|1.||Hemorrhagic Fever with Renal Syndrome (HFRS)
|3.||Hantavirus Pulmonary Syndrome
|1.||Jin, Boquan: 13 articles (10/2015 - 09/2004)|
|2.||Zhuang, Ran: 13 articles (10/2015 - 11/2004)|
|3.||Zhang, Yun: 13 articles (10/2015 - 02/2009)|
|4.||Ma, Ying: 12 articles (10/2015 - 08/2010)|
|5.||Ahlm, Clas: 12 articles (10/2015 - 08/2007)|
|6.||Yang, Angang: 12 articles (04/2015 - 09/2004)|
|7.||Zhang, Chunmei: 10 articles (10/2015 - 01/2012)|
|8.||Wang, Jiuping: 10 articles (06/2015 - 01/2009)|
|9.||Zhang, Yusi: 9 articles (10/2015 - 01/2012)|
|10.||Yi, Jing: 9 articles (04/2015 - 01/2012)|
|1.||Ribavirin (Virazole)FDA LinkGeneric
07/01/2006 - "Ribavirin is the most effective in the treatment for HFRS. "
07/01/2008 - "Clinical studies using ribavirin (RBV) to treat HFRS patients suggest that it provides an improved prognosis when given early in the course of disease. "
01/01/1995 - "Limited clinical studies evaluating ribavirin as a therapeutic modality demonstrated that the agent improves clinical outcome in HFRS. "
08/01/2014 - "Treatment with Ribavirin helps in HFRS but not in HPS. "
01/01/2011 - "Ribavirin, a drug associated with toxicities, is presently indicated for treatment of HFRS, whereas treatment of the more frequently lethal HCPS is limited to supportive care. "
01/01/2008 - "Convalescent-phase antibodies may represent a potential therapy that can induce immediate protection against HFRS and HPS."
12/01/2007 - "To develop and evaluate a method for detection of the total antibodies against hemorrhagic fever with renal syndrome (HFRS) virus with improved sensitivity and simplified operation procedure. "
01/01/2009 - "The objective (purpose) of this study was to investigate the prevalence of specific antibodies in HFRS, in convalescent persons (collective immunity in endemic hearths). "
01/01/2004 - "[A study on detecting specific antibodies of hemorrhagic fever with renal syndrome and treatment with integrated traditional Chinese and western medicine]."
08/01/1994 - "[The study on ELISA methods for detection of specific antibodies against hemorrhagic fever with renal syndrome virus in rat sera]."
11/05/2009 - "Because of the global distribution of hantaviruses, the historical association of HFRS-causing viruses with military operations and the recent emergence of the HPS-causing viruses, efforts are continuing to develop safe and effective hantavirus vaccines. "
07/17/2014 - "Early clinical studies of HFRS vaccines expressing Hantaan virus or Puumala virus genes have been completed and show promise for further development. "
10/01/2008 - "The descriptive study on epidemiological characteristics of HFRS in the recent years had provided scientific evidence for vaccination strategy, suggesting the key regions, sub-populations as well as types of vaccines be determined."
01/01/2012 - "These findings may have significant implications for the development of genetically engineered vaccines for HFRS."
03/23/2007 - "There are still no effective prophylactic vaccines directed to HFRS until now. "
03/01/2004 - "[Experimental study on enzyme dot assay for detection of hemorrhagic fever with renal syndrome antigen]."
11/01/1993 - "[A study on gastric mucosa damage, antigen location, and virus dissociation in patients with epidemic hemorrhagic fever]."
02/01/1988 - "[A study on the early diagnosis of epidemic hemorrhagic fever by ELISA for examining antigens in urine]."
12/01/1984 - "[Animal reservoirs of epidemic hemorrhagic fever--experimental studies and identification of the specificity of rat lung antigens. "
01/01/2014 - "coli as representative antigens of three groups (HFRS, NE and HPS-causing viruses) of hantavirus. "
|5.||Immunoglobulin M (IgM)IBA
07/01/2007 - "The rNP-IgM direct capture ELISA that established in this study could be used as a new serological test for HFRS diagnosis because of its simplicity, safety, with high sensitivity and specificity."
02/01/2007 - "Detection of Hantavirus CAg with a MAb-based sandwich ELISA (MBS-ELISA) established in the present study adds a new diagnostic tool for HFRS, and it increases the diagnostic rate to conventional specific IgM detection, especially for patient in the early stage of HFRS."
11/01/2014 - "The results were evaluated with a serum panel containing serum samples from laboratory-confirmed CHIK, HFRS patients, healthy donors, and commercially available CHIKV IgM as a quality control. "
07/01/2007 - "94.73% (90/95) of HFRS patients' serum samples were positively confirmed by rNP-IgM direct capture ELISA, while a positive rate of 92.63% (88/95) in the same samples was confirmed by HV-IgM indirect capture ELISA. "
07/01/2007 - "Western blot assay was used to determine the specific immuno-reactivity of rNP while HRP-labeled rNP-IgM direct capture ELISA was established to detect the serum samples from 95 cases of confirmed HFRS patients. "
|6.||Immunoglobulin G (IgG)IBA
03/01/2012 - "Absorbance (A) value of HFRS-IgG was 4 times higher in persons with vaccination than those without, in the epidemic area. "
03/01/2012 - "Level of HFRS-IgG was detected with ELISA in epidemic and non-epidemic areas of HFRS. "
09/01/2001 - "The number of sera collected (July 1994-July 1998) in vaccine group immunized type B inactivated vaccine against HFRS and control group were 305 and 283 persons in Jiande County respectively, and indirect immunofluorescent antibody method(IFAT) was used for testing the titer of HFRS IgG in sera. "
03/01/1995 - "The injury mechanism is that the immuno complexes (IgG) are deposited in testis tissues from HFRS autopsies."
09/01/1992 - "The test proved to have similar sensitivity and specificity as an IgG ELISA and indirect immunofluorescence test, when screening 187 sera (with an antibody prevalence rate of 19%) from normal populations in an endemic area of Nephropathia epidemica (NE) in Sweden. "
09/01/2013 - "To explore the relationship between Hantaan (HTNV)-specific CD8(+) T lymphocytes and the immune pathogenesis of HFRS, the levels of interferon γ (IFN-γ) secreted by HTNV-specific CD8(+) T lymphocytes were detected by flow cytometry in peripheral blood mononuclear cells. "
09/01/2002 - "[Interferon in patients with hemorrhagic fever with renal syndrome]."
01/01/1994 - "Serum levels of alpha and gamma interferons in hemorrhagic fever with renal syndrome."
11/01/1987 - "Effects of human and murine interferons against hemorrhagic fever with renal syndrome (HFRS) virus (Hantaan virus)."
12/01/2014 - "Our data show that serum levels of interferon (IFN)-γ, interleukin (IL)-10, CCL2, and IL-12 are upregulated in HFRS cases when compared to healthy controls and the level of upregulation is dependent on the phase and severity of the disease. "
|8.||Complementary DNA (cDNA)IBA
10/31/2013 - "In this study, we successfully cloned the cDNA of CD306 from the peripheral blood mononuclear cells (PBMCs) of patients with hemorrhagic fever with renal syndrome. "
01/01/1987 - "Radiolabeled RNA probes generated from cDNA clones of the M and S genome segments of Hantaan virus readily detected Hantaan virus and two isolates from Korean hemorrhagic fever patients but were less effective in detecting four other hantaviruses."
01/01/1990 - "The S segment RNA of nephropathia epidemica virus (NEV) strain Hällnäs B1 was isolated by molecular cloning of the corresponding cDNA. "
07/01/1991 - "The L RNA segment of the nephropathia epidemica virus (NEV) strain Hällnäs B1 was characterized by molecular cloning of the corresponding cDNA and subsequent determination of the DNA nucleotide sequence. "
10/01/1989 - "The M genome RNA segment of nephropathia epidemica virus (NEV) strain Hällnäs B1 was characterized by molecular cloning and DNA nucleotide sequencing of the corresponding cDNA clones. "
|9.||Anti-Bacterial Agents (Antibiotics)IBA
01/01/1995 - "Whether preventive antibiotics are beneficial in hemorrhagic fever with renal syndrome was checked up by the evidence obtained from 303 relevant case histories. "
01/01/2001 - "Clinico-laboratory comparisons were conducted in patients with HFRS who received antibiotics (n = 153) and did not (n = 104) in combined treatment of their disease. "
01/01/2001 - "To evaluate effects of antibiotics in the treatment of hemorrhagic fever with renal syndrome (HFRS). "
01/01/2001 - "HFRS patients treated with antibiotics had weakness, poor appetite, hyperemia of the face, enanthema, hemorrhagic eruption, coated tongue, abdominal distention, thirst, xerostomia, oligoanuria, polyuria significantly longer. "
01/01/1995 - "173 case records have been analyzed to specify the role of early therapy (antipyretics, antibiotics, sulphanilamide drugs) on further development of hemorrhagic fever with renal syndrome. "
05/01/1999 - "Three kinds of inactivated vaccines against HFRS (the golden hamster kidney cell vaccine, the Mongolian gerbil kidney cell vaccine and the purified suckling mouse brain vaccine) have been successively developed and proved highly effective in the prevention of HFRS. "
09/15/2008 - "In this study, we have further evaluated the adjuvanticity of recombinant ASP-1 using a panel of recombinant proteins or synthetic peptide-based antigens, including ovalbumin (OVA), synthetic HIV peptide (HIV-p), recombinant HIV gp41 (rgp41) and HBV HBsAg, as well as three commercially available inactivated vaccines against haemorrhagic fever with renal syndrome (HFRS), Influenza and Rabies. "
|1.||Renal Dialysis (Hemodialysis)
01/01/2005 - "The subjects of the study--patients with severe hemorrhagic fever with renal syndrome--were divided into two groups: those who were on hemodialysis, and those who were not. "
01/01/1999 - "To evaluate effect of hemodialysis on functional state of platelet-vascular and red cell components of hemostasis in patients suffering from severe hemorrhagic fever with renal syndrome (SHFRS). "
01/01/1996 - "All the patients with severe HFRS need inpatient treatment in hospitals with hemodialysis facilities."
05/01/1989 - "Twenty-seven patients with serologically confirmed HFRS were studied; 10 required renal dialysis, six had hemorrhagic manifestations, and four died. "
01/01/1986 - "Human sera examined for the presence of HFRS-specific antibody by the indirect fluorescence and RIA techniques were 76 serum specimens from chronic kidney patients treated by hemodialysis and 349 sera of adult males over 35 years of age coming from various districts of Bohemia and Moravia. "
|2.||Fluid Therapy (Oral Rehydration Therapy)
|3.||Patient Admission (Patient Admissions)
|4.||Chinese Traditional Medicine (Traditional Chinese Medicine)
07/01/1987 - "[Traditional Chinese medicine combined with Western medicine in the treatment of epidemic hemorrhagic fever]."
01/01/1984 - "[Experience in treating epidemic hemorrhagic fever by combined traditional Chinese medicine and western medicine--clinical analysis of 1,233 cases]."
08/01/1991 - "This article reports the treatment of 23 cases (with the control group 20 cases) of severe renal failure in patients with epidemic hemorrhagic fever (EHF) by integrated traditional Chinese medicine and western medicine (TCM-WM), i.e., the renal protective decoction and modern medical treatment during the period of 1988-1989. "
08/01/1991 - "[Traditional Chinese medicine combined with Western medicine in the treatment of severe renal failure in patients with epidemic hemorrhagic fever]."
02/01/1986 - "[Observation on the therapeutic effect of shock of 272 epidemic hemorrhagic fever patients treated with traditional Chinese medicine and western medicine]."
01/01/2011 - "Understanding the molecular details of hantavirus life cycle will help in the identification of targets for antiviral therapeutics and in the design of potential antiviral drug for the treatment of HFRS and HCPS. "
04/01/2010 - "Hantaan virus (HTNV) is the type of Hantavirus causing hemorrhagic fever with renal syndrome, for which no specific therapeutics are available so far. "
01/01/2011 - "Currently, no US FDA-approved therapeutics or vaccines are available for HFRS/HCPS. "