Hemorrhoids

Swollen veins in the lower part of the RECTUM or ANUS. Hemorrhoids can be inside the anus (internal), under the skin around the anus (external), or protruding from inside to outside of the anus. People with hemorrhoids may or may not exhibit symptoms which include bleeding, itching, and pain.

Also Known As:

Networked: 1591 relevant articles (157 outcomes, 259 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhoids
2.	Hemorrhage
3.	Prolapse
4.	Pain (Aches)
5.	Postoperative Pain

Experts

1.	Gupta, P J: 12 articles (12/2011 - 04/2003)
2.	Gupta, Pravin J: 12 articles (11/2008 - 05/2002)
3.	Lohsiriwat, Varut: 6 articles (03/2022 - 12/2005)
4.	Yang, Wei: 6 articles (02/2021 - 05/2005)
5.	Akkol, Esra Küpeli: 6 articles (10/2020 - 12/2008)
6.	Li, Jun: 6 articles (08/2019 - 03/2015)
7.	Long, Qing: 6 articles (08/2019 - 03/2015)
8.	Wen, Yong: 6 articles (08/2019 - 03/2015)
9.	Garg, Pankaj: 5 articles (02/2022 - 06/2017)
10.	Abe, Tatsuya: 5 articles (01/2022 - 07/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemorrhoids:

1.	Diosmin (Daflon)IBA 04/01/2014 - "Both Roidosanal(®) and Daflon(®) 500 mg were equally effective in resolving signs and symptoms of hemorrhoids. " 06/01/1994 - "The author reports the results of a double-blind, placebo-controlled trial of the efficacy of Daflon 500 mg in the treatment of acute and chronic symptoms of hemorrhoids. " 12/01/2002 - "Efficacy of Daflon in the treatment of hemorrhoids." 04/01/2014 - "In this pilot, active controlled, open-labeled multicentre study, 73 patients with proctoscopy proven hemorrhoids (Grade I to III) were randomly assigned to receive either Roidosanal(®) (Gr R; n = 37) or Daflon(®) 500 mg (Gr D; n = 36), for 15 days, at three centers in India. " 11/27/2022 - "Diosmin is widely used in the treatment of chronic venous diseases and hemorrhoids. "
2.	Ointments (Pastes)IBA 01/01/2017 - "communis was also effective in treating patients who did not respond to current chemical treatments (anti-hemorrhoids ointment). " 10/31/2013 - "Many different ointments are currently used to treat hemorrhoids; however, there is little evidence of the efficacy of these treatments to support their use. " 09/14/2021 - "This study examined its efficient delivery to the dermis through the pharmaceutical improvement of hemorrhoid treatment ointments. " 08/14/2023 - "The most commonly used treatment for hemorrhoids during pregnancy was topical ointments, with only a small proportion (1.8%) of patients requiring procedure or surgery." 08/14/2023 - "Of the pregnant women, 31% received oral medication, and 93.2% used the topical ointment to treat their hemorrhoids. "
3.	Lidocaine (Xylocaine)FDA LinkGeneric 10/01/2020 - "One hundred seventeen patients diagnosed with hemorrhoids and scheduled to undergo a stapled hemorrhoidopexy (SH) were randomly divided according to submucosal injection to the rectum: lidocaine group (n = 53, lidocaine injected just before full closure of the stapler) and control group (n = 58). " 03/01/1999 - "In the treatment group rubber band ligation was performed at three columns of hemorrhoids, and 1 to 2 ml of 2 percent lignocaine was injected into the banded hemorrhoidal tissue. " 07/21/2017 - "A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine. " 01/01/2019 - "In pregnant women, the tribenoside/lidocaine combination significantly improved both subjective and objective symptoms of hemorrhoids. " 01/01/2023 - "The combination of tribenoside and lidocaine (Procto-Glyvenol©, Recordati) has been used for decades to treat low-grade hemorrhoids, and its efficacy and safety are well supported by clinical experience. "
4.	Polidocanol (Laureth)FDA Link 03/01/2022 - "The present study aimed to evaluate the efficacy and safety of polidocanol foam in the treatment of symptomatic internal hemorrhoids." 07/01/2021 - "Patients with grade 3 hemorrhoids required a significantly larger amount of polidocanol than those with grade 2 hemorrhoids. " 06/01/2021 - "We decided to treated 10 urgent cases affected from III- and IV-degree hemorrhoids with 3% polidocanol foam in attempt to reduce hemorrhoidal symptoms while waiting for surgery so called "bridge treatment". " 05/01/2019 - "Polidocanol Foam: A Breath of Fresh Air for the Treatment of Internal Hemorrhoids." 05/01/2019 - "Polidocanol Foam Injected at High Doses with Intravenous Needle: The (Almost) Perfect Treatment of Symptomatic Internal Hemorrhoids."
5.	Dietary FiberFDA Link 09/01/1995 - "A positive result was achieved in the study of the action of a concentrate of food fibre prepared from wheat bran by special methods in patients with hemorrhoids. " 06/01/2017 - "Adequate dietary fiber supplement and TONE can help avoid surgery in most patients with advanced hemorrhoids." 11/01/1994 - "Almost half of the patients suffering from hemorrhoids of grade 1 or grade 2 are treated successfully and conservatively (regulation of bowel habits by intake of large quantities of dietary fiber, change of life style and training of sphincter ani). " 02/01/1995 - "Dietary fiber has significant gastrointestinal effects, and it is a mainstay of treatment for constipation and hemorrhoids. " 11/01/1996 - "Addition of dietary fiber may improve internal bleeding hemorrhoids although with no immediate effect. "
6.	TabletsIBA 07/01/2017 - "In this study, Apamarga Kshara application, infrared coagulation (IRC) procedure and Arshohara Vati (AV) tablet were administered for the management of internal hemorrhoid (Arsha). " 05/01/1968 - "[Effects of oral tablet Fragivix in hemorrhoids]." 11/01/1970 - "[Determination of clinical effect on the chemotherapy of internal hemorrhoid, with special reference to the double blind test of Fragivix tablet]." 05/01/2003 - "Zhiranxiao tablets are also effective in the treatment of internal hemorrhoid hemorrhage." 05/01/2005 - "Fuhuang Tablets are effective and safe in treating internal hemorrhoid hemorrhage."
7.	aluminum sulfate (alum)IBA 06/01/2011 - "Aluminum potassium sulfate and tannic acid (ALTA) injection as the mainstay of treatment for internal hemorrhoids." 07/21/2017 - "We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid (ALTA) regimen. " 07/21/2017 - "Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids." 06/01/2015 - "Aluminum Potassium Sulfate and Tannic Acid - A New Option for the Treatment of Grade 3 Hemorrhoids." 05/01/2014 - "Aluminum potassium sulfate and tannic acid injection (ALTA) is a useful and less-invasive treatment for internal hemorrhoids. "
8.	LaxativesIBA 05/01/1985 - "High-fibre diets and bulk laxatives are effective in relieving the symptoms of hemorrhoids, easing defecation and regulating bowel habit and can be used liberally. " 10/01/2013 - "They randomly received CM 3 g/d for 4 weeks (as study group) or LandA (Lactolose syrup in laxative dose for 1 month and anti-hemorrhoid suppository daily for 10 days) as control group. " 05/01/2017 - "Mallaw (Malva sylvestris L.) is a medicinal plant who is traditionally being used as an antiulcer, laxative and anti-hemorrhoid, besides of its culinary use as a food in Tunisian cuisine. " 07/01/2002 - "No significant difference was shown between the two groups in terms of age, duration of stimulant laxative-use before the first prescription of rhubarb, shape of stool, abdominal symptoms, existence of hemorrhoids, or duration of rhubarb-use. " 11/01/1992 - "Servier, Orléans, France) and placebo to a conservative regimen of bulk laxative in the treatment of acute symptoms of first-degree and second-degree internal hemorrhoids was undertaken in 100 patients. "
9.	Tannic AcidFDA Link 06/01/2011 - "Aluminum potassium sulfate and tannic acid (ALTA) injection as the mainstay of treatment for internal hemorrhoids." 07/21/2017 - "We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid (ALTA) regimen. " 07/21/2017 - "Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids." 06/01/2015 - "Aluminum Potassium Sulfate and Tannic Acid - A New Option for the Treatment of Grade 3 Hemorrhoids." 05/01/2014 - "Aluminum potassium sulfate and tannic acid injection (ALTA) is a useful and less-invasive treatment for internal hemorrhoids. "
10.	Suppositories (Vaginal Suppositories)IBA 04/01/1978 - "The treatment of hemorrhoids should be started by instructing the patient on anal hygiene, to be followed only then by symptomatic application of creams or suppositories. " 09/01/1976 - "A combined use of the nonoperative method and proctoglivenol suppositories is a rather effective therapeutic measure, which is indicated for treatment of hemorrhoids in patients, in whom operative intervention is contraindicated." 12/01/2011 - "To alleviate symptoms caused by hemorrhoids, oral treatments, such as fiber, suppositories and Sitz baths have been applied to patients. " 04/01/1986 - "[Belladonna poisoning after the use of hemorrhoid suppositories]." 09/01/1997 - "Physician examiners diagnosed significantly more hemorrhoids among those using primarily suppositories and enemas to manage their bowels (P < 0.05) and more constipation among persons with paraplegia (P < 0.05) and those using digital stimulation, manual evacuation, or increased abdominal pressure in their bowel programs. "

Therapies and Procedures

1.	Ligation 08/01/1979 - "Elastic ligature of internal hemorrhoid nodules was done ambulatorily with good results and no important complications. " 02/01/2011 - "Doppler-guided hemorrhoidal artery ligation is a minimally invasive technique for the treatment of symptomatic hemorrhoids that has been applied successfully for grade II and III hemorrhoids but is less effective for grade IV hemorrhoids. " 12/01/2002 - "Endoscopic hemorrhoidal ligation is a safe and effective technique indicated for the treatment of grade 1 to 3 hemorrhoids, with a high success and low complication rate. " 12/01/1986 - "We have then reported about the good results obtained with 162 patients suffering from stage 2, 3 and 4 hemorrhoids, by using band ligation. " 09/01/2022 - "Rubber band ligation of hemorrhoids: is the procedure effective for the immunocompromised, hemophiliacs and pregnant women?"
2.	Hemorrhoidectomy 03/01/2017 - "Hemorrhoidectomy is considered the gold standard and the most effective and definitive treatment for grades 3 or 4 hemorrhoids, and Milligan-Morgan's and Ferguson's procedures are the most widely used techniques throughout the world. " 10/18/2006 - "The Milligan‐Morgan open hemorrhoidectomy is the most widely practiced surgical technique used for the management of hemorrhoids and is considered the current "gold standard". " 09/01/1996 - "Hemorrhoidectomy is one of the most effective treatments for significantly symptomatic hemorrhoids. " 04/01/1977 - "Eighty-five patients who had thrombosed hemorrhoids underwent emergency hemorrhoidectomy according to St. Mark's Hospital technique, with very good results. " 09/01/2007 - "Conventional hemorrhoidectomy is superior to stapled hemorrhoidopexy for prevention of postoperative recurrence of internal hemorrhoids. "
3.	Therapeutics 06/01/2005 - "Medical therapy is the best treatment option for hemorrhoids and anal fissures. " 10/01/2018 - "Nonoperative management of chronic anal fissures and hemorrhoid disease is associated with significant improvement in patient-reported outcome scores in several domains, suggesting that dietary counseling and medical therapy should be the first-line outpatient therapy for these diseases. " 05/01/1989 - "current therapy is associated with less discomfort and fewer complications and that Ultroid therapy may yield good results in some patients with third- or even fourth-degree hemorrhoids." 07/06/2022 - "ERBL therapy is an effective treatment for symptomatic internal hemorrhoids with satisfactory short and long-term recovery. " 01/01/2016 - "Enough evidence exists to recommend the use of this combination therapy as a fast, effective and safe option for the local treatment of low-grade hemorrhoids."
4.	Sclerotherapy 06/01/2011 - "ALTA sclerotherapy is a simple and safe treatment for symptomatic hemorrhoids, with few complications." 04/01/2002 - "In conclusion, the approach of banding or sclerotherapy of hemorrhoids in SCI patients is safe and effective. " 12/25/2015 - "To evaluate the methodology, feasibility, safety and efficacy of a novel method called cap-assisted endoscopic sclerotherapy (CAES) for internal hemorrhoids. " 09/19/2023 - "Positive efficacy of Lactiplantibacillus plantarum MH-301 as a postoperative adjunct to endoscopic sclerotherapy for internal hemorrhoids: a randomized, double-blind, placebo-controlled trial." 01/01/2020 - "The outcome of this study is expected to provide a practical clinical protocol of cap-assisted endoscopic sclerotherapy for patients with internal hemorrhoids and promote the use of this new endoscopic technique. "
5.	Lasers (Laser) 01/25/2023 - "There is a paucity of studies assessing the benefits or harms of laser dearterialization for the treatment of hemorrhoids and randomized trials are furthermore rare, therefore trials with adequate power and proper design, assessing the advantages and disadvantages of HeLP versus other minimally invasive techniques, are needed. " 05/19/2022 - "Laser hemorrhoidoplasty in the treatment of symptomatic hemorrhoids: a pilot Australian study." 03/01/2022 - "We selected 11 studies both techniques HeLP (hemorrhoid laser procedure) and LHP (laser hemorrhoidoplasty procedure). " 03/01/2022 - "The purpose of this literature review was to study the results of laser treatment of hemorrhoids and to compare them with those of surgical methods. " 04/01/2021 - "Laser treatment is increasingly used in the treatment of symptomatic hemorrhoids, and several studies have attempted to describe its clinical outcomes. "