|1.||Kang, Jung Hun: 3 articles (07/2015 - 03/2012)|
|2.||Bruera, Eduardo: 3 articles (07/2015 - 03/2012)|
|3.||Petroianu, Georg A: 3 articles (01/2015 - 06/2007)|
|4.||Aielli, Federica: 3 articles (12/2013 - 09/2003)|
|5.||Porzio, Giampiero: 3 articles (12/2013 - 09/2003)|
|6.||Fasnacht, Kathleen S: 2 articles (12/2015 - 06/2015)|
|7.||Stewart, Jonathan T: 2 articles (12/2015 - 06/2015)|
|8.||Sheyner, Inna: 2 articles (12/2015 - 06/2015)|
|9.||Moon, Seok Whan: 2 articles (11/2015 - 06/2013)|
|10.||Sa, Young Jo: 2 articles (11/2015 - 06/2013)|
03/01/2010 - "We conclude that a single dose of baclofen is a good treatment for intractable hiccups."
12/01/1992 - "There was a consistent and statistically significant (p = 0.03) improvement in hiccup severity with Baclofen, both subjectively (p = 0.03) and by hiccup-free periods (p = 0.003). "
02/01/1995 - "Also, if controlled studies confirm our encouraging results, baclofen can be a major element in the treatment of chronic hiccup that is idiopathic, or that cannot be helped by treatment of gastro-oesophageal diseases."
10/01/2001 - "Baclofen is effective in intractable hiccups induced by brainstem lesions."
08/01/1998 - "The efficacy of baclofen in the treatment of chronic hiccup is demonstrated in two cases. "
|2.||gabapentin (Neurontin)FDA LinkGeneric
05/01/2012 - "The hiccups were dramatically relieved by oral Gabapentin, highlighting the recent reports that mention this molecule as being useful for hiccups. "
12/01/2011 - "Gabapentin (100 mg twice daily) was then prescribed and within 24 hours of the start of that treatment, the hiccups had resolved completely. "
06/01/2013 - "To determine whether gabapentin is effective in the treatment of persistent or intractable hiccups. "
05/01/2007 - "Gabapentin withdrawal led to reappearance of hiccup, which improved again after its reintroduction. "
05/01/2007 - "To report a patient with intractable hiccup which improved with gabapentin. "
|3.||Chlorpromazine (Thorazine)FDA Link
12/01/2007 - "Chlorpromazine, the only Food and Drug Administration-approved agent specifically indicated for hiccups, is often chosen as a first-line treatment. "
03/01/2008 - "Chlorpromazine, the first-line treatment of intractable hiccups, is contraindicated in PD. "
01/01/2014 - "We present the case of a 75 old male with rebellious hiccup which prevented him to fall asleep by day or by night, associated with belches lasting for three years, refractory to chlorpromazine. "
11/26/2005 - "Chlorpromazine is the only drug that is registered for the treatment of persistent hiccups but it has many side effects. "
03/01/2005 - "Injection of compound chlorpromazine into Yintang (Ex-HN 3) has a significant therapeutic effect on obstinate hiccup."
|4.||Metoclopramide (Reglan)FDA LinkGeneric
12/01/2014 - "This study aimed to assess the feasibility efficacy of metoclopramide in the treatment of patients with intractable hiccups. "
12/01/2014 - "Limited data exist regarding the efficacy of metoclopramide in the treatment of intractable hiccups. "
12/01/2014 - "Metoclopramide appears to be a promising candidate for the treatment of patients with intractable hiccups, with mild adverse events. "
12/01/2014 - "Metoclopramide for patients with intractable hiccups: a multicentre, randomised, controlled pilot study."
06/01/2014 - "His hiccups recurred and were treated unsuccessfully with metoclopramide in the emergency department. "
|5.||Antipsychotic Agents (Antipsychotics)IBA
05/01/2014 - "Antipsychotics are thought to be effective in the treatment of hiccups; however, they have rarely been reported to induce hiccups. "
07/01/2011 - "Antipsychotics are thought to be effective in the treatment of hiccups; however, they are rarely reported to induce hiccups. "
01/01/2015 - "This is one of few case reports in which two antipsychotics were challenged for a single patient with hiccups, and the effects of the drugs were obviously different. "
12/01/2014 - "As diagnosis of poststroke hiccups was assumed, the patient was treated over the next 6 months with adequate doses of various antipsychotic drugs commonly used for the treatment of hiccups; however, all were discontinued because of adverse effects. "
12/01/2014 - "Highlighting the uncertainty related to drug-induced hiccups is the fact that multiple antipsychotics have been reported to not only induce hiccups but also to alleviate them. "
|6.||Dexamethasone (Maxidex)FDA LinkGeneric
01/01/2013 - "Transient hiccups associated with oral dexamethasone."
01/01/2013 - "Compared with baseline values, hiccup intensity (NRS: 5.24 vs. 2.44) and duration (66.43 minutes vs. 22.00 minutes) were significantly attenuated after dexamethasone re-administration. "
01/01/2013 - "Of these 34 patients, 25 (73.5%) had recurrence of hiccups after dexamethasone re-administration. "
03/01/2012 - "In this case series, we present five patients who developed hiccups after receiving dexamethasone for CINV. "
03/01/2012 - "Corticosteroid rotation to alleviate dexamethasone-induced hiccup: a case series at a single institution."
|7.||Midazolam (Versed)FDA LinkGeneric
07/01/1996 - "Intravenous midazolam 5-10 mg rapidly relieved the hiccup. "
07/21/2012 - "Midazolam was significantly associated with an increased risk of hiccups. "
07/21/2012 - "The sedated patients who received 2 mg midazolam developed hiccups more frequently compared to those receiving 1 mg midazolam (P = 0.0028). "
03/01/2012 - "Hiccups induced by midazolam during sedation in flexible bronchoscopy."
03/01/2005 - "Midazolam for long-term treatment of intractable hiccup."
|8.||aprepitant (Emend)FDA Link
08/01/2013 - "Our analysis indicated that aprepitant was not a major risk factor for the onset of hiccups in the high CDDP dose group(≥70 mg/m(2)). "
08/01/2013 - "However, it is not known how the onset of hiccups takes place in antiemetic therapy including aprepitant according to the guideline. "
03/01/2010 - "Most common adverse effects reported by patients receiving aprepitant were hiccups (33%) and drowsiness (33%). "
08/01/2013 - "In conclusion, we suggest that aprepitant is effective for CINV, without causing the onset of hiccups in patients treated with high-dose CDDP-based chemotherapy."
01/01/2004 - "Other adverse events experienced by aprepitant recipients include anorexia, constipation, diarrhoea, nausea (after day 5 of the study) and hiccups. "
|9.||Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
|10.||Acetic Acid (Vinegar)FDA LinkGeneric
05/01/2015 - "This case report describes a patient whose persistent hiccups significantly improved with the use of vinegar. "
05/01/2015 - "Hiccups stopped or decreased in intensity or in rate per minute after sipping vinegar. "
05/01/2007 - "We believe that intranasal vinegar administration could be a useful nonpharmacologic therapy to cease intractable hiccup."
05/01/2007 - "Intranasal vinegar might stimulate dorsal wall of nasopharynx where the pharyngeal branch of the glossopharyngeal nerve, which is thought as an afferent of the reflex arch of hiccup, is distributed. "
05/01/2007 - "Although the hiccup was resistant to conventional medications, the nose drops of small amount of vinegar showed a favorable effect on the hiccup. "
07/01/1996 - "The present case is a young adult who had severe almost continuous hiccups for 3 years after placement of a feeding gastrostomy and Nissen fundoplication. "
08/01/1989 - "The patient underwent Nissen fundoplication, which improved his heartburn but not his hiccups. "
07/01/2002 - "We report a case of a 31-year-old patient who suffered from intractable hiccup starting 3 weeks after laparoscopic Nissen fundoplication for GERD, a potential surgical complication that has not been described. "
07/01/2002 - "Intractable hiccup: an odd complication after laparoscopic fundoplication for gastroesophageal reflux disease."
07/01/1984 - "After all attempts failed to relieve his hiccups, a Nissen fundoplication relieved heartburn, healed the esophagitis, and stopped excessive reflux of acid gastric juice, even though the hiccups persisted. "
|2.||Vagus Nerve Stimulation
07/01/2010 - "Refractory central supratentorial hiccup partially relieved with vagus nerve stimulation."
01/01/2015 - "The recent introduction of electrical vagus nerve stimulation for therapy-resistant hiccup is the ultimate compliment to these pioneers."
06/01/2011 - "Treatment of persistent hiccups with transcutaneous phrenic and vagal nerve stimulation."
05/01/2005 - "Vagus nerve stimulation for chronic intractable hiccups. "
01/01/2013 - "Vagus nerve stimulation could be beneficial in many other conditions, including heart failure, tinnitus, chronic hiccups, Alzheimer's disease and inflammatory diseases. "
|3.||Drug Therapy (Chemotherapy)
07/01/2015 - "Hiccups during Chemotherapy: What Should We Do?"
08/01/2013 - "[A search for the risk factors for hiccups and evaluation of antiemetic therapy in CDDP-based chemotherapy, using cluster analysis]."
08/01/2013 - "The endeavoring battle against multi drug resistant TB, multiple dosing, their prominent side effects and bioavailability hiccups related to fixed dose combinations has undeniably become a Herculean task indicating rigorous research requirement in anti TB drug therapy. "
01/01/2013 - "So far, no cases reporting high doses of prokinetics to treat persistent hiccups after chemotherapy have been published. "
01/01/2013 - "High dose of prokinetics for refractory hiccups after chemotherapy or the return to a simple drug."
01/01/1989 - "The observations made before induction of anesthesia are presented in Table 3. The children in group II exhibited significantly greater (P less than 0.05) slurred speech than those in group I. A low incidence of hiccup was seen in both groups. "
08/01/2002 - "Anesthesia as therapy for persistent hiccups."
06/22/2001 - "[Short-term anesthesia to stop persistent hiccups]."
10/01/1995 - "Six episodes of coughing and hiccoughs occurred after the end of anesthesia. "
02/01/1991 - "Termination of hiccups occurring under anesthesia."
|5.||Acupuncture Points (Acupuncture Point)
01/01/2008 - "Efficacy of near-infrared irradiation on intractable hiccup in custom-set acupoints: evidence-based analysis of treatment outcome and associated factors."
08/01/2006 - "Resolution of intractable hiccups after near-infrared irradiation of relevant acupoints."
03/01/2005 - "Eventually, the hiccups were rapidly terminated by acupuncture at acupoint GV14 (Da zhui). "
04/01/2012 - "The acupoint injection therapy has some obvious advantages in the treatment of clinical conditions or illness of the internal medicine and surgical problems, especially for hiccup and backlog pain. "
08/01/2006 - "We describe two stroke patients with intractable hiccups that were refractory to pharmacological treatment but were well resolved by application to relevant acupoints with the modality linear polarized near-infrared ray equipment on PC 6 (Nei Guan), ST 36 (Zu San Li), and DU 9 (Chih Yang), which are the empirical acupoints aimed at regulating gastrointestinal mobility and function of the thoracic organ. "