Hernia (Hernias)

Protrusion of tissue, structure, or part of an organ through the bone, muscular tissue, or the membrane by which it is normally contained. Hernia may involve tissues such as the ABDOMINAL WALL or the respiratory DIAPHRAGM. Hernias may be internal, external, congenital, or acquired.

Also Known As:

Networked: 7582 relevant articles (267 outcomes, 628 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hernia (Hernias)
2.	Pain (Aches)
3.	Inguinal Hernia (Direct Inguinal Hernia)
4.	Postoperative Pain
5.	Incisional Hernia

Experts

1.	Rosenberg, Jacob: 31 articles (11/2022 - 09/2005)
2.	Rosen, Michael J: 28 articles (04/2022 - 06/2005)
3.	Heniford, B Todd: 26 articles (02/2022 - 10/2002)
4.	Köckerling, F: 26 articles (01/2022 - 02/2003)
5.	Schumpelick, V: 23 articles (02/2013 - 01/2001)
6.	Klinge, U: 22 articles (08/2014 - 01/2001)
7.	Köckerling, Ferdinand: 20 articles (03/2022 - 02/2012)
8.	Augenstein, Vedra A: 19 articles (02/2022 - 11/2014)
9.	Junge, K: 17 articles (08/2014 - 01/2002)
10.	Poulose, Benjamin K: 16 articles (01/2022 - 04/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hernia:

1.	Polypropylenes (Polypropylene)IBA 12/01/2018 - "The use of polypropylene mesh for contaminated and dirty strangulated hernias is effective and safe, with acceptable morbidity and good short-term results." 10/01/2004 - "From a surgeon's point of view, the mesh plug repair is superior to the Lichtenstein technique and the Prolene Hernia System in terms of operating time, incision length, perceived difficulty, and surgeon's satisfaction." 11/01/2004 - "In conclusion, the suturing of fascial defect and the use of polypropylene mesh extraperitoneally is effective in the treatment of parastomal hernia." 11/01/1999 - "In our experience the use of marlex mesh may be effective in treatment of parastomal hernia only a patient treated with translocation of the stoma showed a recurrence of parastomal hernia. " 04/16/2021 - "The introduction of alloplastic materials (meshes) in hernia surgery has improved patient outcome by a radical reduction of hernia recurrence rate, but discussion about the biocompatibility of these implanted materials continues since observations of surface alterations of polypropylene and other alloplastic materials were published. "
2.	tetra-4-amidinophenoxypropane (TAPP)IBA 10/01/2020 - "When performed by an experienced surgeon with excellent technique, the TAPP technique is safe and effective for recurrent hernia after surgical treatment via the anterior repair, and maybe a good alternative for recurrent hernia after surgical treatment via the posterior repair." 10/01/2008 - "A variety of commonly encountered inguinal and groin hernias were treated by TAPP with good results, minimal morbidity (4.39%) and one mortality. " 01/01/2023 - "TAPP is feasible and effective for female patients with groin hernias, especially in preserving the round ligament of the uterus." 10/01/1996 - "Our results support other studies and randomized trials reported in the literature and demonstrate that TAPP is an effective and safe operative procedure especially for the repair of recurrent groin hernias." 01/01/2020 - "The aim of this video is to evaluate the efficacy of TAPP (laparoscopic transabdominal preperitoneal) in order to treat a GIS hernia. "
3.	tetraethylpyrazine (TEP)IBA 07/01/2003 - "In a representative patient population with recurrent hernia, we were able to demonstrate that TEP achieves very good results in terms of re-recurrence rate, intraoperative and postoperative complications, and rehabilitation. " 01/01/2021 - "Modified laparoscopic Sugarbaker repair of a parastomal hernia with the TEP technique is safe and effective, although the recurrence rate and late complications require confirmation in more cases with long-term follow-up." 09/01/2021 - "TEP-IHR in hemophiliacs with RT is feasible and as effective for preventing hernia recurrence as in NH-patients. " 11/25/2023 - "Therefore, R-TEP is safe and effective for both primary and secondary lumbar hernia. " 03/01/2011 - "Therefore, the purpose of this study was to determine the safety and efficacy of transection of the hernia sac during laparoscopic TEP. "
4.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 01/01/2020 - "Cauterisation of hernia sac and injection of fibrin sealant also show promising results but are mainly derived from small studies. " 10/01/2007 - "The present study aims to evaluate the efficacy of mesh fixation with human fibrin glue (Tissucol) in open, tension-free inguinal repair, in the treatment of soccer players with groin hernia. " 07/01/2012 - "The aim of this systematic review is to summarize the clinical safety and efficacy of Tisseel/Tissucol fibrin sealant for hernia mesh fixation. " 11/01/2013 - "The study could not differentiate between different hernia defect sizes, and future studies should therefore explore whether the superior effect of fibrin sealant applies for all hernia types and sizes." 08/01/2013 - "Patients with larger hernia defects and fibrin sealant mesh fixation had higher recurrence rates than expected, although the study was not powered for assessment of recurrence. "
5.	hydroxide ionIBA 08/01/2022 - "The diagnosis of OH is challenging because of symptomatic variations and spontaneous reduction in hernia on imaging. " 12/26/2018 - "This approach establishes the diagnosis of OH, avoids injuring obturator vessels, gives improved exposure of the obturator canal, enables identification and simultaneous repair of other pelvic hernias, and facilitates bowel resection. " 02/01/1994 - "Therefore, this prospective randomized study was undertaken to compare the clinical and functional results of laparoscopic colotomy closure performed using the Endopath EMS hernia stapler (EMS; Ethicon Endosurgery Inc., Cincinnati, OH) to results of using standard two-layer hand suturing (HS). " 07/01/2023 - "Compared with OH, LHE led to fewer or equivalent testicular complications without increasing ipsilateral hernia recurrence. " 01/01/2023 - "The right hernia orifice was sutured, and OH was diagnosed during the operation. "
6.	CollagenIBA 08/01/2011 - "For parastomal hernias within the rectus sheath, diisocyanate cross-linked porcine dermal collagen mesh onlay repair gives good results and is safe to use. " 10/01/2016 - "However, a trend in pathologic studies suggests a link between abnormal collagen production and/or processing that is likely associated with hernia development." 02/01/2015 - "This study aimed to investigate the effectiveness of porcine dermal collagen (PDC) as a closing aid in giant hernias after OLT in a prospective trial. " 10/13/2008 - "Studies have shown that a reduced type-I/III collagen ratio predisposes to the development of hernias. " 10/01/2008 - "Parastomal hernia prevention using a novel collagen implant: a randomised controlled phase 1 study."
7.	diclofenac hydroxyethylpyrrolidine (DIEP)FDA Link 10/01/2022 - "The primary outcome of the study was the development of post-DIEP abdominal bulge or hernia. " 04/01/2006 - "This is the first study to use a standardized ultrasound protocol to evaluate hernia and abdominal wall laxity following free transverse rectus abdominis myocutaneous (TRAM) and deep inferior epigastric perforator (DIEP) flap surgery. " 11/01/2023 - "As bulge is the more common abdominal morbidity after DIEP flap harvest in a patient with no prior abdominal surgery or risk factor for hernia, mesh use is not indicated in abdominal closure of all DIEP patients. " 11/01/2023 - "Mesh use was significantly associated with decreased odds of hernia alone with DIEP flap surgery, but there was no difference in bulge or combined hernia/bulge rates. " 11/01/2023 - "The purpose of this systematic review is to evaluate DIEP donor-site closure techniques and the impact of mesh type and plane on abdominal-wall morbidity including hernia and bulge, relative to primary fascial closure. "
8.	SuspensionsIBA 11/01/2018 - "Transvaginal uterosacral ligaments suspension provides a safe and effective technique for enterocele repair without the use of prosthetic materials. " 11/01/2022 - "Concomitant pelvic reconstructive surgery was defined as either an apical suspension, enterocele repair, or colporrhaphy. " 11/01/2018 - "A 55-year-old woman with symptomatic stage 3 enterocele was admitted for transvaginal uterosacral ligaments suspension according to the described technique. " 12/01/2006 - "Laparoscopic vaginal vault suspension and enterocele repair." 06/01/2004 - "Vaginal suspension procedures with mobilisation of the rectum provided satisfactory results for severe enterocele over the short term."
9.	AtropineFDA LinkGeneric 05/01/1934 - "A Case of Strangulated Hernia Relieved by Atropine." 12/01/1931 - "Two Cases of Irreducible Hernia Relieved by Atropine Sulphate." 12/01/1929 - "A Case of Irreducible Hernia Relieved by Atropine Sulphate." 09/01/1934 - "Atropine in Strangulated Hernia." 04/01/1932 - "The Mode of Action of Atropine in the Reduction of Hernia."
10.	Polytetrafluoroethylene (Teflon)FDA Link 04/01/2023 - "The incarcerated stomach was repositioned, and the hernia orifice was closed and reinforced with expanded polytetrafluoroethylene mesh using a thoracoscopic procedure. " 06/01/2017 - "This adverse event was managed successfully by laparoscopic repair of the hernia and the use of a polytetrafluoroethylene mesh closure with hepatic buttress, achieving an excellent result. " 01/01/2016 - "The Sugarbaker technique for parastomal repair using e-PTFE mesh may be suitable as a standard method for treating parastomal hernia." 01/01/2016 - "The Sugarbaker technique with e-PTFE mesh (Dualmesh®) performed via open surgery was adopted for seven patients with parastomal hernia. " 04/01/2011 - "If a PTFE mesh is used with the keyhole technique parastomal hernia is likely to recur."

Therapies and Procedures

1.	Herniorrhaphy 07/01/2021 - "Retromuscular mesh hernia repair using Rives-Stoppa technique has demonstrated the best results when it comes to repairing large midline hernias. " 09/01/2019 - "The most common complications following a hernia repair are recurrent hernia and chronic -discomfort but recurrence rates have improved with the use of mesh and laparoscopic techniques. " 08/01/2015 - "During a follow-up period after bariatric operation and hernioplasty the hernia recurrence have occurred in 3 (9.1%) patients, after hernioplasty--in 11 (33.3%), witnessing high efficacy of staged treatment in such patients." 12/01/2005 - "Our experience which is similar to what can be found in numerous other articles showed, that LH is beneficial (short hospitalisation, early return to normal activity, more favourable operability in bilateral and recurrent hernias, early recognition of contralateral occult hernias, performance of synchronous laparoscopic operations, small recurrence rate, improved surgical training) so it should be rightly considered as the gold standard of inguinal hernioplasties." 10/01/1999 - "Lichtenstein "mesh" hernioplasty can solve every anatomical situation in hernia recurrence and good results, with little or any complications, are achievable; "plug" technique is easier but recurrences in other sites of a weak inguinal wall are possible."
2.	Sutures (Suture) 04/01/2012 - "After clearance of the abdominal wall from adhesions, laparoscopic central closures were performed transcutaneously with 0-polypropelene sutures placed every 1 cm of the defect starting at the cranial-most edge of the hernia and ending at the caudal-most edge of the hernia. " 08/01/2019 - "The patient underwent a full laparoscopic surgery that allowed the reduction of the hernia and the suture of the defect with very good outcome." 06/01/2014 - "The parastomal hernia rate was significantly greater in the anterior fascial suture group (43 of 281; 15.3%) than the no fascial suture group (12 of 164; 7.3%; P=.02). " 04/01/2009 - "In our experience, the incision of the peritoneum lateral to the internal inguinal ring and the W-shaped suture, compared to the sole W-shaped suture, is safe and effective in preventing hernia recurrence." 09/01/2000 - "The authors believe prosthetic "tension free" repair, previous suture of the defect, represents a gold standard in the treatment of Spigelian hernia. "
3.	Colostomy 01/01/2022 - "To evaluate the efficacy of prophylactic mesh placement during end colostomy formation at reducing rates of parastomal hernia using the most recently available data. " 01/01/2017 - "For parastomal hernia prevention, only the retromuscular prophylactic mesh and its use for end colostomies has been proven to be effective and safe. " 09/01/2016 - "For parastomal hernia prevention, only the retromuscular prophylactic mesh and its use for end colostomies has been proven to be effective and safe. " 11/03/2023 - "The cumulative incidence of parastomal hernia was significantly greater with transperitoneal colostomy than extraperitoneal colostomy at 2 and 3 years postoperatively (16.2% vs. 0, p = 0.025, and 21.6% vs. 0, p = 0.005). " 01/01/2022 - "There remains a significant reduction in the risk of parastomal hernia with the use of prophylactic mesh at the time of end colostomy formation, despite recent evidence suggesting no difference. "
4.	Ligation 06/13/2023 - "We aimed to evaluate the efficacy of laparoscopic high hernia sac ligation in adolescent indirect hernia. " 06/13/2023 - "Analysis of the efficacy of laparoscopic high hernia sac ligation in adolescent indirect hernia." 01/01/2023 - "Single-site laparoscopic ligation of the hernia sac provides pediatric surgeons a safe and effective technique for repair of CMH in infants and children. " 09/01/2012 - "Laparoscopic hernia sac transection and intracorporeal ligation can be a safe and effective alternative for conventional herniotomy." 04/01/2023 - "This study aimed to evaluate the outcomes in AYA patients undergoing high ligation or mesh repair under laparoscopy by examining the location and size of the hernia orifice defect. "
5.	Prostheses and Implants (Prosthesis) 04/01/1984 - "The good results reported allow the statement that, without ruling out classic techniques for simpler cases, surgical repair using prostheses offers an excellent opportunity for use and for preventing the recurrence of hernias." 02/01/2010 - "It is hoped that these suggestions will lead to the development of improved hernia treatments and a maximally effective portfolio of hernia mesh prostheses." 03/01/2008 - "Inserting a mesh prosthesis by this technique is a safe effective treatment for parastomal hernia, adding another option to the available repair solutions. " 01/01/2017 - "In the age of synthetic prostheses most of hernia studies include a careful examination of the various types of prosthesis, their characteristics and their repair indications. " 07/01/2016 - "Primary prevention of peristomial hernias via parietal prostheses: A randomized, multicentric study (GRECCAR 7 trial)."