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von Hippel-Lindau Disease (von Hippel Lindau Disease)

An autosomal dominant disorder caused by mutations in a tumor suppressor gene. This syndrome is characterized by abnormal growth of small blood vessels leading to a host of neoplasms. They include HEMANGIOBLASTOMA in the RETINA; CEREBELLUM; and SPINAL CORD; PHEOCHROMOCYTOMA; pancreatic tumors; and renal cell carcinoma (see CARCINOMA, RENAL CELL). Common clinical signs include HYPERTENSION and neurological dysfunctions.
Also Known As:
von Hippel Lindau Disease; von Hippel-Lindau Syndrome; Cerebelloretinal Angiomatosis, Familial; Angiomatosis Retinae; Familial Cerebello-Retinal Angiomatosis; Hippel-Lindau Disease; Lindau's Disease; VHL Syndrome; Angiomatoses, Familial Cerebello-Retinal; Angiomatoses, Familial Cerebelloretinal; Angiomatosis, Familial Cerebello-Retinal; Angiomatosis, Familial Cerebelloretinal; Cerebello-Retinal Angiomatoses, Familial; Cerebello-Retinal Angiomatosis, Familial; Cerebelloretinal Angiomatoses, Familial; Familial Cerebello Retinal Angiomatosis; Familial Cerebello-Retinal Angiomatoses; Familial Cerebelloretinal Angiomatoses; Familial Cerebelloretinal Angiomatosis; Hippel Lindau Disease; Lindau's Diseases; Lindaus Disease; VHL Syndromes; von Hippel Lindau Syndrome; Lindau Disease
Networked: 678 relevant articles (8 outcomes, 48 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Hemangioblastoma
3. Renal Cell Carcinoma (Grawitz Tumor)
4. Primitive Neuroectodermal Tumors (PNET)
5. Thrombotic Thrombocytopenic Purpura

Experts

1. Linehan, W Marston: 15 articles (12/2021 - 05/2004)
2. Chew, Emily Y: 13 articles (12/2021 - 02/2007)
3. Pacak, Karel: 12 articles (12/2021 - 02/2005)
4. Richard, Stéphane: 11 articles (10/2018 - 02/2002)
5. Wong, Wai T: 8 articles (12/2021 - 02/2007)
6. Neumann, Hartmut P H: 8 articles (09/2012 - 02/2002)
7. Eisenhofer, Graeme: 8 articles (05/2012 - 02/2005)
8. Jonasch, Eric: 7 articles (04/2022 - 02/2009)
9. Maher, Eamonn R: 6 articles (01/2022 - 07/2002)
10. Giraud, Sophie: 6 articles (10/2018 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to von Hippel-Lindau Disease:
1. Retinaldehyde (Retinal)IBA
2. Sunitinib (Sutent)FDA Link
3. CatecholaminesIBA
4. Bevacizumab (Avastin)FDA Link
5. Cefepime (Maxipime)FDA LinkGeneric
6. EverolimusFDA Link
7. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
8. Succinate Dehydrogenase (Fumarate Reductase)IBA
9. DNA (Deoxyribonucleic Acid)IBA
10. Messenger RNA (mRNA)IBA

Therapies and Procedures

1. Light Coagulation
2. Lasers (Laser)
3. Nephrectomy
4. Radiofrequency Ablation
5. Renal Dialysis (Hemodialysis)