A man-made compound previously used to control termites and other insects. Even though production of heptachlor was phased out of use in the United States during the late 1980's it remains in soil and hazardous waste sites. It is clearly toxic to animals and humans but, the International Agency for Research on Cancer (IARC) has determined that heptachlor is not classifiable as to its carcinogenicity to humans. (From ATSDR Public Heath Statement, April 1989)
Also Known As:
4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-
Networked: 66 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Shin, Ki Soon: 2 articles (01/2014 - 08/2013)
2. Kim, Joo Yeon: 2 articles (01/2014 - 08/2013)
3. Hong, Seokheon: 2 articles (01/2014 - 08/2013)
4. Kang, Shin Jung: 2 articles (01/2014 - 08/2013)
5. Hwang, Joohyun: 2 articles (01/2014 - 08/2013)
6. Hoppin, Jane A: 2 articles (10/2013 - 02/2007)
7. Richardson, Jason R: 2 articles (09/2008 - 08/2005)
8. Miller, Gary W: 2 articles (09/2008 - 08/2005)
9. Caudle, W Michael: 2 articles (09/2008 - 08/2005)
10. Ghali, Ridha: 1 article (07/2015)

Related Diseases

1. Body Weight (Weight, Body)
2. Birth Weight (Birth Weights)
3. Neoplasms (Cancer)
4. Leukemia
5. Breast Neoplasms (Breast Cancer)
04/01/1996 - "Taken together, these results suggest that heptachlor and heptachlor epoxide can alter GJIC at the post-translational level, and that, under the conditions of exceeding a threshold concentration in the breast tissue containing 'initiated' cells for a long time and not being counteracted by anti-tumor-promoting chemicals, they could act as breast tumor promoters."
04/01/1997 - "This paper discusses breast cancer patterns in Hawaii in the context of documented episodes of exposure to two endocrine-disrupting chemicals, chlordane/heptachlor and 1,2-dibromo-3-chloropropane (DBCP), at levels that sometimes exceeded federal standards by several orders of magnitude. "
07/01/2015 - "In the unadjusted models, β-hexachlorocyclohexane (β-HCH), hexachlorobenzene, heptachlor, polychlorinated biphenyl congeners 138, 153, and 180, and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) were positively associated with breast cancer risk. "
11/01/2002 - "The present study was therefore planned to determine whether the levels of these pesticides like DDT and its metabolites DDD and DDE, dieldrin, heptachlor, and HCH and its isomers (alpha, beta, and gamma) were higher in blood of breast cancer patients when compared with normal women who did not suffer from major diseases like blood pressure, tuberculosis, diabetes, thyroid dysfunction, arthritis, cancer, etc. and had not undergone any major surgery. "
03/01/2014 - "Activity of the sinusoidal influx transporter OCT1 (organic cation transporter 1) was thus inhibited by endosulfan, chlordane, heptachlor, lindane, and dieldrine, but not by dichlorodiphenyltrichloroethane isomers, whereas those of the canalicular efflux pumps MRP2 (multidrug resistance-associated protein 2) and BCRP (breast cancer resistance protein) were blocked by endosulfan, chlordane, heptachlor, and chlordecone; this latter OC additionally inhibited the multidrug resistance gene 1 (MDR1)/P-glycoprotein (P-gp) activity. "

Related Drugs and Biologics

1. Chlordan (Chlordane)
2. DDT
3. Dieldrin
4. Toxaphene
5. Dichlorodiphenyl Dichloroethylene (DDE)
6. Pentachlorophenol (Sodium Pentachlorophenate)
7. Chlorinated Hydrocarbons
8. oxychlordane
9. Dichlorodiphenyldichloroethane (DDD)
10. Heptachlor Epoxide

Related Therapies and Procedures

1. Oral Administration