Hexadimethrine Bromide

A synthetic polymer which agglutinates red blood cells. It is used as a heparin antagonist.

Also Known As:

1,5-Dimethyl-1,5-Diazaundecamethylene Polymethobromide; Polybrene; Bromide, Hexadimethrine; Hexadimethrine; 1,6-Hexanediamine, N,N,N',N'-tetramethyl-, polymer with 1,3-dibromopropane

Networked: 113 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Somsen, Govert W: 3 articles (07/2009 - 03/2004)
2.	de Jong, Gerhardus J: 3 articles (07/2009 - 03/2004)
3.	Kang, Jingwu: 2 articles (01/2013 - 05/2012)
4.	Liu, Chao: 2 articles (01/2013 - 05/2012)
5.	Catai, Jonatan R: 2 articles (08/2005 - 03/2004)
6.	Ahmad, Aftab: 1 article (01/2020)
7.	Ahmad, Shama: 1 article (01/2020)
8.	Crowe, David R: 1 article (01/2020)
9.	Husain, Maroof: 1 article (01/2020)
10.	Mariappan, Nithya: 1 article (01/2020)

Related Diseases

1.	Infections 01/01/2012 - "To this end, we have developed a production strategy based on using 211B cells (expressing Ad5 fiber) during amplification steps, while Ad5/40S infectivity is further improved by adding polybrene during infections. " 01/01/2018 - "Therefore, the present study aimed to elucidate the mechanism of this phenomenon as well as to develop an effective approach to overcome the negative impact of polybrene on the properties of human endometrium-derived mesenchymal stem cells (hMESCs) during lentiviral infection. " 09/01/2018 - "Our results showed that the efficiency of gene transduction by MSCV infection was enhanced following the concentration of polybrene and the energy of USWF. " 12/01/2014 - "Finally, transduction of HEK-293T, CHO, HepG2, MCF-7, MEFs and Jurkat cell lines was carried out with indicated cell numbers and multiplicities of infections of the vector in the presence of polybrene. " 01/01/2013 - "The transfect conditions such as the concentration of the virus, polybrene, transfect volume and media, multiplicity of infection (MOI) values, incubating time and centrifugation in 12-well plate at 200 x g were tested to obtain optimal transfect conditions. "
2.	Neoplasms (Cancer) 09/01/1991 - "Some drugs stimulate pituitary cell proliferation leading to hyperplasia and tumor formation; other chemicals have an inhibitory effect on adenohypophysial cells; and only one drug, hexadimethrine bromide, has been found to induce pituitary necrosis. " 02/01/2001 - "Furthermore, 293T/G/GP/LacZ could efficiently transduce human cancer cells regardless of the presence of chemical additives, whereas in other retroviruses, cationic chemical additives such as polybrene or liposomes were essential during virus infection. " 09/01/1999 - "Similar results were obtained using primary tumor cell cultures, where beta-gal expression was increased 1.5- to 10.7-fold (mean = 3.6) by polybrene, 1.8- to 7.5-fold (mean = 3.4) by DOTAP, and 2.3- to 10.4-fold (mean = 4.8) by protamine sulfate. " 01/01/1989 - "Two methods of DNA-mediated gene-transfer, namely, CaPO4 co-precipitation and polybrene/DMSO-induction were used to analyse oncogenes from various cancer cell-lines. " 01/01/2017 - "Moreover, combining VSV with ruxolitinib and Polybrene or DEAE-dextran successfully broke the resistance of HPAF-II cells to VSV by simultaneously improving VSV attachment and replication.IMPORTANCE Oncolytic virus (OV) therapy is an anticancer approach that uses viruses that selectively infect and kill cancer cells. "
3.	Lung Injury 01/01/2020 - "Treatment with hexadimethrine bromide (HDMBr; 10 mg/kg), an eNA neutralizing agent, 2 h post-exposure, reduced lung injury, inhibited disruption of alveolar-capillary barrier, improved blood oxygenation (PaO2/FiO2 ratio), thus reversing ARDS symptoms. " 05/01/1987 - "In addition, we found that anionic substances, heparin and albumin, blocked the lung injury induced by protamine, whereas other polycations, polylysine and hexadimethrine bromide, caused pulmonary vasoconstriction and increased vascular permeability similar to protamine. " 06/01/1989 - "In another series of experiments we tested the pretreatment inhibition potential of chlorpheniramine (an H1 receptor antagonist), dibutyryl-cyclic AMP (db-cAMP), and the calcium channel antagonists verapamil and nifedipine on polybrene-induced lung injury. "
4.	Necrosis 12/14/1966 - "Electron microscopie study of anterior pituitary necrosis caused by hexadimethrine bromide in rats." 07/23/2015 - "The results showed that polybrene at 0.1 μg/mL was safe to cochlear cells, and 0.5-10 μg/mL concentration induced hair cell necrosis in a dose-dependent manner. " 07/23/2015 - "Polybrene: Observations on cochlear hair cell necrosis and minimal lentiviral transduction of cochlear hair cells." 07/01/1972 - "[Hypophyseal necrosis induced by intrasellar injection of hexadimethrine bromide]." 06/01/1969 - "The excretion of renal cells following necrosis of the distal segment of the nephron by hexadimethrine bromide."
5.	Central Nervous System Infections (Central Nervous System Infection) 05/01/1996 - "This study was aimed at improving CNS infection by varying the stage of injection, viral envelope subgroup, viral titer, and the presence or absence of a transgene and/or the polycation polybrene in the inoculum. "

Related Drugs and Biologics

1.	Rituximab (Mabthera)
2.	Trastuzumab (Herceptin)
3.	Cetuximab (Erbitux)
4.	Bevacizumab (Avastin)
5.	Protamines (Protamine Sulfate)
6.	Heparin (Liquaemin)
7.	Hexadimethrine Bromide
8.	Dimethyl Sulfoxide (DMSO)
9.	DNA (Deoxyribonucleic Acid)
10.	DEAE-Dextran (Pulsar)

Related Therapies and Procedures

1.	Therapeutics
2.	Intra-Arterial Injections
3.	Injections
4.	Extracorporeal Circulation