	Carcinoma (Carcinomatosis) 12/01/1996 - "The present study was designed to determine the subcellular localization of histidyl-tRNA synthetase (Jo-1) in human laryngeal epithelial carcinoma cell line (HEp-2 cells). " 12/01/1996 - "Localization of histidyl-tRNA synthetase (Jo-1) in human laryngeal epithelial carcinoma cell line (HEp-2 cells)."

Related Drugs and Biologics

1.	Jo-1 antibody
2.	Antigens
3.	Epitopes
4.	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)
5.	Autoantibodies
6.	Antibodies
7.	Histidine-tRNA Ligase
8.	Proteins (Proteins, Gene)
9.	Transfer RNA (tRNA)
10.	Ligases (Synthetase)