Herpes Labialis (Fever Blister)

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228 relevant articles (35 outcomes, 50 trials/studies) found for this Disease

Description: Herpes simplex, caused by type 1 virus, primarily spread by oral secretions and usually occurring as a concomitant of fever. It may also develop in the absence of fever or prior illness. It commonly involves the facial region, especially the lips and the nares. (Dorland, 27th ed.)

Also Known As:

Fever Blister; Cold Sores; Cold Sore; Blister, Fever; Blisters, Fever; Fever Blisters; Labial Herpes Simplex; Sore, Cold; Sores, Cold; Herpes Simplex, Labial

Relationship Network

Disease Context: Research Results

Virus Diseases: 1311

DNA Virus Infections: 22

Herpesviridae Infections: 344

Herpes Simplex: 2404

Herpes Labialis: 228

Viral Skin Diseases: 10

Herpes Simplex: 2404

Herpes Labialis: 228

Stomatognathic Diseases: 250

Mouth Diseases: 55

Lip Diseases: 2

Herpes Labialis: 228

Skin and Connective Tissue Diseases

Skin Diseases: 5943

Infectious Skin Diseases: 10

Viral Skin Diseases: 10

Herpes Simplex: 2404

Herpes Labialis: 228

Related Diseases

1.	Herpes Labialis (Fever Blister)
2.	Infection
3.	Herpes Genitalis (Genital Herpes)
4.	Herpes Simplex
5.	Herpes Zoster

Experts

1.	Spruance, Spotswood L: 6 articles (08/2006 - 09/2002)
2.	Goodman, J J: 2 articles (11/2008 - 01/2000)
3.	Spruance, Spotswood: 2 articles (09/2006 - 04/2003)
4.	Hamed, Kamal: 2 articles (09/2006 - 07/2006)
5.	Gombos, F: 2 articles (08/2005 - 01/2001)
6.	Femiano, F: 2 articles (08/2005 - 01/2001)
7.	Scully, C: 2 articles (08/2005 - 01/2001)
8.	Hill, Joanne: 2 articles (05/2004 - 03/2003)
9.	Spruance, S L: 2 articles (06/2002 - 09/2001)
10.	Drouault, Y: 1 article (11/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Herpes Labialis:

1.	Acyclovir (Aciclovir)FDA LinkGeneric 04/13/1996 - "Topical acyclovir is beneficial in recurrent herpes labialis." 08/15/2006 - "CONCLUSIONS: Single-dose topical iontophoresis of acyclovir appears to be a convenient and effective treatment for cold sores and merits further clinical investigation." 05/28/1983 - "Acyclovir cream is well tolerated and effective for the treatment of recurrent herpes labialis." 06/01/1999 - "This pilot study suggests the improved clinical efficacy of the new liposomal preparation in comparison with Zovirax cream in the treatment of recurrent herpes labialis." 01/01/1993 - "The results of these trials showed that prophylactic topical acyclovir was mostly ineffective, but that prophylactic peroral acyclovir, in doses ranging from 400 to 1,000 mg/day, reduced the frequency of herpes labialis during treatment by 50-78%" Order ALL the reference details at left...
2.	valacyclovir (valaciclovir)FDA LinkGeneric 03/01/2003 - "Two identical, randomized, double-blind, parallel-group studies were conducted to evaluate the efficacy of oral valacyclovir 500 mg (n=49) versus placebo (n=49) once daily for 16 weeks in the suppression of herpes labialis among patients with a history of 4 or more recurrent lesions in the previous year" 03/01/2003 - "These studies provide evidence supporting a simple, 1-day valacyclovir treatment regimen for cold sores that is safe and effective" 03/01/2003 - "The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported" 09/01/2004 - "METHODS: The authors enrolled 125 otherwise healthy HSV-seropositive adults who reported having recurrent herpes labialis (more than one episode per year and at least one episode in the previous year) in a randomized, double-blind, placebo-controlled study and gave them valacyclovir prophylactically (2 grams taken twice on the day of dental treatment and 1 g taken twice the next day) or a matching placebo" 09/01/2004 - "This study determined the efficacy and safety of oral valacyclovir in suppressing dentally related cold sore outbreak and HSV shedding" Order ALL the reference details at left...
3.	famciclovir (Famvir)FDA LinkGeneric 09/01/2006 - "CONCLUSIONS: Single-dose famciclovir appears to be an effective, convenient therapy for recurrent herpes labialis" 07/01/2006 - "Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis." 09/01/2006 - "Single-dose famciclovir for the treatment of herpes labialis." 07/01/2006 - "CONCLUSION: Single-dose famciclovir reduced time to healing of herpes labialis lesions by approximately 2 days compared with placebo." 07/01/2006 - "METHODS: In all, 701 randomly assigned patients self-initiated therapy with famciclovir (1500 mg once [single dose] or 750 mg twice a day for 1 day [single day]) or placebo within 1 hour of onset of the prodromal symptoms of an episode of herpes labialis" Order ALL the reference details at left...
4.	penciclovir (Denavir)FDA Link 01/01/2000 - "OBJECTIVE: The purpose of this study was to further define the therapeutic value of penciclovir cream in the treatment of sunlight-induced herpes labialis by comparing its efficacy and tolerability with those of an inactive control (purified water)" 01/01/2000 - "Penciclovir Cream Herpes Labialis Study Group." 04/15/2003 - "Subjects received topical penciclovir for 4 days during successive episodes of recurrent herpes labialis" 04/15/2003 - "Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialis." 09/01/2002 - "Penciclovir susceptibilities of herpes simplex virus isolates from patients using penciclovir cream for treatment of recurrent herpes labialis." Order ALL the reference details at left...
5.	docosanol FDA Link 11/01/1996 - "To demonstrate the efficacy of n-docosanol 10% cream in the treatment of recurrent herpes labialis, a randomised, double-blind, parallel group, placebo-controlled study was undertaken in 63 patients" 11/01/1996 - "n-Docosanol 10% cream in the treatment of recurrent herpes labialis: a randomised, double-blind, placebo-controlled study." 12/01/2004 - "Docosanol is the first topical antiviral approved for over-the-counter use in recurrent herpes labialis." 12/01/2004 - "Docosanol: a topical antiviral for herpes labialis." 09/01/2002 - "N-docosanol (Abreva) for herpes labialis: problems and questions." Order ALL the reference details at left...
6.	Antiviral Agents (Antivirals)IBA 08/01/1991 - "This model can be employed in the evaluation of topical antiviral agents for herpes labialis in a healthy population, because it standardizes criteria for subject enrollment and provides objective and reproducible measurements of therapeutic efficacy." 04/01/1994 - "Models of UV radiation induced herpes labialis utilizing crude light sources have previously been used to examine the efficacy of antivirals" 03/01/2007 - "For years, I was plagued by cold sores and took antiviral drugs to treat the outbreaks" 04/01/2004 - "DATA SYNTHESIS: We reviewed 5 placebo-controlled and 2 comparative studies evaluating oral antivirals for acute treatment of recurrent herpes labialis" 04/01/2004 - "OBJECTIVE: To evaluate the use and benefit of oral antivirals in the acute treatment of episodic, recurrent herpes labialis" Order ALL the reference details at left...
7.	Levamisole (Decaris)FDA Link 01/01/1981 - "Levamisole - a new treatment for two old problems: recurrent aphthous ulceration and recurrent labial herpes simplex]" 05/01/1978 - "A double-blind, controlled trial of levamisole in the prevention and treatment of recurrent cold sores was performed" 05/01/1978 - "A double-blind, controlled trial of levamisole in the treatment of recurrent herpes labialis." 11/01/1979 - "Clinical evaluation of the use of levamisole in treatment of recurrent labial herpes simplex]" 08/08/1974 - "Letter: Levamisole for recurrent herpes labialis." Order ALL the reference details at left...
8.	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 09/01/1983 - "The efficacy of topical acyclovir in the treatment of herpes labialis has been evaluated in placebo-controlled trials with both the polyethylene glycol ointment and modified aqueous cream base preparations" 05/01/1984 - "Topical acyclovir in polyethylene glycol was ineffective for the treatment of herpes labialis despite an optimum therapeutic opportunity." Order ALL the reference details at left...
9.	ZincIBA 08/01/2005 - "Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy." 08/01/2005 - "BACKGROUND: The objective of this study was to investigate the effect of zinc on recurrent herpes labialis" 08/01/2005 - "CONCLUSIONS: Systemic zinc sulphate appeared to reduce both the number of episodes and the time to recovery of herpes labialis." 08/01/2005 - "MATERIALS/METHODS: Twenty patients (12 females; median age 26.6 years) with a history of recurrent herpes labialis >6 episodes each year were treated with systemic zinc sulphate 22.5 mg twice daily for the months of February, March, September and October" Order ALL the reference details at left...
10.	Tetracaine (Amethocaine)FDA LinkGeneric 12/01/1999 - "OBJECTIVE: The purpose of this study was to determine whether a topical preparation of a tetracaine cream is safe and effective in the treatment of recurrent herpes labialis in immunocompetent patients" 12/01/1999 - "METHODS: A double-blind, placebo-controlled study was conducted to assess the relative effectiveness and safety of 1.8% tetracaine equivalent in a cream base versus placebo in the treatment of herpes labialis in immunocompetent adults" 12/01/1999 - "A double-blind, placebo-controlled study of topical tetracaine in the treatment of herpes labialis." 12/01/1999 - "CONCLUSION: Our findings indicate that a 1.8% topical tetracaine cream, when applied frequently, significantly reduces the healing time of recurrent herpes labialis lesions" 12/01/1999 - "Local anesthetics, such as tetracaine, have been used in over-the-counter topical products, but are only labeled for the relief of pain and itching associated with cold sores and fever blisters" Order ALL the reference details at left...

Therapies and Procedures

1.	Lasers (Laser) 09/01/2006 - "BACKGROUND: Previous research demonstrated that 1072-nm narrowband laser light is effective in the treatment of cold sores" 12/01/1988 - "It was the purpose of this study to assess soft laser treatment of hypersensitive dentin, gingivitis, pulp-capped teeth, herpes labialis, and nausea" Order ALL the reference details at left...
2.	Ambulatory Care (Outpatient Care) 02/17/2004 - "Trials of cold sore remedies, for example, often require daily clinic visits during outbreaks, imposing substantial burden on participants" Order ALL the reference details at left...
3.	Cesarean Section (Caesarean Section) 09/01/2005 - "In terms of the patient's case history, she had a Cesarean section four months before, herpes labialis 30 days before, varicella zoster 20 days before" 11/01/1995 - "The herpes labialis lesion was still present and urgent Caesarean section was begun using subarachnoid 0.75% bupivacaine 1.5 ml. The patient had no intraoperative problems and a 1700-g healthy male child was delivered." 08/01/1990 - "Herpes labialis in parturients receiving epidural morphine following cesarean section." Order ALL the reference details at left...
4.	Oral Hygiene (Dental Hygiene) 11/01/1977 - "A retrospective 12-year investigation of 1,788 professional school students from the schools of medicine, veterinary medicine, dental medicine, nursing, and dental hygiene was conducted by the mailed distribution of questionnaires requesting information on current and prior disease history of recurrent herpes labialis (RHL)" 09/01/2007 - "Dental and dental hygiene students frequently interact with patients with herpes simplex virus (HSV) infections, often simply referred to as cold sores" Order ALL the reference details at left...
5.	Drug Therapy (Chemotherapy) 03/01/1999 - "The company also sells a cream used for herpes cold sores and is developing an intravenous treatment for immunocompromised individuals, including those who have had chemotherapy for cancer." 09/01/1996 - "Herpes labialis frequently occurs, may be confused with chemotherapy-induced stomatitis, and it requires appropriate treatment and secondary prophylaxis once recognized" Order ALL the reference details at left...

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