|1.||Cocaine-Related Disorders (Cocaine Addiction)
|2.||Substance-Related Disorders (Drug Abuse)
|4.||Opioid-Related Disorders (Opiate Addiction)
|5.||Major Depressive Disorder (Major Depressive Disorders)
|1.||Kreek, Mary Jeanne: 14 articles (01/2016 - 02/2003)|
|2.||Davoli, M: 12 articles (01/2008 - 01/2002)|
|3.||Darke, Shane: 11 articles (06/2015 - 07/2004)|
|4.||Ross, Joanne: 11 articles (06/2015 - 07/2004)|
|5.||Teesson, Maree: 11 articles (06/2015 - 07/2004)|
|6.||Ott, Jurg: 9 articles (01/2016 - 01/2006)|
|7.||Maremmani, Icro: 9 articles (01/2016 - 01/2007)|
|8.||Zhou, Wenhua: 8 articles (09/2014 - 04/2011)|
|9.||Lintzeris, Nicholas: 8 articles (11/2013 - 02/2002)|
|10.||Wiesbeck, Gerhard A: 7 articles (05/2015 - 01/2011)|
|1.||Methadone (Dolophine)FDA LinkGeneric
07/01/2006 - "The results confirm that, in a nonexperimental clinical practice setting, BUP is as effective as methadone in the treatment of heroin dependence, with significantly better opiate abuse control, thus possibly allowing longer and more effective treatment programs with reduced relapse rates."
03/01/2010 - "Finally, L-, but not D,L-methadone seems to be more effective in reducing additional heroin abuse."
06/01/2008 - "Heat and pain thresholds were measured by quantitative sensory testing (QST) in 23 subjects with heroin dependence in full, sustained remission months after detoxification from methadone and 27 healthy non-drug using controls. "
07/15/2008 - "ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence."
03/01/2007 - "Methadone maintenance therapy has been the mainstay of treatment for heroin addiction since the 1970s. "
|2.||Buprenorphine (Subutex)FDA LinkGeneric
01/01/2014 - "Buprenorphine is an effective medication in the maintenance treatment of heroin dependence, retaining people in treatment at any dose above 2 mg, and suppressing illicit opioid use (at doses 16 mg or greater) based on placebo-controlled trials.However"
01/01/2002 - "Buprenorphine is an effective treatment for heroin dependence. "
08/01/1998 - "Buprenorphine maintenance is an effective treatment for heroin dependence in a primary care setting."
09/01/2014 - "Buprenorphine is a promising treatment for heroin addiction. "
12/01/1985 - "Buprenorphine as new treatment for heroin dependence."
12/01/2008 - "Retention and response rates were high, suggesting that heroin-assisted therapy is a safe and highly effective treatment for people with chronic heroin addiction."
05/10/2014 - "The results suggest that CET combined with BT treatment is effective in reducing craving and physiology reactivity in heroin dependents and could be used as a component of heroin-dependence rehabilitation."
04/20/2011 - "However, little is known whether it is also effective for the treatment of heroin dependence, in particular for relapse to heroin seeking. "
02/01/2015 - "Providing heroin to people with heroin addiction taking part in medical trials assessing the effectiveness of the drug as a treatment alternative breaches ethical research standards, some ethicists maintain. "
01/22/2015 - "However, few studies have focused on examining the variation in resting-state functional connectivity in heroin-dependent individuals, which might help further understanding the mechanisms underlying heroin addiction. "
|4.||Naltrexone (ReVia)FDA LinkGeneric
01/01/2007 - "There is on-going controversy in relation to the efficacy of naltrexone used for the treatment of heroin addiction, and the important covariates of that success. "
06/01/2004 - "Naltrexone may be more effective for treating opioid (heroin) dependence in Russia than in the U.S. "
07/15/2004 - "To investigate the efficacy of low doses of naltrexone in relapse prevention for heroin dependence. "
07/05/1999 - "Is naltrexone a cure for heroin dependence?"
02/01/2013 - "Assessing the usefulness of health data linkage in obtaining adverse event data in a randomised controlled trial of oral and implant naltrexone in the treatment of heroin dependence."
|5.||2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA
02/28/2015 - "After one year of MMT, the monetary cost of heroin addiction fell, both the productivity and mental health of the participants׳ improved, but limited gains were seen with regard to their QOL. "
01/01/2013 - "The levels of depressive symptoms, heroin dependence and QOL in all three groups improved after receiving MMT for 3 months and the improvement was maintained during the MMT period. "
02/28/2015 - "The aim of this study was to evaluate the changes in the monetary cost of heroin addiction and productivity after one year of MMT. "
03/01/2012 - "A trial of DBS is less expensive ($81,000) than untreated (or relapsed) heroin dependence ($100,000), but more expensive than MMT ($58,000). "
11/01/2014 - "Forty patients with heroin abuse history, who referred to Imam Reza Hospital for MMT were included. "
|6.||Cocaine (Cocaine HCl)IBA
01/01/2010 - "African-American men were recruited for this study: 577 patients with lifetime DSM-IV single and comorbid diagnoses of alcohol, cocaine, and heroin dependence, and 255 control subjects. "
01/01/2009 - "Ecological momentary assessment has greatly enhanced the study of tobacco addiction, but its use has rarely been attempted in individuals with cocaine or heroin addiction. "
11/01/2008 - "The authors compared performance of 48 HIV seropositive (HIV+) and 48 HIV seronegative (HIV-) participants with history of cocaine and/or heroin dependence across multiple Trial Blocks of three procedural learning (PL) tasks: Rotary Pursuit (RP), Mirror Star Tracing (MST), and Weather Prediction (WP). "
09/01/2008 - "In the CM group, BZD-U had significantly worse outcomes on in-treatment cocaine use, quality-of-life scores, needle-sharing behaviors, and current heroin dependence diagnoses at study exit compared to BZD-N. "
09/01/2008 - "Outcome measures were: urine drug screens (thrice weekly); quality of life and self-reported HIV-risk behaviors (every 2 weeks); and current DSM-IV diagnosis of cocaine and heroin dependence (study exit). "
|7.||Methadyl Acetate (LAAM)FDA Link
11/01/2003 - "This study demonstrates (a) the efficacy of LAAM as a treatment for heroin dependence, and (b) the capacity for LAAM to be effectively delivered in primary care settings by trained general practitioners and pharmacists. "
01/01/2003 - "Although LAAM is no longer considered a first line treatment for heroin addiction, these results demonstrate the feasibility of utilizing long-acting agonist therapies such as LAAM to treat opioid dependence among NEP attenders."
01/01/1976 - "The use of l-alpha-acetylmethadol in treatment of heroin addiction: an open study."
01/01/2005 - "Because prisoners with preincarceration heroin dependence typically relapse following release, a pilot study examined a novel opioid agonist maintenance program whereby consenting males initiated levo-alpha-acetylmethadol (LAAM) treatment shortly before release from prison with opportunity to continue maintenance in the community. "
04/01/2002 - "Incarcerated males with preincarceration heroin dependence were randomly assigned to Levo-alpha-acetylmethadol (LAAM) maintenance or control conditions 3 months before release. "
|8.||Fluoxetine (Prozac)FDA LinkGeneric
04/01/1992 - "Use of fluoxetine in heroin addiction."
01/01/2010 - "Naltrexone was superior to placebo and fluoxetine in the efficacy of maintenance of remission and preventing relapse in patients with heroin addiction. "
01/01/2010 - "[Naltrexone and fluoxetine for maintenance of remission in patients with heroin addiction: a double-blind randomized placebo-controlled trial]."
12/01/2006 - "This randomized placebo-controlled trial tested the efficacy of oral naltrexone with or without fluoxetine for preventing relapse to heroin addiction and for reducing HIV risk, psychiatric symptoms, and outcome. "
12/01/2006 - "Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, Russia."
|9.||Opioid Analgesics (Opioids)IBA
09/01/2000 - "Long-acting delta(2)-opioid antagonists may be beneficial in the treatment of heroin dependence or as adjuncts to reduce the abuse liability of opioid analgesics."
09/01/2012 - "These findings have direct relevance for understanding the impact of heroin addiction and the opioids used to treat addiction as well as on the potential interplay between opioid abuse and the immunological response to an infective agent."
01/01/2010 - "Psychopathological symptoms in patients with heroin addiction are generally considered to be part of the drug addict's personality, or else to be related to the presence of psychiatric comorbidity, raising doubts about whether patients with long-term abuse of opioids actually possess specific psychopathological dimensions. "
05/01/2004 - "Opioid dependence is generally considered synonymous with heroin dependence or dependence on prescribed opioid analgesics. "
07/01/2000 - "Vienna suffered an epidemic of heroin abuse in recent years, with drug-deaths due to opioids increasing from 62 in 1991 to 143 in 1993. "
|10.||Naloxone (Narcan)FDA LinkGeneric
01/01/2006 - "[A possibility of the use of low naloxone dosages in the treatment of heroin dependence]."
09/01/1968 - "Naloxone in heroin dependence."
12/01/2007 - "A randomized trial of effectiveness and cost-effectiveness of observed versus unobserved administration of buprenorphine-naloxone for heroin dependence."
09/01/2007 - "The following study, conducted in Puerto Rico, examined the feasibility of providing daily buprenorphine-naloxone (bup-nx) in prison and on release to 45 male inmates with histories of heroin addiction. "
06/01/2009 - "Methadone-naloxone in 50:1 ratio has the pharmacological properties to be a useful combination product for treatment of heroin addiction with reduced risk of injection."
|1.||Drug Therapy (Chemotherapy)
01/01/2003 - "[Pharmacotherapy in heroin addiction: pharmacological approaches to remission stabilization and recurrence prevention]."
07/01/2010 - "While long-term heroin addiction is associated with hypothalamus-pituitary-adrenal (HPA) axis dysregulation, few studies have used in vivo brain imaging to examine the impact on pituitary gland volume (PGV) or its relationship with substitution pharmacotherapy. "
08/01/2006 - "A total of 551 participants were randomized to treatment in three heroin-dependence treatment trials participating in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD) project. "
07/01/2006 - "These cases illustrate significant levels of dependence on a licit, and readily available, source of opiates requiring high doses of pharmacotherapy that match those typically required by individuals who are treated for heroin dependence."
08/23/2003 - "A growing number of effective pharmacotherapies are becoming available for the treatment of heroin addiction, although not all of those are available in the Netherlands. "
|2.||Opiate Substitution Treatment
04/01/2011 - "Opioid substitution therapy (OST) is the most commonly provided treatment for heroin dependence in Australia and has been shown to be effective. "
01/01/2009 - "Opioid substitution treatment (OST) is an effective treatment for heroin dependence. "
01/01/2015 - "Promoted globally as an evidence-based intervention in the prevention of HIV and treatment of heroin addiction among people who inject drugs (PWID), opioid substitution treatment (OST) can help control emerging HIV epidemics among PWID. "
01/01/2010 - "In most countries, methadone maintenance is the first widely used opioid replacement therapy to treat heroin dependence, and it remains the best-researched treatment for this problem. "
01/01/2009 - "Methadone maintenance was the first widely used opioid replacement therapy to treat heroin dependence, and it remains the best-researched treatment for this problem. "
10/15/2003 - "Safety of injectable opioid maintenance treatment for heroin dependence."
05/01/2010 - "Long-acting sustained release formulations of naltrexone (implantable and injectable) might help to improve compliance and, thus, increase the efficacy of abstinence-oriented treatment of heroin dependence with naltrexone. "
05/01/2002 - "The Swiss trials on medical prescription of injectable diacetylmorphine (pharmaceutical heroin) for "severe" heroin dependence provoked very controversial commentaries. "
11/01/2013 - "Injectable opioid treatments are more cost-effective than optimised oral methadone for chronic refractory heroin addiction. "
11/01/2013 - "Despite evidence of the effectiveness of injectable opioid treatment compared with oral methadone for chronic heroin addiction, the additional cost of injectable treatment is considerable, and cost-effectiveness uncertain. "
|4.||Highly Active Antiretroviral Therapy (HAART)
09/01/2005 - "To study effects of electroacupuncture at Jiaji (EX-B2) on protracted withdrawl syndrome of the patient of heroin dependence. "
09/01/2005 - "[Clinical study on electroacupuncture at Jiaji (EX-B2) for interfering protracted withdrawal syndrome in the patient of heroin dependence]."
04/01/1980 - "The present study was undertaken to evaluate if plasma or CSF beta-endorphin level can be induced to rise during the treatment of heroin addiction by electroacupuncture. "