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Fructose-Bisphosphatase

An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-phosphate and orthophosphate. EC 3.1.3.11.
Also Known As:
D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase; FDPase; Fructose-1,6-Biphosphatase; 1-Phosphohydrolase, D-Fructose-1,6-Bisphosphate; D Fructose 1,6 Bisphosphate 1 Phosphohydrolase; Fructose 1,6 Biphosphatase; Fructose 1,6 Bisphosphatase; Fructose 1,6 Diphosphatase; Fructose Bisphosphatase; Fructose-1,6-Bisphosphatase; Fructose-1,6-Diphosphatase; Fructosediphosphatase; Hexosediphosphatase
Networked: 197 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Andrikopoulos, Sofianos: 4 articles (10/2012 - 06/2006)
2. Fam, Barbara C: 4 articles (10/2012 - 06/2006)
3. Keith, Brian: 3 articles (05/2020 - 09/2014)
4. Li, Bo: 3 articles (05/2020 - 09/2014)
5. Mancuso, Anthony: 3 articles (05/2020 - 09/2014)
6. Nissim, Itzhak: 3 articles (05/2020 - 09/2014)
7. Simon, M Celeste: 3 articles (05/2020 - 09/2014)
8. Huang, Haojie: 3 articles (01/2020 - 01/2017)
9. Jin, Xin: 3 articles (01/2020 - 01/2017)
10. Chiang, Hui-Ling: 3 articles (08/2013 - 10/2005)

Related Diseases

1. Insulin Resistance
01/01/2023 - "1α,25(OH)2D3 ameliorates insulin resistance by alleviating γδ T cell inflammation via enhancing fructose-1,6-bisphosphatase 1 expression."
11/01/2008 - "Fructose-1,6-bisphosphatase (FBPase) is a regulated enzyme in gluconeogenesis that is increased in animal models of obesity and insulin resistance. "
01/01/2021 - "When insulin resistance is induced by diets, a greater activation of insulin signaling cascade has been reported, increased cardiotrophin-1 levels and liver glucokinase and glucose- 6-phosphatase activities, and a decreased fructose-1,6-biphosphatase activity. "
01/01/2018 - "5' AMP-activated protein kinase (AMPK) activation improves insulin sensitivity by enhancing glucose uptake (via increased glucose transporter type 4 [GLUT4] translocation and activation of the extracellular signal-regulated kinase [ERK]/ atypical protein kinase C [aPKC] pathway), and increasing fatty acid oxidation (via inhibition of acetyl-CoA carboxylase 1 [ACC]), while downregulating gluconeogenesis (via induction of small heterodimer partner [SHP] and subsequent downregulation of the gluconeogenic enzymes: phosphoenolpyruvate carboxykinase [PEPCK], glucose 6-phosphatase [G6PASE], fructose- 1,6-bisphosphatase 1 [FBP1], and forkhead box protein 1 [FOXO1]). "
01/01/2020 - "The administration of AA elicited a significant decrease in the levels of plasma glucose, insulin resistance, HbA1c, urea, uric acid, creatinine, glycogen, glycogen synthase, glucose-6- phosphatase, and fructose-1,6-bisphosphatase and a significant increase of body weight development, insulin, Hb, hexokinase, and glycogen phosphorylase and mRNA expressions of insulin signaling molecule like insulin receptor 1, insulin receptor 2 and glucose transporter-4 in the STZ-NAD induced diabetic rats. "
2. Body Weight (Weight, Body)
01/01/2006 - "betle (75 and 150 mg/kg of body weight) for 30 days resulted in significant reduction in blood glucose (from 205.00 +/- 10.80 mg/dL to 151.30 +/- 6.53 mg/dL) and glycosylated hemoglobin and decreased activities of liver glucose-6-phosphatase and fructose-1,6-bisphosphatase, while liver hexokinase increased (P < .05), in STZ diabetic rats when compared with untreated diabetic rats. "
01/01/2006 - "Intraperitoneal administration of UMB (10, 20, and 30 mg/kg of body weight) and glibenclamide (600 micro g/kg of body weight) in 10% dimethyl sulfoxide dissolved in water, for 45 days, produced significantly decreased levels of blood glucose and HbA(1c) and activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase, while elevating levels of plasma insulin, Hb, and liver glycogen and activities of glucokinase and glucose-6-phosphate dehydrogenase to near normal levels in STZ-diabetic rats when compared with normal control rats. "
11/01/2001 - "The levels of glycogen in brain, lactate and acetoacetate in brain and plasma, glucose in plasma and the activities of brain key enzymes of glycogen metabolism (glycogen phosphorylase, GPase, glycogen synthetase, GSase), gluconeogenesis (fructose 1,6-bisphosphatase, FBPase), and glycolysis (6-phosphofructo 1-kinase, PFK) were evaluated in rainbow trout, Oncorhynchus mykiss, from 0.5 to 3 hr after intraperitoneal injection of 1 ml/kg(-1) body weight of saline alone (controls) or containing bovine glucagon at three different doses: 10, 50, and 100 ng/g(-1) body weight. "
09/01/1985 - "The effects of a 100 g/kg diet substitution of bagasse on the body-weight gain, food consumption and faecal dry weight of mice given a high-sucrose diet and on the activities of hepatic glucose-6-phosphate dehydrogenase (EC I.I.I.49), 6-phosphogluconate dehydrogenase (EC I.I.I.44), malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (EC I.I.I.40), ATP-citrate (pro-3S) lyase (EC 4.I.3.8), 6-phosphofructokinase EC 2.7.I.II), pyruvate kinase (EC 2.7.I.40) and fructose-1,6-bisphosphatase (EC 3.I.3.II) were studied. "
01/01/2020 - "The administration of AA elicited a significant decrease in the levels of plasma glucose, insulin resistance, HbA1c, urea, uric acid, creatinine, glycogen, glycogen synthase, glucose-6- phosphatase, and fructose-1,6-bisphosphatase and a significant increase of body weight development, insulin, Hb, hexokinase, and glycogen phosphorylase and mRNA expressions of insulin signaling molecule like insulin receptor 1, insulin receptor 2 and glucose transporter-4 in the STZ-NAD induced diabetic rats. "
3. Inflammation (Inflammations)
4. Neoplasms (Cancer)
5. Hypoglycemia (Reactive Hypoglycemia)

Related Drugs and Biologics

1. Glucose-6-Phosphatase (Glucose 6 Phosphatase)
2. Hexokinase
3. Blood Glucose (Blood Sugar)
4. Glycated Hemoglobin (Glycosylated Hemoglobin)
5. hydroxide ion
6. Enzymes
7. Glycogen
8. Fructose
9. Proteins (Proteins, Gene)
10. Cytostatic Agents

Related Therapies and Procedures

1. Therapeutics
2. Kidney Transplantation
3. Intraperitoneal Injections
4. Fluid Therapy (Oral Rehydration Therapy)