Heterochromatin

10/01/2021 - "This study reveals a novel pathway that heterochromatin dysregulation induces translocation of nuclear materials into cytoplasm, which is important for inflammatory diseases and cancer."
01/01/1986 - "Constitutive heterochromatin studies in patients with solid tumors."
08/01/1982 - "In the present study, we have re-examined the role of the diploid chromosomes 4 in the suppression of malignancy using natural polymorphisms of the centromeric heterochromatin to identify the parental origin of the chromosomes 4 in the hybrid cells. "
12/01/1981 - "Constitutive heterochromatin (C-banding) studies in patients with testicular malignancies."
11/01/2023 - "Sustained DDR activation and heterochromatin changes further promote senescence-associated secretory phenotype (SASP), which is responsible for aging-related diseases and cancer development. "

02/01/2023 - "The core heterochromatin-related genes of breast cancer were identified by utilizing prognostic survival analysis and multivariate Cox hazard proportional regression analysis. "
01/01/2021 - "Together, these results uncover a critical function of TRPS1 in driving heterochromatin origin firing and breast cancer genome evolution."
11/01/2020 - "TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton in Breast Cancer."
04/01/2015 - "Here we show that breast tumors and cell lines frequently display major epigenetic instability of the inactive X chromosome, with highly abnormal 3D nuclear organization and global perturbations of heterochromatin, including gain of euchromatic marks and aberrant distributions of repressive marks such as H3K27me3 and promoter DNA methylation. "
04/01/2015 - "In conclusion, we observed epigenetic alterations (global genome hypomethylation, global hypoacetylation and accumulation of pericentric heterochromatin) in metastatic breast cancer cells of the 21 T series. "

12/01/1994 - "Clustering of terminal deletions in the long arms of X chromosomes, which are entirely occupied by heterochromatin, suggests that chromosomal repair mechanisms responsible for rejoining of chromosomal breaks are less effective in heterochromatic than in other genomic regions."
11/01/2023 - "The large-fragment deletions were enriched in the heterochromatin region and probably derived from chromosome breaks. "
01/01/2023 - "Dicentric chromosome breakage in Drosophila melanogaster is influenced by pericentric heterochromatin and occurs in nonconserved hotspots."
11/02/2021 - "We demonstrate that Polζ/REV3L ensures progression of replication forks through difficult-to-replicate pericentromeric heterochromatin, thereby preventing spontaneous chromosome break formation. "
08/01/2002 - "Then we monitored appearance of micronuclei during the passages since they are indicative of heterochromatin decondensation or chromosome breakage. "

01/01/1989 - "The C-band heterochromatin polymorphism of chromosomes 1, 9, and 16 was studied in lymphocytes from 53 patients with Ph1-positive chronic myeloid leukemia (CML) and 183 control persons. "
07/01/1987 - "The heteromorphism of constitutive heterochromatin in chromosomes #1, #9, and #16 was investigated in 44 chronic myelocytic leukemia patients and 44 controls using bone marrow and peripheral blood lymphocyte cultures. "
12/01/1986 - "Role of heterochromatin during preferential 9q;22q translocation in chronic myelogenous leukemia."
04/01/2006 - "While the major epigenetic heterochromatin factor, histone H3 methylated at lysine 9, is present in all cell types, its main counterparts, nonhistone proteins, heterochromatin proteins 1 (HP1) alpha, beta, and gamma, are dramatically reduced in peripheral blood leukocytes of normal donors and chronic myeloid leukemia patients, but are substantially increased in the blood of accelerated phase and blast crisis patients. "

08/03/2011 - "In plants, they regulate gene expression and heterochromatin assembly, and control protection against virus infection. "
05/01/2012 - "Association of the interferon-β gene with pericentromeric heterochromatin is dynamically regulated during virus infection through a YY1-dependent mechanism."
01/01/2017 - "We examined the change in methylation of two histone proteins, H3 and H4, which are major markers of heterochromatin, during the course of viral infection. "