Histidinol

The penultimate step in the pathway of histidine biosynthesis. Oxidation of the alcohol group on the side chain gives the acid group forming histidine. Histidinol has also been used as an inhibitor of protein synthesis.

Also Known As:

Networked: 40 relevant articles (6 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fang, Wei D: 1 article (04/2003)
2.	Hilchey, Jeffrey L: 1 article (04/2003)
3.	Norum, Joanne N: 1 article (04/2003)
4.	Warrington, Robert C: 1 article (04/2003)
5.	Watt, Connie: 1 article (04/2003)

Related Diseases

1.	Neoplasms (Cancer) 05/01/1992 - "L-histidinol improves the selectivity and the efficacy of a variety of cancer drugs in several transplantable murine tumors. " 11/01/1996 - "L-Histidinol protects normal cells from various anticancer drugs, while enhancing the toxicity of the same agents in drug-sensitive and multidrug-resistant tumor cells. " 11/01/1996 - "L-Histidinol protects normal cells from anticancer drugs while enhancing the ability of these agents to eradicate tumor cells. " 05/01/1992 - "Furthermore, L-histidinol circumvents the drug-resistant traits of a variety of cancer cells, including those showing multidrug resistance. " 05/01/1986 - "A novel approach for improving the efficacy of experimental cancer chemotherapy using combinations of anticancer drugs and L-histidinol."
2.	Melanoma (Melanoma, Malignant) 09/01/1991 - "Improved treatment of disseminated B16f10 melanoma in mice with anticancer drugs in combination with L-histidinol." 09/01/1991 - "In this study, the effects of L-histidinol on the viability, cell cycle traverse and anticancer drug susceptibility of B16f10 melanoma cells in culture have been examined. " 04/01/2003 - "These experiments reveal that L-histidinol is pro-apoptotic in CCRF-CEM cells, accentuates markedly the apoptotic response otherwise elicited by CAM in murine B16f10 melanoma cells and inhibits CAM-induced apoptosis in normal 3T3 fibroblasts." 09/01/1991 - "L-Histidinol, on its own, was found to have a significant and dose-dependent capacity to reduce the number of lung foci and to extend survival of animals bearing disseminated B16f10 melanoma. " 09/01/1991 - "L-Histidinol inhibited the transit of B16f10 melanoma cells through the cell cycle in a dose-dependent manner. "
3.	Leukopenia 01/01/1987 - "The results of these studies indicate that the administration of L-histidinol can protect the CD8F1 mouse from FUra-associated leukopenia, body weight loss, and ultimately, from mortality. " 12/01/1988 - "In the BALB/c x DBA/8 F1 (hereafter called CD8F1) murine tumor system, L-histidinol protected mice from FUra-induced leukopenia, weight loss, and mortality; however, the therapeutic index was not improved since L-histidinol also protected the tumor against the toxic effects of FUra. "
4.	Leukemia L1210 05/01/1985 - "Accordingly, DBA/2J mice were given iv injections of 1 X 10(6) L1210 leukemia cells 3 days before histidinol-anticancer drug treatments. " 07/01/1984 - "Histidinol-mediated improvement in the specificity of 1-beta-D-arabinofuranosylcytosine and 5-fluorouracil in L 1210 leukemia-bearing mice." 01/01/1987 - "Thus, in the presence of L-histidinol, the toxicity of a proliferation-dependent drug such as 5-fluorouracil (FUra) was found to be reduced in normal tissue cells of the DBA/2J mouse, but not in L1210 leukemia cells in the same mouse. " 02/15/1989 - "In contrast, both L1210 leukemia cells and colon 26 adenocarcinoma cells were more efficiently killed by combinations of L-histidinol and cisplatin. " 07/01/1984 - "We report also that the histidinol-mediated protection to bone marrow cells persists in L1210 leukemia-bearing DBA/2J mice treated with combinations of histidinol and 1-beta-D-arabinofuranosylcytosine or 5-fluorouracil without diminishing the toxicities of these agents for in situ leukemia cells."
5.	Weight Loss (Weight Reduction) 09/01/1991 - "In contrast, L-histidinol prevented the weight loss, death and bone marrow damage otherwise resulting from identical doses of FUra. " 12/01/1988 - "In the BALB/c x DBA/8 F1 (hereafter called CD8F1) murine tumor system, L-histidinol protected mice from FUra-induced leukopenia, weight loss, and mortality; however, the therapeutic index was not improved since L-histidinol also protected the tumor against the toxic effects of FUra. "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Cytarabine (Cytosar-U)
3.	Cisplatin (Platino)
4.	Carmustine (FIVB)
5.	Melphalan (Alkeran)
6.	Cyclophosphamide (Cytoxan)
7.	Histidine (L-Histidine)
8.	Proteins (Proteins, Gene)
9.	Antineoplastic Agents (Antineoplastics)
10.	Essential Amino Acids

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Antineoplastic Combined Chemotherapy Protocols
3.	Injections