Pemphigoid Gestationis (Herpes Gestationis)

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176 relevant articles (4 outcomes, 14 trials/studies) found for this Disease

Description: An itching, autoimmune, bullous SKIN disease that occurs during the last two trimesters of PREGNANCY and PUERPERIUM. It also affects non-pregnant females with tissue of PLACENTA origin, such as CHORIOCARCINOMA; or HYDATIDIFORM MOLE. It exhibits antigenic and clinical similarity to bullous pemphigoid (PEMPHIGOID, BULLOUS). This disease does not involve herpes viruses (old name, herpes gestationis).

Also Known As:

Herpes Gestationis; Gestationi, Pemphigoid; Gestationis, Pemphigoid; Pemphigoid Gestationi

Relationship Network

Disease Context: Research Results

Female Urogenital Diseases and Pregnancy Complications

Pregnancy Complications: 552

Pemphigoid Gestationis: 176

Skin and Connective Tissue Diseases

Skin Diseases: 6187

Vesiculobullous Skin Diseases: 223

Pemphigoid Gestationis: 176

Related Diseases

1.	Bullous Pemphigoid (Pemphigoid)
2.	Dermatitis Herpetiformis (Disease, Duhring's)
3.	Pemphigus (Pemphigus Vulgaris)
4.	Skin Diseases
5.	Porphyrias

Experts

1.	Zillikens, Detlef: 3 articles (04/2006 - 01/2002)
2.	De Pità, O: 2 articles (08/2007 - 06/2003)
3.	Sitaru, Cassian: 2 articles (04/2006 - 01/2002)
4.	Wojnarowska, F: 2 articles (08/2003 - 11/2001)
5.	Berti, S: 2 articles (06/2003 - 09/2002)
6.	Amato, L: 2 articles (06/2003 - 09/2002)
7.	Fabbri, P: 2 articles (06/2003 - 09/2002)
8.	Ilves, Mika: 1 article (04/2008)
9.	Bruckner-Tuderman, Leena: 1 article (04/2008)
10.	Autio-Harmainen, Helena: 1 article (04/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pemphigoid Gestationis:

1.	Immunoglobulin A (IgA)IBA 06/01/1989 - "Placentae from seven patients with pemphigoid gestationis (PG) and two patients with linear IgA disease were studied. " 06/01/1989 - "Immunopathology of the placenta in pemphigoid gestationis and linear IgA disease." 12/01/2004 - "NC16A domain-specific T cells have been identified in the blood of individuals with bullous pemphigoid (BP), pemphigoid gestationis and linear IgA disease, but there are no data investigating the potential role for such T cells in the pathogenesis of MMP. " 03/01/1988 - "Palmo-plantar involvement in auto-immune blistering disorders--pemphigoid, linear IgA disease and herpes gestationis." 01/01/2008 - "The pemphigoid group of autoimmune blistering diseases includes distinct entities (bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, linear IgA dermatosis and lichen planus pemphigoides) that are characterized by relatively consistent clinical, histologic and immunopathologic findings. " Order ALL the reference details at left...
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2004 - "We present the clinical case of a 38 year-old woman to whom a case of Herpes Gestationis was diagnosed when she was 15 weeks pregnant and whom has been treated with corticosteroids and antihistamine's showing positive results and without major complications for the mother or the embryo. " 12/01/2008 - "[Topical or systemic corticosteroids in patients with pemphigoid gestationis and polymorphic eruption of pregnancy]" 11/01/2004 - "Moreover, we underline the efficiency of topical class I corticosteroids in the treatment of pemphigoid gestationis." 05/01/2001 - "DISCUSSION: Severe form of pemphigoid gestationis are currently treated with 0.5 to 1 mg/kg/day of systemic corticosteroids, with maternal and pediatric possible side effects. " 01/01/1998 - "[Herpes gestationis--oral corticosteroids cannot be avoided]" Order ALL the reference details at left...
3.	Ritodrine (Yutopar)FDA Link 11/01/1984 - "Ritodrine therapy associated with remission of pemphigoid gestationis." 05/01/1988 - "Herpes gestationis and ritodrine." 01/01/1986 - "Ritodrine and pyridoxine in herpes gestationis." Order ALL the reference details at left...
4.	rituximab (Mabthera)FDA Link 08/01/2007 - "Severe persistent pemphigoid gestationis: long-term remission with rituximab." Order ALL the reference details at left...
5.	AntigensIBA 01/01/1988 - "Abnormal expression of class II MHC antigens was consistently observed in an immunohistological study on placentae from patients with pemphigoid gestationis. " 07/01/1994 - "We report a severe case of pemphigoid gestationis (PG) with an unusual target antigen. " 07/01/1994 - "Severe case of pemphigoid gestationis with unusual target antigen." 01/01/1992 - "The heterogeneity of immunofluorescence patterns may correspond to the heterogeneity of antigen recognition by different patients with pemphigoid gestationis." 01/01/1992 - "Pemphigoid gestationis-related antigen is expressed by isolated basal keratinocytes and is resistant to trypsinization. " Order ALL the reference details at left...
6.	Complement System Proteins (Complement)IBA 01/01/1978 - "Herpes gestationis: studies on the binding characteristics, activity and pathogenetic significance of the complement-fixing factor." 07/01/1973 - "This study provides suggestive evidence that activation of complement is occurring via the alternate pathway in herpes gestationis. " 10/01/1993 - "Complement polymorphism in herpes gestationis: association with C4 null allele." 05/01/1989 - "Tissue damage in pemphigoid gestationis is apparently mediated by complement fixation which is detected via the classical complement cascade." 08/01/1987 - "The results demonstrated that the complement fixation antibody (herpes gestationis factor) could bind to the basement membrane zone of skin, amnion and chorion laeve but not to that of the placental syncytiotrophoblast. " Order ALL the reference details at left...
7.	AntibodiesIBA 04/01/1996 - "We examined 42 herpes gestationis sera with immunofluorescence of normal human skin sections, and found that anti-keratinocyte cell surface antibodies were detected specifically in 10 herpes gestationis sera. " 04/01/1996 - "Specific detection of anti-cell surface antibodies in herpes gestationis sera." 11/01/1983 - "It has been suggested that anti-HLA antibodies might be involved in the pathogenesis of herpes gestationis (HG). " 01/01/1980 - "[Herpes gestationis: antibasal cell antibodies in five out of sixteen cases (author's transl)]" 02/01/1980 - "Bullous pemphigoid, herpes gestationis and linear dermatitis herpetiformis: circulating anti-basement membrane zone antibodies; in vitro studies." Order ALL the reference details at left...
8.	Immunoglobulin G (IgG)IBA 10/01/1991 - "Our study indicates that in herpes gestationis the cleavage, accompanied by IgG, C3 and immunocomplex deposition, occurs at the level of the sub-basal dense plate. " 02/01/1997 - "We describe a case of clinically typical pemphigoid gestationis with the combination of intercellular IgG and BMZ IgG and C3 staining on immunofluorescence, a pattern which is unique for this condition." 05/01/1989 - "IgG1 was found to be the major IgG subclass in both serum and tissue, being detected in the sera of all pemphigoid gestationis patients studied. " 05/01/1989 - "The distribution of IgG subclasses in pemphigoid gestationis: PG factor is an IgG1 autoantibody." 06/01/1985 - "Indirect immunofluorescence can be used to demonstrate the so-called herpes gestationis factor (HGF), a heat stable immunoglobulin G (IgG), in the maternal and foetal blood. " Order ALL the reference details at left...
9.	AutoantibodiesIBA 04/15/1999 - "Autoantibodies associated with herpes gestationis (HG), a pregnancy-associated autoimmune skin disease, target the hemidesmosomal protein BP180. " 09/01/1995 - "BP180 is a 180kDa hemidesmosomal protein recognized by bullous pemphigoid (BP) and pemphigoid gestationis (PG) autoantibodies. " 06/01/1994 - "Autoantibodies associated with the subepidermal blistering disorders bullous pemphigoid and herpes gestationis react with a 180-kD transmembrane hemidesmosomal protein, designated BP180. " 06/01/1994 - "Development of an ELISA to detect anti-BP180 autoantibodies in bullous pemphigoid and herpes gestationis." 11/15/1993 - "Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain." Order ALL the reference details at left...
10.	Complementary DNA (cDNA)IBA 08/01/1996 - "To confirm these previous results by a large-scale study, we examined serum from 154 bullous pemphigoid and 43 herpes gestationis patients using an immunoblot technique with the BP180 NC16a domain fusion protein, which had been prepared using cDNA obtained from a human keratinocyte cDNA library by polymerase chain reaction amplification. " 10/01/1990 - "Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. " Order ALL the reference details at left...

Therapies and Procedures

1.	Cesarean Section (Caesarean Section) 10/01/1998 - "The authors report an original case of large cutaneous necrosis of the abdominal wall following a first cesarean section in a patient with a background of pemphigoid gestationis. " 05/01/1996 - "Seven days after emergency Caesarean section for pre-eclampsia, she developed a pruritic blistering eruption which clinically resembled pemphigoid gestationis. " Order ALL the reference details at left...
2.	Intensive Care (Surgical Intensive Care) 01/01/1984 - "In view of this it is essential that patients with pemphigoid gestationis are delivered in maternity units which have facilities for intensive care of the newborn." Order ALL the reference details at left...
3.	Epidural Analgesia 09/01/1990 - "A 23-yr-old parturient with herpes gestationis spontaneously delivered a normal healthy infant under epidural analgesia. " 09/01/1990 - "Epidural analgesia for a parturient with herpes gestationis." Order ALL the reference details at left...
4.	Plasma Exchange 10/18/1980 - "Plasma exchange in herpes gestationis." Order ALL the reference details at left...
5.	Ovariectomy (Oophorectomy) 11/01/1992 - "Pemphigoid gestationis--response to chemical oophorectomy with goserelin." Order ALL the reference details at left...

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