Herpangina

Acute types of coxsackievirus infections or ECHOVIRUS INFECTIONS that usually affect children during the summer and are characterized by vesiculoulcerative lesions on the MUCOUS MEMBRANES of the THROAT; DYSPHAGIA; VOMITING, and FEVER.

Also Known As:

Networked: 27 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Foot and Mouth Disease Hand (Hand, Foot, Mouth Disease)
2.	Infections
3.	Herpes Zoster
4.	Herpes Simplex
5.	Splenomegaly

Experts

1.	Chen, Yan: 2 articles (06/2021 - 07/2020)
2.	Dai, Meng-Yuan: 1 article (09/2021)
3.	Fei, Yu-Tong: 1 article (09/2021)
4.	Hu, Xiao-Yang: 1 article (09/2021)
5.	Li, Yi-Lin: 1 article (09/2021)
6.	Liang, Shi-Bing: 1 article (09/2021)
7.	Liu, Jian-Ping: 1 article (09/2021)
8.	Moore, Michael: 1 article (09/2021)
9.	Xia, Ru-Yu: 1 article (09/2021)
10.	Zhang, Ying-Ying: 1 article (09/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Herpangina:

1.	Neutralizing AntibodiesIBA 02/27/2014 - "An anti-EV71 neutralizing antibody titer of 1:16 was associated with protection against EV71-associated hand, foot, and mouth disease or herpangina. " 11/01/1952 - "Studies in man of neutralizing antibodies against group A Coxsackie (herpangina) viruses; prevalence of antibodies in a community in 1949 and 1950."
2.	tanreqingIBA 01/01/2020 - "In this study, we performed a network meta-analysis to investigate the efficacy of CHIs, including Reduning injection (RDN), Shuanghuanglian injection (SHL), Tanreqing injection (TRQ), Xiyanping injection (XYP), and Yanhuning injection (YHN), in the treatment of herpangina. "
3.	reduningIBA 01/01/2020 - "In this study, we performed a network meta-analysis to investigate the efficacy of CHIs, including Reduning injection (RDN), Shuanghuanglian injection (SHL), Tanreqing injection (TRQ), Xiyanping injection (XYP), and Yanhuning injection (YHN), in the treatment of herpangina. "
4.	yanhuningIBA 01/01/2020 - "In this study, we performed a network meta-analysis to investigate the efficacy of CHIs, including Reduning injection (RDN), Shuanghuanglian injection (SHL), Tanreqing injection (TRQ), Xiyanping injection (XYP), and Yanhuning injection (YHN), in the treatment of herpangina. "
5.	VaccinesIBA 02/27/2014 - "The EV71 vaccine provided protection against EV71-associated hand, foot, and mouth disease or herpangina in infants and young children. " 02/27/2014 - "The vaccine efficacy against EV71-associated hand, foot, and mouth disease or herpangina was 94.8% (95% confidence interval [CI], 87.2 to 97.9; P<0.001) in this cohort. " 11/08/2018 - "Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development." 01/01/2018 - "Coxsackievirus A10 (CVA10) recently emerged as a major pathogen of hand, foot, and mouth disease and herpangina in children worldwide, and lack of a vaccine or a cure against CVA10 infections has made therapeutic antibody identification a public health priority. "
6.	Ribavirin (Virazole)FDA LinkGeneric 01/01/2020 - "CHIs were found to be superior to ribavirin in terms of treatment performance and may be beneficial for patients with herpangina. " 06/01/2009 - "[Therapeutic effect of ribavirin aerosol on herpangina in children]."
7.	InterferonsIBA 06/01/2021 - "Local application of recombinant interferon α-2b spray showed better efficacy for acute herpangina in children. " 06/01/2021 - "Efficacy and safety of interferon α-2b spray for herpangina in children: A randomized, controlled trial." 01/01/2021 - "EV-A71 infection induced interferon, pro-inflammatory cytokines and chemokines, including IFN-β, IL-6, CCL5, and TNF-α in tonsillar epithelial cells, which may play a critical role in EV-A71-caused herpangina. "
8.	Antiviral Agents (Antivirals)IBA 01/01/2020 - "Considering the limitations of broad-spectrum antiviral drugs for the treatment of herpangina and the extensive exploration of Chinese herbal injections (CHIs), systematic evaluation of the efficacy of different CHIs in the treatment of herpangina is a key imperative. " 10/01/1972 - "[Treatment of viral lesions--herpes simplex, herpes zoster and herpangina--with the antiviral agent isoprinosine]."
9.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2018 - "The present study indicates that higher serum level of CRP is strongly associated with pediatricians prescribing antibiotics for children experiencing herpangina or HFMD. " 12/01/1990 - "Symptoms and signs of the common cold, influenza or croup, the occurrence of conjunctivitis in some adenoviral infections, generalised lymphadenopathy and splenomegaly in glandular fever or the presence of vesicles characteristic of herpangina (Coxsackie A virus) or of herpes simplex infection, occasionally enable a clinical diagnosis and avoid the need for antibiotic therapy. " 08/28/2023 - "Being =6 years was significantly associated with fever, mucosal pathology, mucosal infection, and herpangina, and being >6 years was associated with pain, previous antibiotic treatment and at discharge, and previous NSAID regimen. "
10.	AntibodiesIBA 04/01/2012 - "Herpangina occurred in 64% of children with EV71 seropositivity and 48% of those without EV71 antibodies (p = 0.12). " 11/01/1952 - "Studies in man of neutralizing antibodies against group A Coxsackie (herpangina) viruses; prevalence of antibodies in a community in 1949 and 1950."

Therapies and Procedures

1.	Injections 01/01/2020 - "Comparative Efficacy of Chinese Herbal Injections for the Treatment of Herpangina: A Bayesian Network Meta-Analysis of Randomized Controlled Trials." 01/01/2020 - "Considering the limitations of broad-spectrum antiviral drugs for the treatment of herpangina and the extensive exploration of Chinese herbal injections (CHIs), systematic evaluation of the efficacy of different CHIs in the treatment of herpangina is a key imperative. "
2.	Therapeutics 12/01/1990 - "Symptoms and signs of the common cold, influenza or croup, the occurrence of conjunctivitis in some adenoviral infections, generalised lymphadenopathy and splenomegaly in glandular fever or the presence of vesicles characteristic of herpangina (Coxsackie A virus) or of herpes simplex infection, occasionally enable a clinical diagnosis and avoid the need for antibiotic therapy. "
3.	Chinese Traditional Medicine (Traditional Chinese Medicine) 08/01/2014 - "(Molluginaceae), a perennial subshrubs herb, grows at low altitudes in the southern part of Taiwan, and is used in traditional Chinese medicine for herpes zoster and herpangina. "
4.	Ambulatory Care (Outpatient Care) 07/01/2010 - "A total of 242 pregnant women who had singleton births and who visited ambulatory care centers for the treatment of herpangina were assessed, together with 1936 matched women as a comparison group. "