Crimean Hemorrhagic Fever

A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus (HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO).

Also Known As:

Hemorrhagic Fever, Crimean; Congo-Crimean Hemorrhagic Fever; Crimean-Congo Haemorrhagic Fever; Crimean-Congo Hemorrhagic Fever; Infection, Congo Virus; Congo Crimean Hemorrhagic Fever; Crimean Congo Haemorrhagic Fever; Crimean Congo Hemorrhagic Fever; Fever, Congo-Crimean Hemorrhagic; Fever, Crimean Hemorrhagic; Fever, Crimean-Congo Haemorrhagic; Fever, Crimean-Congo Hemorrhagic; Haemorrhagic Fever, Crimean-Congo; Hemorrhagic Fever, Congo-Crimean; Hemorrhagic Fever, Crimean-Congo; Congo Virus Infection

Networked: 326 relevant articles (22 outcomes, 36 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Virus Diseases: 41777
  - RNA Virus Infections: 303
    - Viral Hemorrhagic Fevers: 121
      - Crimean Hemorrhagic Fever: 326
    - Bunyaviridae Infections: 34
      - Crimean Hemorrhagic Fever: 326
  - Arbovirus Infections: 98
    - Crimean Hemorrhagic Fever: 326
- Vector Borne Diseases: 374
  - Tick-Borne Diseases: 496
    - Crimean Hemorrhagic Fever: 326
  - Arbovirus Infections: 98
    - Crimean Hemorrhagic Fever: 326

Related Diseases

1.	Infections
2.	Thrombocytopenia (Thrombopenia)
3.	Critical Illness (Critically Ill)
4.	Vaccinia
5.	Fever (Fevers)

Experts

1.	Engin, Aynur: 20 articles (01/2022 - 03/2009)
2.	Bakir, Mehmet: 13 articles (01/2022 - 03/2009)
3.	Kaya, Ali: 9 articles (03/2017 - 05/2013)
4.	Elaldi, Nazif: 9 articles (05/2015 - 10/2008)
5.	Arslan, Serdal: 7 articles (01/2022 - 11/2010)
6.	Hewson, Roger: 6 articles (10/2020 - 01/2014)
7.	Sari, Ismail: 6 articles (01/2019 - 07/2010)
8.	Koksal, Iftihar: 6 articles (12/2017 - 08/2007)
9.	Sancakdar, Enver: 6 articles (03/2017 - 01/2014)
10.	Bodur, Hurrem: 6 articles (01/2017 - 05/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Crimean Hemorrhagic Fever:

1.	Ribavirin (Virazole)FDA LinkGeneric 04/01/2014 - "Early use of ribavirin is beneficial in Crimean-Congo hemorrhagic fever." 01/01/2018 - "We do not know if ribavirin is effective for treating Crimean Congo haemorrhagic fever. " 08/01/2014 - "Is ribavirin prophylaxis effective for nosocomial transmission of Crimean-Congo hemorrhagic fever?" 11/01/1989 - "Ribavirin was evaluated as a potential therapeutic for Crimean-Congo hemorrhagic fever (CCHF). " 12/01/2014 - "The efficacy of ribavirin in Crimean-Congo hemorrhagic fever--randomized trials are urgently needed."
2.	Antiviral Agents (Antivirals)IBA 10/01/2017 - "Despite the serious public health impact of Crimean-Congo hemorrhagic fever (CCHF), the efficacy of antivirals targeting the causative agent, CCHF virus (CCHFV), remains debatable. " 01/01/2012 - "[Efficacy of antiviral agents in the treatment of Crimean hemorrhagic fever]." 03/01/2023 - "Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays." 08/19/2011 - "Severe Crimean-Congo haemorrhagic fever presented with massive retroperitoneal haemorrhage that recovered without antiviral treatment." 01/01/2022 - "Moreover, concerning the antiviral activity, another phosphoramidate 14 bearing a different aryl masking group exhibited an IC50 of 5 µM on Crimean-Congo Hemorrhagic Fever orthonairovirus. "
3.	VaccinesIBA 01/01/2022 - "Crimean-Congo haemorrhagic fever virus (CCHFV) is a highly pathogenic virus for which a safe and effective vaccine is not yet available, despite being considered a priority emerging pathogen. " 10/01/2019 - "Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine." 01/01/2022 - "Vaccine efficacy trials for Crimean-Congo haemorrhagic fever: Insights from modelling different epidemiological settings." 10/01/2023 - "Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is listed as a priority pathogen by the World Health Organization due to the severity of disease, propensity for spread to nonendemic regions, and absence of a vaccine or specific treatment. " 04/01/2023 - "Crimean-Congo hemorrhagic fever: Immunopathogenesis and recent advances in the development of vaccines."
4.	NucleoproteinsIBA 11/01/2019 - "Evaluation of Crimean-Congo Hemorrhagic Fever Orthonairovirus AviTagged Nucleoprotein for Potential Application in Diagnosis" 10/01/2016 - "Plant-produced Crimean-Congo haemorrhagic fever virus nucleoprotein for use in indirect ELISA." 07/01/2005 - "Moreover, expression of a distantly related nucleoprotein gene from Crimean-Congo hemorrhagic fever nairovirus failed to induce HAZV silencing, indicating that the inhibition is sequence specific. " 05/01/2003 - "A patient with Crimean-Congo hemorrhagic fever serologically diagnosed by recombinant nucleoprotein-based antibody detection systems." 01/01/2016 - "A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease."
5.	TabletsIBA 01/01/2012 - "The study aimed at estimating the pharmacotherapeutic efficacy of medications possessed of antiviral activity, such as ribavirin, cycloferon solution and tablets, in 410 patients with Crimean hemorrhagic fever: The early beginning of therapy (days 1-4 after the onset of the disease) with these drugs reduced the number of severe cases and manifestations of hemorrhagic syndrome. "
6.	SolutionsIBA 01/01/2012 - "The study aimed at estimating the pharmacotherapeutic efficacy of medications possessed of antiviral activity, such as ribavirin, cycloferon solution and tablets, in 410 patients with Crimean hemorrhagic fever: The early beginning of therapy (days 1-4 after the onset of the disease) with these drugs reduced the number of severe cases and manifestations of hemorrhagic syndrome. "
7.	10-carboxymethyl-9-acridanoneIBA 01/01/2012 - "The study aimed at estimating the pharmacotherapeutic efficacy of medications possessed of antiviral activity, such as ribavirin, cycloferon solution and tablets, in 410 patients with Crimean hemorrhagic fever: The early beginning of therapy (days 1-4 after the onset of the disease) with these drugs reduced the number of severe cases and manifestations of hemorrhagic syndrome. "
8.	Methylprednisolone FDA LinkGeneric 01/01/2010 - "High-dose methylprednisolone in children with Crimean-Congo haemorrhagic fever." 04/01/2013 - "Efficacy of high-dose methylprednisolone in patients with Crimean-Congo haemorrhagic fever and severe thrombocytopenia." 01/01/2013 - "The treatment of crimean-congo hemorrhagic fever with high-dose methylprednisolone, intravenous immunoglobulin, and fresh frozen plasma."
9.	favipiravirIBA 01/01/2020 - "Treatment of Crimean-Congo Haemorrhagic Fever by Favipiravir in a Patient with Novel Coronavirus Co-Infection." 01/01/2020 - "Clinicians should be alert for concomitant viral infections such as Crimean-Congo haemorrhagic fever, which share similar clinical and laboratory findings to COVID-19.The effectiveness of favipiravir for viral infections other than influenza and COVID-19, such as Crimean-Congo haemorrhagic fever, should be elucidated." 05/01/2014 - "Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever."
10.	Viral VaccinesIBA 01/01/2016 - "A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease."

Therapies and Procedures

1.	Therapeutics 05/26/2017 - "This is especially the case since there are no licensed therapeutics for some of the diseases considered by the World Health Organization as most likely to cause severe outbreaks-including Middle East respiratory syndrome coronavirus, Marburg virus, Crimean Congo haemorrhagic fever and Nipah virus. " 09/01/2015 - "As she tested negative for all routine causes of such an illness and did not show improvement to therapy, she was investigated for Crimean-Congo hemorrhagic fever and tested positive for the same. " 11/01/2016 - "Problematic issues on creation and practical introduction of specific immune biologic prepa- rations for therapy and prophylaxis of natural-foci arbovirus infections - West Nile fever (WNF) and Crimean hemorrhagic fever (CHF), that are not available until now, are examined. " 12/01/2019 - "Identification of the crucial parameters regarding the efficacy of ribavirin therapy in Crimean-Congo haemorrhagic fever (CCHF) patients: a systematic review and meta-analysis." 01/01/2009 - "Evaluation of the efficacy of ribavirin therapy on survival of Crimean-Congo hemorrhagic fever patients: a case-control study."
2.	Plasma Exchange 06/01/2021 - "Efficacy of therapeutic plasma exchange in patients with Crimean-Congo hemorrhagic fever." 06/01/2021 - "To examine the efficacy of therapeutic plasma exchange (TPE) in patients critically ill with Crimean-Congo hemorrhagic fever (CCHF). " 07/01/2011 - "A case of Crimean-Congo haemorrhagic fever successfully treated with therapeutic plasma exchange and ribavirin." 10/01/2021 - "The first pediatric case of hemophagocytic lymphohistiocytosis secondary to Crimean-Congo haemorrhagic fever successfully treated with therapeutic plasma exchange accompanying ribavirin and intravenous immunoglobulin."
3.	Plasmapheresis 12/01/2021 - "Crimean-Congo hemorrhagic fever: A pediatric case responding to plasmapheresis treatment." 06/01/2013 - "Double filtration plasmapheresis for a case of Crimean-Congo hemorrhagic fever."
4.	Critical Care (Surgical Intensive Care) 12/01/2022 - "Intensive care patients diagnosed with Crimean-Congo hemorrhagic fever, between January 2012 and January 2022, were included. " 05/01/2013 - "Facts about Crimean-Congo hemorrhagic fever and the role of intensive care in treatment and outcome." 12/01/2022 - "Relationship between Systemic Immune-inflammation Index and Mortality in Intensive Care Patients Diagnosed with Crimean-Congo Hemorrhagic Fever."
5.	Semiconductors 11/01/2017 - "The performance of the panel was evaluated via serially quantified nucleic acids from Yellow fever virus, Rift Valley fever virus, Crimean-Congo hemorrhagic fever (CCHF) virus, Ebola virus, Junin virus and Chikungunya virus in a semiconductor-based sequencing platform. "