HEPES

A dipolar ionic buffer.

Also Known As:

HEPES Monosodium Salt; Monosodium Salt, HEPES; N 2 Hydroxyethylpiperazine N' 2' ethanesulfonic Acid; Salt, HEPES Monosodium; N-2-Hydroxyethylpiperazine-N'-2'-ethanesulfonic Acid; 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-

Networked: 183 relevant articles (5 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Loh, Shih-Hurng: 6 articles (06/2018 - 05/2002)
2.	Tsai, Chien-Sung: 5 articles (08/2015 - 05/2002)
3.	Chang, Chung-Yi: 3 articles (06/2018 - 10/2005)
4.	Kim, Jae-Sung: 3 articles (04/2012 - 06/2004)
5.	Lemasters, John J: 3 articles (04/2012 - 06/2004)
6.	Jin, Jong-Shiaw: 3 articles (10/2005 - 05/2002)
7.	Aalbersberg, Else A: 2 articles (05/2020 - 01/2019)
8.	Geluk-Jonker, Martine M: 2 articles (05/2020 - 01/2019)
9.	Stokkel, Marcel P M: 2 articles (05/2020 - 01/2019)
10.	Buttachon, Suradet: 2 articles (12/2017 - 01/2016)

Related Diseases

1.	Acne Vulgaris 06/01/2021 - "Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris." 06/01/2021 - "To assess the efficacy of a serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperpigmentation and controlling skin oiliness in Brazilian patients with acne vulgaris. " 03/01/2013 - "This study evaluated the tolerance and efficacy of 2 facial skin products in subjects with acne using the following acne treatments: 1) treatment A, a combination of salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid, and 2) treatment B (BenzaClin®, clindamycin 1% and benzoyl peroxide 5% gel). " 03/01/2013 - "Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris."
2.	Acidosis 09/01/2010 - "HEPES ameliorates this acidosis and decreases allograft cell destruction. " 01/01/2021 - "A similar metabolic acidosis and recovery was found when fish were exposed to 60-ppt HCO3--free seawater (HEPES-buffered), which may suggest that compensation for intestinal base loss during hypersaline treatment is from gill H+ excretion rather than gill HCO3- uptake. " 05/01/2000 - "When cells in HEPES-buffered medium at normal pH = 7.70 were transferred to normal CO2/HCO3(-)-buffered medium ¿PCO2 = 3.71 mmHg, [HCO3-] = 6.1 mmol l(-1), extracellular pH (pHe) = 7.70¿, they exhibited a brief acidosis but subsequently regulated the same pHi (approximately 7.41) as in HEPES. " 10/01/1990 - "Under these conditions, the NH4Cl-induced 22Na+ influx rate stimulated by intracellular acidosis was markedly attenuated in HEPES-buffered PSS but not in CO2/HCO3(-)-buffered PSS. " 10/01/1990 - "The recovery of pHi from an equivalent intracellular acidosis was more rapid when the cells were incubated in CO2/HCO3(-)-buffered PSS than in HEPES-buffered PSS. "
3.	Ischemia 01/01/2002 - "Experimental group (group E), after ischemia, was perfused with pH 6.8, pH 7.1 and pH 7.4 HEPES-KH solutions for 5 min, 5 min, and 20 min, respectively. " 05/01/1993 - "The H+ efflux rate during reperfusion, after 10 minutes of global ischemia, was 15.5 +/- 1.9 mmol.l-1 x min-1 (n = 10) in hearts perfused with HCO3(-)-buffered medium and 8.2 +/- 1.5 mmol.l-1 x min-1 (n = 9, p < 0.01) in hearts perfused with HEPES-buffered medium. " 12/01/1993 - "Oxygenated preperfusion with buffer containing HEPES and 1.25 or 2.5 mM Ca2+ improved the metabolic and functional recovery with a decrease in the accumulation of Na+i during ischemia and in 45Ca2+ uptake during reperfusion. " 04/01/2012 - "Cultured rat hepatocytes were incubated in anoxic Krebs-Ringer-HEPES buffer at pH 6.2 for 4 h and then reoxygenated at pH 7.4 to simulate ischemia-reperfusion. " 05/01/2006 - "Myocytes were incubated in anoxic Krebs-Ringer-HEPES buffer at pH 6.2 for 3 h to simulate ischemia. "
4.	Rubella (German Measles) 04/01/1971 - "The increased sensitivity and improved agglutination and settling patterns of formalinized sheep erythrocytes in a new buffer, HEPES (N-2-hydroxyethylpiperazine N'-2'-ethanesulfonic acid), make this system more suitable for use in the rubella hemagglutination-inhibition test." 09/01/1971 - "In HEPES diluents, rubella antigens agglutinated a wide range of species of erythrocytes, and the hemagglutination reaction showed little or no dependence on low temperatures." 01/01/1977 - "Optimal conditions for the agglutination of freeze-dried erythrocytes by rubella hemagglutinin were provided when a HEPES-buffered saline at pH 6.2, containing 10(-3) M CaCl2, 0.2 per cent bovine serum albumin, and 0.0025 per cent gelatin was employed throughout as a diluent for serum, hemagglutinin, and freeze-dried erythrocyte suspension. "
5.	Hyperpigmentation 06/01/2021 - "To assess the efficacy of a serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperpigmentation and controlling skin oiliness in Brazilian patients with acne vulgaris. "

Related Drugs and Biologics

1.	Buffers
2.	Acids
3.	Citric Acid (Citrate)
4.	Salicylic Acid (2 Hydroxybenzoic Acid)
5.	glycolic acid (glycolate)
6.	Clindamycin (Cleocin)
7.	Benzoyl Peroxide
8.	capryloyl salicylic acid
9.	Bovine Serum Albumin
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Intravitreal Injections
2.	Therapeutics
3.	Microelectrodes
4.	Mastectomy (Mammectomy)
5.	Electrodes (Electrode)