|1.||Gonzalez, Frank J: 9 articles (02/2014 - 06/2004)|
|2.||Wang, Yu: 6 articles (01/2014 - 07/2003)|
|3.||Butenhoff, John L: 5 articles (03/2012 - 09/2008)|
|4.||DePierre, Joseph W: 4 articles (06/2015 - 06/2009)|
|5.||Abedi-Valugerdi, Manuchehr: 4 articles (06/2015 - 06/2009)|
|6.||Chou, Janice Y: 4 articles (09/2014 - 07/2008)|
|7.||Wanders, Ronald J A: 4 articles (07/2014 - 04/2002)|
|8.||Weinstein, David A: 4 articles (06/2013 - 04/2006)|
|9.||Michalopoulos, George K: 4 articles (01/2013 - 12/2008)|
|10.||Chang, Shu-Ching: 4 articles (03/2012 - 06/2009)|
01/01/2010 - "Comparison of these results with data from a previous gradient field study on biological variables in winter flounder, captured at 2, 5, 7, and 10 km down-current from the outfall, revealed an enlarged liver that was associated with elevated levels of detoxification of hepatic enzymes and prevalence of toxicopathic lesions in both the liver and the spleen; these were significantly greater in samples taken nearest to the outfall from the mill than at more distant sites. "
06/01/1994 - "During remission, they suddenly developed manifestations such as neurologic disturbances, hepatomegaly, increased activity of liver enzymes, and microvesicular steatosis. "
07/01/2006 - "This study was therefore designed to look at the association between clinical severity and hepatic enzymes in SCA subjects with persistent hepatomegaly (that is, lasting more than six months) in order to determine a possible role for hepatic enzymes as a biochemical index of severity. "
12/01/2015 - "Prolonged circadian disruption (12 weeks) resulted in hepatic maladaptation, manifested by a mild but significant (p < 0.05) hepatomegaly, accompanied by disturbed hepatic lipid metabolism and liver injury (indicated by increased circulating hepatic enzymes). "
05/01/2015 - "Twenty-one patients with MAS-associated AOSD underwent BM biopsy and among them, 9 patients with hepatomegaly and elevated liver enzymes underwent liver biopsy. "
|2.||Alanine Transaminase (SGPT)IBA
09/01/2013 - "The most frequent symptoms observed were hepatomegaly (92 %), increased blood alanine aminotransferase (ALAT) level (82 %), and steatosis (88 %). "
11/01/2012 - "Out of the 78 children, 34 had one or more abnormality in the form of clinical hepatomegaly, raised alanine aminotransferase (ALT) and/or echogenic liver parenchyma by ultrasound. "
07/01/2005 - "Hepatomegaly, the only clinical sign reported, was found in 10% of children and was significantly associated with a high proportion of abnormal alanine transaminase (ALT) levels (adjusted odds ratio [OR], 4.17; 95% confidence interval [CI], 1.67-10.42; P = .002). "
10/01/2006 - "Nineteen, 5 and 3 were, respectively, graded as hepatic encephalopathy grade 1, 2 and 3. All six patients in grade 2 and 3 had hepatomegaly compared to 78% in the grade 1. Four had jaundice and all were in grade 2 or 3. Mean alanine aminotransferase was 2781 U/L None of the randomly selected cases (6) had serological evidence of Hepatitis A, Hepatitis B or Dengue. "
07/01/2003 - "Adiponectin was also effective in ameliorating hepatomegaly, steatosis, and alanine aminotransferase abnormality associated with nonalcoholic obese, ob/ob mice. "
|3.||Dexamethasone (Maxidex)FDA LinkGeneric
09/02/2011 - "Pretreatment with dexamethasone almost completely prevented prolonged hepatomegaly in Aoah(-/-) mice, whereas neutralizing TNF or interleukin-1β was only partially effective. "
11/01/1998 - "High-dose treatment with dexamethasone led to reversible hepatomegaly with disturbance of liver function in three children. "
11/01/1998 - "Dexamethasone-induced hepatomegaly in three children."
10/01/2002 - "In all immunosuppressed and inoculated inoculated immunosuppressed mice,specially in those that received 5 mg/kg/day of dexamethasone, the most prominent necropsy findings were hepatomegaly and splenomegaly. "
01/01/1992 - "Two children had transiently aberrant metabolite profiles, indicating altered beta-oxidation, (levels of 2-en-VPA, 2,3'-dien-VPA, and 3-en-VPA were markedly increased) in connection with hepatomegaly and increased liver enzyme activities at a time when both had febrile infections and were receiving dexamethasone comedication. "
06/16/2009 - "More importantly, hepatomegaly is independent of PPARalpha, the thymic changes are partially dependent on this receptor, and splenic responses are largely eliminated in its absence. "
07/01/2009 - "Administration of PFBA can cause peroxisome proliferation, induction of peroxisomal fatty acid oxidation and hepatomegaly, suggesting that PFBA activates the nuclear receptor, peroxisome proliferator-activated receptor-alpha (PPAR-alpha). "
01/01/2007 - "Here, we show that targeted deletion of coactivator PRIP gene in liver (PRIP(LIV-/-)) does not affect the induction of PPARalpha-regulated pleiotropic responses, including hepatomegaly, hepatic peroxisome proliferation, and induction of mRNAs of genes involved in fatty acid oxidation system, indicating that PRIP is not essential for PPARalpha-mediated transcriptional activity. "
01/01/2006 - "WY-fed WT mice exhibited hepatomegaly, an effect not found in WY-fed PPARalpha-null mice, and WY did not change liver sphingoid base concentrations in either strain. "
05/18/2004 - "In light of the fact that all six compounds stimulated similar or identical changes in the expression of this set of 1288 genes, these results indicate that hepatomegaly is due to PPARalpha activation, although signaling through other receptors (e.g. "
05/15/1997 - "Yet, hepatomegaly, a characteristic effect of TCDD, took place in all three strains of mice. "
05/01/1996 - "In both species, thymic antrophy, indicating immune dysfunction, and hepatomegaly were observed as consequences of TCDD exposure. "
04/01/1993 - "In contrast, this analysis indicated that the non-TCDD component of the OPL antagonized the ability of the TCDD component to induce hepatic AHH activity whereas OPL hepatomegaly was caused primarily by the non-TCDD component of the OPL. "
02/01/1989 - "However, TCDD produced hepatomegaly, a decrease in serum antibody, and a decrease in PFC/spleen in both BALB/cByJ and DBA/2J mice to 3 and 15%, respectively, at 16 micrograms/kg. Thus, the TCDD dose required to cause a 50% suppression (ED50) of PFC/spleen for the BALB/cByJ and DBA/2J strains was 1.84 and 3.89 micrograms/kg, respectively. "
02/01/1989 - "The results suggest that the immunosuppression caused by OPL in BALB/cByJ mice was primarily due to TCDD, that the non-TCDD components of OPL diminished the TCDD immunotoxicity in the DBA/2J strain, and that the thymic atrophy and hepatomegaly were caused primarily by the non-TCDD components of the OPL."
|6.||Prednisolone (Predate)FDA LinkGeneric
08/01/2000 - "Resolution of raised jugular venous pressure (p = 0.017), hepatomegaly (p = 0.007), and ascites (p = 0.015), and improvement in physical activity (p = 0.02), were significantly more rapid in the prednisolone treated patients. "
01/01/2009 - "We report a case of hepatic hemangioendothelioma in an 8- month-old female infant who presented with hepatomegaly and respiratory distress, which was successfully treated with oral prednisolone for six months."
09/01/1987 - "A combination of vincristine (VCR) and prednisolone (PDN) was partially effective against the lymphadenopathy, but the hepatomegaly and leukocytosis did not improve. "
10/14/2009 - "Dietary KO supplementation caused a significant reduction in liver wt (i.e., hepatomegaly) and total liver fat (i.e., hepatic steatosis), due to a dose-dependent reduction in hepatic triglyceride (mean +/- SEM: 35 +/- 6, 47 +/- 4, and 51 +/- 5% for HFKO1.25, -2.5, and -5.0 vs HF, respectively, P < 0.001) and cholesterol (55 +/- 5, 66 +/- 3, and 71 +/- 3%, P < 0.001). "
10/15/2014 - "Hepatomegaly and deposition of esterified cholesterol (EC) in multiple organs ensue. "
01/01/2014 - "obesus fed a cholesterol-supplemented diet exhibited profound hepatomegaly and steatosis, and higher plasma transaminase levels. "
06/01/2013 - "Dietary switch expanded adipose tissue and decreased hepatomegaly by lowering triglyceride, cholesterol ester, free cholesterol and diacylglyceride content of liver. "
01/01/2012 - "Mice with liver specific conditional ablation of Mig-6 develop hepatomegaly and increased intrahepatic lipid and provide a novel model system to investigate the genetic and molecular events involved in the regulation of cholesterol homeostasis and bile acid synthesis. "
|8.||Aspartate Aminotransferases (Aspartate Transaminase)IBA
07/01/1976 - "Fifty-two percent had hepatomegaly and derangements of SGOT and LDH. "
05/01/1975 - "Clinical findings included fever (101-108 F); 100%; leucocytosis, 71%; anorexia and vomiting, 50%; localized tenderness and hepatomegaly, 50%; hypoalbuminemia, 86%; hypocholesterolemia, 78%; elevated SGOT, 71%; and elevated aikaline phosphatase, 43%. "
06/23/1979 - "The usual symptoms, occurring with variable incidence, include anorexia, nausea and vomiting, abdominal pain, fever and jaundice in the presence of hepatomegaly, leukocytosis and an elevated SGOT. "
07/01/2011 - "Hepatomegaly along with increases in serum aspartate-aminotransferase and alkaline-phosphatase levels were seen in rats. "
10/01/1998 - "Serum ferritin, hepatomegaly, and serum aspartate aminotransferase were selected using multivariate analysis. "
|9.||Blood Glucose (Blood Sugar)IBA
01/01/2012 - "We found that NEt-3IB induced lower degrees of hepatomegaly and blood triglyceride (TG) elevation than the other RXR agonists, even though all of them showed similar blood glucose-lowering action on repeated administration. "
01/01/2009 - "Examination revealed mild hepatomegaly and a random blood sugar of 30.2 mmol/l. "
05/01/2007 - "Examination revealed mild hepatomegaly and a random blood sugar of 30.2 mmol/l. "
07/01/1993 - "At one month after admission, a marked shrinkage of her enlarged liver and restoration of normal liver function were observed concomitantly with the return of fair control of her blood sugar levels. "
04/15/2015 - "Despite strict diet control to maintain blood glucose, patients with GSD1a develop hepatomegaly, steatosis and then hepatocellular adenomas (HCA), which can undergo malignant transformation. "
03/01/2013 - "Hepatomegaly on ultrasound was more common among cirrhotic human immunodeficiency virus/hepatitis C virus co-infected patients than among cirrhotic hepatitis C virus mono-infected patients. "
11/01/2005 - "Analysis of variance as part of SPSS statistical package was used where common bile duct was considered a dependent variable, while sex, fasting status, hepatomegaly and previous cholecystectomy were considered to be independent variables, age and sex were considered as co-variants. "
03/01/2013 - "Also, there was a strong correlation between hepatomegaly and co-infection (p=0.005). "
03/01/2013 - "Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients."
10/01/2011 - "Twenty-eight patients with psoriasis concurrent with CO, 15 patients with CO, 15 patients with the enlarged liver, and 15 healthy individuals were examined. "
|1.||Drug Therapy (Chemotherapy)
04/01/1984 - "In another one, follow-up study after chemotherapy showed improvement of hepatomegaly, stabilization of renal function, and regression of light chain deposits in skin biopsy specimens."
11/01/2006 - "The remaining 2 patients were treated with chemotherapy due to progressive hepatomegaly and respiratory distress. "
03/01/2006 - "Treatment reduction should be considered for subsets of infants with non-MYCN-amplified widespread NB: stage 4 without bone or extensive BM involvement may not require cytotoxic therapy, stage 4S with symptomatic hepatomegaly may not require multiple cycles of chemotherapy, and classic stage 4 may do well with limited chemotherapy. "
12/01/2004 - "But we have to treat with chemotherapy neonates with massive hepatomegaly and children with one or more unfavorable prognostic factors (unfavorable histology, high MYC-N copy number)."
03/01/2004 - "Previous systemic chemotherapy and malignant hepatomegaly were associated with a poorer ORR (P=0.033, P=0.016) and OS (P=0.008, P=0.045). "
07/01/1978 - "Analysis of subgroups showed that splenectomy was definitely beneficial in women, in patients with a Hb level over 8.0 g/dl or a platelet level above 50 X 10(9)/1, in patients with leucocytes below 3 X 10(9/1, , and also in patients with hepatomegaly (P less than .05 in all cases). "
06/01/2015 - "Because this patient presented with hepatomegaly before the splenectomy and because hepatic dysfunction rapidly progressed after surgery, an early diagnosis of EBV+T-LPD was crucial. "
08/01/1997 - "Although the patient felt well during 18 months after the splenectomy was done, the patient eventually manifested a huge hepatomegaly, showed increasing white blood cell count to 42 x 10(9)/l, and numerous prolymphocytes (66.9%) in the bone marrow. "
11/01/1996 - "Vertebral density remained an independent predictor of the severity of bone involvement even after controlling for age, sex, weight, genotype, splenectomy, and hepatomegaly. "
01/01/1990 - "Hepatomegaly and a number of granulocytic foci in the liver were observed in STIL-3 inoculated mice, but this was again abrogated completely by the splenectomy. "
|3.||Surgical Portacaval Shunt (Portacaval Anastomosis)
09/01/2011 - "As the huge hepatomegaly caused a notorius deterioration in the patient's quality of life, we decided to include her in the waiting list for liver transplantation. "
07/01/2010 - "In a minority of patients, severe symptomatic hepatomegaly necessitates liver transplantation (LT). "
03/21/2010 - "Liver transplantation for polycystic liver and massive hepatomegaly."
10/28/2009 - "Liver transplantation for polycystic liver with massive hepatomegaly: a case report."
06/01/2003 - "The major indications for liver biopsy in those with normal ALT were unexplained hepatomegaly (n = 21) and evaluation as a potential donor for living donor liver transplantation (n = 16). "