Heparitin Sulfate (Heparan Sulfate)

01/01/2008 - "This strategy of targeting heparan sulfate may be particularly effective for attacking cancers like myeloma where extensive genetic chaos renders them unlikely to respond well to agents that target a single signaling pathway."
01/01/2018 - "This study considers a possible novel mechanism of Ext1-regulated heparan sulfate structure in modifying tumor-stroma interactions through altering stromal tgf-ß1 expression."
11/08/2005 - "In the current study, we further examined the residues in NKp46 that may be involved in heparan sulfate binding on tumor cells. "
01/22/2002 - "In the present study, the importance of sequence information contained within tumor cell-surface heparan sulfate was investigated. "
12/01/2023 - "Collectively, we reveal novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in cancer. "

09/15/2015 - "Butanolysis derivatization: improved sensitivity in LC-MS/MS quantitation of heparan sulfate in urine from mucopolysaccharidosis patients."
10/01/2021 - "Competitive binding of extracellular accumulated heparan sulfate reduces lysosomal storage defects and triggers neuronal differentiation in a model of Mucopolysaccharidosis IIIB."
02/01/2016 - "A novel LC-MS/MS assay for heparan sulfate screening in the cerebrospinal fluid of mucopolysaccharidosis IIIA patients."
02/27/2015 - "Heparan sulfate saccharides modify focal adhesions: implication in mucopolysaccharidosis neuropathophysiology."
09/01/2014 - "Novel heparan sulfate assay by using automated high-throughput mass spectrometry: Application to monitoring and screening for mucopolysaccharidoses."

01/01/2023 - "Together, our findings identify an ACE2-independent SARS-CoV-2 infection mechanism that involves cooperative interactions with the receptors heparan sulfate and TMEM106B."
01/01/2023 - "SARS-CoV-2 receptor binding domains (RBDs) interact with both the ACE2 receptor and heparan sulfate on the surface of host cells to enhance SARS-CoV-2 infection. "
10/01/2022 - "Spike-heparan sulfate interactions in SARS-CoV-2 infection."
04/01/2022 - "In conclusion, our data highlight the link between endothelial glycocalyx degradation, barrier failure and induction of a procoagulant surface in COVID-19 patients in ICU which could be targeted earlier in disease by the presence of heparan sulfate mimetics."
01/01/2021 - "We identify heparan sulfate as an important attachment factor for SARS-CoV-2 infection. "

03/05/2010 - "Unique extracellular matrix heparan sulfate from the bivalve Nodipecten nodosus (Linnaeus, 1758) safely inhibits arterial thrombosis after photochemically induced endothelial lesion."
03/01/2021 - "Heparan sulfate consumption as a potential mechanism of intra-cardiac thrombosis in SARS-CoV-2 infection."
01/01/1991 - "A heparan sulfate-related preparation (suleparoide) was much less effective in both thrombosis models, especially in the venous one, while the activity was most specifically directed to the maintenance of endothelial stability."
12/15/2021 - "SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate."
04/24/2012 - "Both heparin and heparan sulfate are known to be potent inhibitors of thrombosis. "

01/18/2005 - "Moreover, human liver heparan sulfate shows higher degree of sulfation than heparan sulfate isolated from porcine liver or from the human hepatoma Hep 2G cell line."
08/01/1998 - "Structural characterization and functional effects of a circulating heparan sulfate in a patient with hepatocellular carcinoma."
03/01/1989 - "A rat hepatoma cell line (Gershenson et al., Science, 170:859-861, 1970) contains a dynamic steady-state pool of free heparan sulfate (HS) chains in the nucleus that increases in amount when growing cells reach confluence (Fedarko and Conrad, J. "
03/01/1989 - "Correlations between heparan sulfate metabolism and hepatoma growth."
06/01/2013 - "Evidence supporting ApoE as a major determinant arose from its enrichment in TRLs from mice defective in hepatic heparan sulfate (Ndst1f/fAlbCre⁺ mice), decreased binding of ApoE-deficient TRLs to HSPGs on human hepatoma cells, and decreased clearance of ApoE-deficient [³H]TRLs in vivo. "