Alcoholic Hepatitis

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637 relevant articles (41 outcomes, 90 trials/studies) found for this Disease

Description: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of Mallory hyaline bodies. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.

Also Known As:

Hepatitis, Alcoholic; Alcoholic Hepatitis, Chronic; Chronic Alcoholic Hepatitides; Chronic Alcoholic Hepatitis; Hepatitis, Alcoholic, Chronic

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 29

Liver Diseases: 19065

Hepatitis: 17019

Alcoholic Hepatitis: 637

Alcoholic Liver Diseases: 1674

Alcoholic Hepatitis: 637

Disorders of Environmental Origin

Substance-Related Disorders: 5511

Alcohol-Related Disorders: 35

Alcohol-Induced Disorders: 4

Alcoholic Liver Diseases: 1674

Alcoholic Hepatitis: 637

Related Diseases

1.	Fibrosis (Cirrhosis)
2.	Hepatic Encephalopathy
3.	Fatty Liver
4.	Alcoholic Liver Diseases (Alcoholic Liver Disease)
5.	Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis)

Experts

1.	Mathurin, Philippe: 8 articles (03/2008 - 03/2002)
2.	Naveau, Sylvie: 5 articles (06/2007 - 04/2002)
3.	Dharancy, Sébastien: 3 articles (03/2008 - 05/2004)
4.	Jalan, Rajiv: 3 articles (01/2007 - 04/2003)
5.	Williams, Roger: 3 articles (01/2007 - 04/2003)
6.	Mookerjee, Rajeshwar P: 3 articles (01/2007 - 04/2003)
7.	Chaput, Jean-Claude: 3 articles (03/2005 - 04/2002)
8.	Hadengue, Antoine: 3 articles (12/2004 - 10/2002)
9.	Rubbia-Brandt, Laura: 3 articles (12/2004 - 10/2002)
10.	Spahr, Laurent: 3 articles (12/2004 - 10/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Alcoholic Hepatitis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 04/01/2002 - "Even if corticosteroids are beneficial for alcoholic hepatitis, they are not recommended for all patients at risk" 10/01/1999 - "Corticosteroids are effective in patients with severe alcoholic hepatitis." 01/01/1993 - "It is thus easy to show that corticosteroids are effective in severe acute alcoholic hepatitis, i.e" 08/01/2007 - "This trial was devised to determine whether antioxidant therapy, alone or as an adjunct to corticosteroids, improved survival in patients with acute alcoholic hepatitis" 02/20/1992 - "Controlled trials have yielded inconsistent results with regard to the efficacy of corticosteroids in the treatment of alcoholic hepatitis" Order ALL the reference details at left...
2.	Oxandrolone (Anavar)FDA LinkGeneric 09/01/1991 - "We conclude that the addition of nutritional supplementation and oxandrolone to standard therapy of moderately severe or severe alcoholic hepatitis is well tolerated, and leads to more rapid improvement in the laboratory parameters measured." 11/01/1993 - "PATIENTS: A cohort of 273 male patients enrolled in a Department of Veterans Affairs Cooperative Study performed to evaluate the efficacy of oxandrolone in combination with nutritional supplementation in moderate or severe alcoholic hepatitis" 04/01/1993 - "A Veterans Affairs cooperative study involving 273 male patients was performed to evaluate efficacy of oxandrolone in combination with an enteral food supplement in severe alcoholic hepatitis" 07/01/1995 - "BACKGROUND: Active nutrition therapy and the anabolic steroid oxandrolone (OX), in selected patients with severe alcoholic hepatitis, significantly improved liver status and survival" 04/01/1993 - "A study of oral nutritional support with oxandrolone in malnourished patients with alcoholic hepatitis: results of a Department of Veterans Affairs cooperative study." Order ALL the reference details at left...
3.	Prednisolone (Predate)FDA LinkGeneric 03/01/1980 - "Twenty-eight patients entered a double-blind controlled trial to evaluate the efficacy of prednisolone treatment in severe acute alcoholic hepatitis accompanied by encephalopathy" 12/01/2007 - "This study aimed to elucidate the contribution of GILZ to the pathogenesis of alcoholic hepatitis (AH): we (1) assessed GILZ expression in the livers of patients with AH and (2) treated patients with severe AH with GCs (prednisolone 40 mg/day) and studied the effect of GILZ modulation on circulating monocyte function" 02/20/1992 - "A randomized trial of prednisolone in patients with severe alcoholic hepatitis." 03/01/1980 - "Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy." 08/01/1978 - "Fifty-five patients with alcoholic hepatitis were studied in a 28- to 32-day randomized double blind treatment trial comparing prednisolone (40 mg per day) with placebo therapy" Order ALL the reference details at left...
4.	Pentoxifylline (Trental)FDA LinkGeneric 12/01/2000 - "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial." 11/01/2007 - "In cases of severe acute alcoholic hepatitis, pentoxifylline can be administered." 01/01/2002 - "Is pentoxifylline the answer for alcoholic hepatitis?" 12/01/2000 - "Pentoxifylline and alcoholic hepatitis." 01/01/2008 - "Pentoxifylline appears to be beneficial in patients with alcoholic hepatitis, especially those with early hepatorenal syndrome" Order ALL the reference details at left...
5.	Ethanol (Ethyl Alcohol)IBA 10/01/2002 - "CONCLUSIONS: Our study suggests that PAF is an important mediator of hepatic injury in the ethanol/endotoxin model of alcoholic hepatitis." 03/15/2002 - "Therefore, in this study, a long-term intragastric ethanol feeding model was used to test the hypothesis that LBP is involved in alcoholic hepatitis by comparing LBP knockout and wild-type mice" 12/01/2005 - "All patients with alcoholic hepatitis consumed more than 80 g of ethanol/day for more than 10 years" 12/01/2004 - "CONCLUSIONS: In conclusion, ethanol intake per se plays an important role in the pathogenesis of ALD, except with the HCC in heavy drinkers and chronic alcoholic hepatitis types" 08/01/2004 - "Consequently, although plasma LCFA are unaltered, hepatocellular LCFA uptake in ethanol-fed rats is also increased~3-fold, leading to increased ROS generation and evolution of alcoholic hepatitis" Order ALL the reference details at left...
6.	Propylthiouracil FDA Link 05/01/1982 - "Sixty-seven patients entered a double-blind, controlled trial to evaluate the efficacy of propylthiouracil treatment in severe alcoholic hepatitis" 01/01/1984 - "Studies in which the effectiveness of propylthiouracil is tested in human alcoholic hepatitis are discussed." 05/01/1982 - "Double-blind, controlled trial of propylthiouracil in patients with severe acute alcoholic hepatitis." 01/01/1989 - "The most notable development has been the introduction of propylthiouracil for the treatment of alcoholic hepatitis" 10/01/1982 - "Propylthiouracil treatment for alcoholic hepatitis: the case of the missing thirty." Order ALL the reference details at left...
7.	Insulin (Novolin)FDA Link 06/01/1981 - "Insulin and glucagon infusion is a promising treatment of alcoholic hepatitis and merits further study in the most severely ill patients." 10/01/1987 - "Insulin and glucagon infusion appears to be a promising treatment of acute alcoholic hepatitis." 01/01/1992 - "Treatment of severe alcoholic hepatitis by infusion of insulin and glucagon: a multicenter sequential trial." 12/01/1991 - "This study does not confirm previous reports that insulin and glucagon infusion improves the outcome of severe acute alcoholic hepatitis." 06/01/1981 - "A randomized, double-blind, controlled trial of insulin and glucagon infusion was conducted in 50 patients with acute alcoholic hepatitis" Order ALL the reference details at left...
8.	Glucagon (Glukagon)FDA Link 06/01/1981 - "Insulin and glucagon infusion is a promising treatment of alcoholic hepatitis and merits further study in the most severely ill patients." 10/01/1987 - "Insulin and glucagon infusion appears to be a promising treatment of acute alcoholic hepatitis." 01/01/1992 - "Treatment of severe alcoholic hepatitis by infusion of insulin and glucagon: a multicenter sequential trial." 12/01/1991 - "This study does not confirm previous reports that insulin and glucagon infusion improves the outcome of severe acute alcoholic hepatitis." 06/01/1981 - "A randomized, double-blind, controlled trial of insulin and glucagon infusion was conducted in 50 patients with acute alcoholic hepatitis" Order ALL the reference details at left...
9.	NitrogenIBA 11/01/1979 - "Enteral hyperalimentation in four patients with severe alcoholic hepatitis and anorexia increased spontaneous food intake, increased their nitrogen balance and the patients improved clinically" 01/01/1985 - "Sixty-four patients admitted with acute alcoholic hepatitis, with or without underlying cirrhosis, were randomized regardless of encephalopathy to receive a controlled diet either alone, or supplemented orally, nasogastrically, or intravenously as necessary, with 2000 kCal and 10 g nitrogen daily" 01/01/1995 - "Relationship between direct toxicity and nutritional deficiencies in pathogenesis of alcoholic liver injury are not clear enough, but malnutrition is generally present in patients requiring hospitalization, and related to clinical severity; oral, enteral or parenteral nutritional supplementation in this order of preference according to patients condition, associated or not with steroid anabolics, are useful in cases with moderate to severe alcoholic hepatitis or decompensated cirrhosis to eliminate the catabolic state, reaching a better nitrogen balance and liver function tests, without special adverse effects" 02/01/1982 - "In addition, plasma amino acids were correlated with nitrogen balance in patients with acute alcoholic hepatitis and with clinical improvement in patients with encephalopathy" 09/01/1991 - "The present studies were designed to provide careful measures of effects of oxandrolone, an anabolic steroid, intravenous nutritional supplementation, and the combination of these two treatments on liver functions, metabolic balances, nitrogen metabolism, and nutritional status in patients with moderate to severe alcoholic hepatitis" Order ALL the reference details at left...
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/01/2008 - "BACKGROUND: This study investigated whether genetic polymorphisms in the tumor necrosis factor alpha (TNFalpha) gene's promoter region play a role in severe acute alcoholic hepatitis (AAH)" 08/01/2004 - "CONCLUSIONS: An EP4 agonist ONO-AE1-437 suppresses excess TNF-alpha secretion from macrophages and seems promising for future trial in patients with severe alcoholic hepatitis." 04/01/2003 - "In severely ill patients with alcoholic hepatitis, drugs with anti-tumor necrosis factor alpha activity are currently investigated in clinical trials" 04/01/2003 - "Anti-tumor necrosis factor-alpha therapy in severe alcoholic hepatitis: are large randomized trials still possible?" 05/01/2000 - "The aim of this study was to investigate potential mechanisms of increased tumor necrosis factor-a activity in alcoholic hepatitis" Order ALL the reference details at left...

Therapies and Procedures

1.	Liver Transplantation 11/01/2001 - "severe alcoholic hepatitis) associated with a high mortality rate, whereas the second is the first controlled trial in the field of preoperative nutrition in liver transplantation" 05/01/1997 - "This study suggests that severe acute alcoholic hepatitis may not be an appropriate contraindication for liver transplantation." 12/01/2007 - "Patients with clinical acute alcoholic hepatitis (AAH) are not considered suitable candidates for orthotopic liver transplantation (OLT)" 12/01/2007 - "The impact of acute alcoholic hepatitis in the explanted recipient liver on outcome after liver transplantation." 04/10/2005 - "Severe alcoholic hepatitis resulting in liver transplantation: the first case in Japan]" Order ALL the reference details at left...
2.	Nutritional Support (Artificial Feeding) 03/01/1996 - "Individuals with severe alcoholic hepatitis require intensive nutritional support and vigorous management of the complications of their liver injury; their outcome is generally poor" 11/01/1987 - "The etiology of malnutrition and the metabolic effect of aggressive nutritional support by enteral feeding were evaluated in patients with moderately severe alcoholic hepatitis" 01/01/1994 - "Special emphasis will be paid to the role of artificial nutritional support in the treatment of acute alcoholic hepatitis, the current status of artificial nutrition in advanced cirrhosis, and some nutritional implications in the management of hepatic encephalopathy." 04/01/1993 - "A study of oral nutritional support with oxandrolone in malnourished patients with alcoholic hepatitis: results of a Department of Veterans Affairs cooperative study." 05/01/2005 - "For alcoholic hepatitis, nutritional support is the mainstay of treatment; steroids are considered by some (but not all) as safe and effective therapy, whereas manipulations of tumor necrosis factor-alpha activity have been disappointing, or of unproven benefit at best" Order ALL the reference details at left...
3.	Nutrition Therapy (Medical Nutrition Therapy) 07/01/1995 - "BACKGROUND: Active nutrition therapy and the anabolic steroid oxandrolone (OX), in selected patients with severe alcoholic hepatitis, significantly improved liver status and survival" Order ALL the reference details at left...
4.	Parenteral Nutrition 10/01/1988 - "A randomized controlled study of peripheral parenteral nutrition in moderate and severe alcoholic hepatitis." 10/01/1988 - "Twelve patients with moderate and 22 with severe alcoholic hepatitis were randomized to 28 days of peripheral parenteral nutrition (PPN) or standard therapy (ST)" 09/01/1991 - "A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone" 09/01/1991 - "A randomized, controlled trial of treatment of alcoholic hepatitis with parenteral nutrition and oxandrolone" Order ALL the reference details at left...
5.	Laparoscopic Cholecystectomy 04/01/1997 - "Among them are those that question the strength of the association of Helicobacter pylori with gastric cancer, the usefulness of surveillance endoscopy in patients with Barrett's esophagus, a randomized trial that casts doubt on the preeminence of laparoscopic cholecystectomy, and a metaanalysis that concludes that corticosteroids may not be nearly as good for alcoholic hepatitis as we were once told" Order ALL the reference details at left...

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