Hexestrol

A synthetic estrogen that has been used as a hormonal antineoplastic agent.

Also Known As:

Hexestrol, (R*,R*)-(+-)-Isomer; Hexestrol, (R*,S*)-Isomer; Hexestrol, (R-(R*,R*))-Isomer; Hexestrol, (S-(R*,R*))-Isomer; Dihydrodiethylstilbestrol; Phenol, 4,4'-(1,2-diethyl-1,2-ethanediyl)bis-

Networked: 29 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        Stilbenes: 657
        Dihydrostilbenoids: 5
        Hexestrol: 29
        dihydrodibutylstilbestrol: 38
        hexestrol bis(diethylaminoethyl ether): 7
        hexestrol diphosphate: 4
        2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane: 2
        NSC 297170: 2
        benzestrol: 1
        bis(bromoacetyl)hexestrol: 1
        hexestrol diacetate: 1
        1,1,2,2-tetramethyl-1,2-bis(4'-hydroxyphenyl)ethane
        1,2-dipropyl-1,2-bis(3'-hydroxyphenyl)ethane
        1-bromohexestrol
        1-fluoro-norhexestrol
        1-fluorohexestrol
        1-iodohexestrol
        2-fluorohexestrol
        3',4'-hexestrol quinone
        3'-hydroxyhexestrol
        3,3'-dihydroxy-alpha,beta-diethyldiphenylethane
        3-(cyclohex-3-en-1-on-4-yl)-4-(4-hydroxyphenyl)hexane
        4,4-bis(acetylsarcosyl)synestrol
        bifluranol
        bromonorhexestrol
        butestrol
        hexestrol diazirine
        hexestrol dibromoacetate
        hexestrol dicaprylate
        hexestrol dimethyl ether
        iodonorhexestrol
        methestrol
        NSC 297169
        perhydrodiketohexestrol
        perhydrohexestrol
        phenestrol
        Stilbestrols: 1
        Hexestrol: 29
        dihydrodibutylstilbestrol: 38
        hexestrol bis(diethylaminoethyl ether): 7
        hexestrol diphosphate: 4
        2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane: 2
        NSC 297170: 2
        benzestrol: 1
        bis(bromoacetyl)hexestrol: 1
        hexestrol diacetate: 1
        1,1,2,2-tetramethyl-1,2-bis(4'-hydroxyphenyl)ethane
        1,2-dipropyl-1,2-bis(3'-hydroxyphenyl)ethane
        1-bromohexestrol
        1-fluoro-norhexestrol
        1-fluorohexestrol
        1-iodohexestrol
        2-fluorohexestrol
        3',4'-hexestrol quinone
        3'-hydroxyhexestrol
        3,3'-dihydroxy-alpha,beta-diethyldiphenylethane
        3-(cyclohex-3-en-1-on-4-yl)-4-(4-hydroxyphenyl)hexane
        4,4-bis(acetylsarcosyl)synestrol
        bifluranol
        bromonorhexestrol
        butestrol
        hexestrol diazirine
        hexestrol dibromoacetate
        hexestrol dicaprylate
        hexestrol dimethyl ether
        iodonorhexestrol
        methestrol
        NSC 297169
        perhydrodiketohexestrol
        perhydrohexestrol
        phenestrol
        Benzyl Compounds: 2
        Bibenzyls: 16
        Dihydrostilbenoids: 5
        Hexestrol: 29
        dihydrodibutylstilbestrol: 38
        hexestrol bis(diethylaminoethyl ether): 7
        hexestrol diphosphate: 4
        2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane: 2
        NSC 297170: 2
        benzestrol: 1
        bis(bromoacetyl)hexestrol: 1
        hexestrol diacetate: 1
        1,1,2,2-tetramethyl-1,2-bis(4'-hydroxyphenyl)ethane
        1,2-dipropyl-1,2-bis(3'-hydroxyphenyl)ethane
        1-bromohexestrol
        1-fluoro-norhexestrol
        1-fluorohexestrol
        1-iodohexestrol
        2-fluorohexestrol
        3',4'-hexestrol quinone
        3'-hydroxyhexestrol
        3,3'-dihydroxy-alpha,beta-diethyldiphenylethane
        3-(cyclohex-3-en-1-on-4-yl)-4-(4-hydroxyphenyl)hexane
        4,4-bis(acetylsarcosyl)synestrol
        bifluranol
        bromonorhexestrol
        butestrol
        hexestrol diazirine
        hexestrol dibromoacetate
        hexestrol dicaprylate
        hexestrol dimethyl ether
        iodonorhexestrol
        methestrol
        NSC 297169
        perhydrodiketohexestrol
        perhydrohexestrol
        phenestrol

Experts

1.	Bian, Lu: 1 article (01/2022)
2.	Cheng, Xingbo: 1 article (01/2022)
3.	Gao, Yanzheng: 1 article (01/2022)
4.	Han, Zhibin: 1 article (01/2022)
5.	Jia, Yulong: 1 article (01/2022)
6.	Lian, Xiaoyu: 1 article (01/2022)
7.	Liu, Binfeng: 1 article (01/2022)
8.	Liu, Zhendong: 1 article (01/2022)
9.	Ren, Zhishuai: 1 article (01/2022)
10.	Wang, Hongbo: 1 article (01/2022)

Related Diseases

1.	Infections 03/01/2023 - "In this study, we repurposed hexestrol (HXS) as an antibacterial agent to fight planktonic and biofilm-related MRSA infections. " 01/01/1982 - "In the purpose of establishing if the antiestrogens may inhib the protective effects of the estrogens during an experimental infection with Schistosoma mansoni in golden female hamster, we have studied the following estrogen-anti-estrogen associations: 17 beta-estradiol + trans-tamoxifène, 17 beta-estradiol + trans-clomifène, hexestrol + trans-tamoxifène. "
2.	Breast Neoplasms (Breast Cancer) 05/01/1962 - "[Regression of metastases from breast cancer induced by hexestrol]." 01/01/1962 - "Metastalysis syndrome and effectiveness of subcutaneous implantation of hexestrol in the treatment of breast cancer metastases." 10/01/1987 - "We have synthesized three nitrosourea derivatives of estradiol or hexestrol, and compared the ER binding affinity and cytotoxic activity of these compounds against ER-positive and -negative breast cancer cell lines in vitro. " 05/01/1983 - "High dose administration of Hexestrol of Medroxyprogesterone acetate was occasionally effective for ER-negative human and rat breast cancer, which suggests that there is another endocrinological tumor suppressing mechanism besides the mechanism involving the estrogen-ER system." 08/01/1981 - "The effects of hexestrol (HXS), medroxyprogesterone acetate (MAP) and chlormadinone acetate (CMA) on 7, 12-dimethylbenz [a] anthracene-induced mammary cancer in rats were evaluated. "
3.	Neoplasms (Cancer) 06/01/1980 - "In mature rats bearing DMBA-induced mammary tumors, selective uptake by the uterus and tumors is seen with 1-fluoro[3H4]hexestrol and o-fluoro[3H3]hexestrol. " 05/01/1983 - "High dose administration of Hexestrol of Medroxyprogesterone acetate was occasionally effective for ER-negative human and rat breast cancer, which suggests that there is another endocrinological tumor suppressing mechanism besides the mechanism involving the estrogen-ER system." 01/01/1990 - "Infiltrating cancers were identified in 80% of animals exposed to diethylstilbestrol, 17 beta-estradiol, and hexestrol for periods of 5.3-6.4 months; however hamsters exposed to ethinyl estradiol for comparable times did not develop any tumors. " 11/01/1983 - "These data represent the first detailed analysis of the relative carcinogenic activity of different estrogens within a given tumor-inducing system, and based on the carcinogenicity data of hexestrol and alpha-dienestrol presented herein, they suggest that epoxidation of the olefinic double bond and the p-quinone metabolite of DES probably are not involved significantly in its carcinogenic activity. " 11/01/2006 - "Oxidation of catechols to semiquinones and quinones is a mechanism of tumor initiation not only for endogenous estrogens, but also for synthetic estrogens such as hexestrol and diethylstilbestrol, a human carcinogen. "
4.	Glioma (Gliomas) 01/01/2022 - "Some small-molecule drugs were identified, such as hexestrol, which may specifically inhibit ITGB3BP and be useful in the treatment of glioma. "
5.	Neoplasm Metastasis (Metastasis) 05/01/1962 - "[Regression of metastases from breast cancer induced by hexestrol]." 01/01/1962 - "Metastalysis syndrome and effectiveness of subcutaneous implantation of hexestrol in the treatment of breast cancer metastases." 04/01/1974 - "Effect of calcitonin and hexestrol on urinary excretion of hydroxyproline in a patient with prostatic cancer and bone metastases."

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Estradiol (Delestrogen)
3.	Medroxyprogesterone Acetate (Depo-Provera)
4.	Estrogen Receptor Modulators (Antiestrogen)
5.	Anti-Bacterial Agents (Antibiotics)
6.	Diethylstilbestrol (Stilbestrol)
7.	Estradiol Congeners (Synthetic Estrogens)
8.	Dienestrol
9.	Fluorouracil (Carac)
10.	Catechols