Hemorrhage

Subscribe to Selected New Research on Hemorrhage

50360 relevant articles (2879 outcomes, 4370 trials/studies) found for this Disease

Description: Bleeding or escape of blood from a vessel.

Also Known As:

Bleeding; Hemorrhages

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Esophageal and Gastric Varices (Esophageal Varices)
2.	Hemorrhage
3.	Peptic Ulcer (Peptic Ulcers)
4.	Ulcer
5.	Varicose Veins (Varicose Vein)

Experts

1.	Chaudry, Irshad H: 78 articles (10/2008 - 01/2002)
2.	Bland, Kirby I: 57 articles (10/2008 - 01/2002)
3.	Choudhry, Mashkoor A: 54 articles (10/2008 - 08/2004)
4.	Schwacha, Martin G: 40 articles (10/2008 - 01/2002)
5.	Hsieh, Ya-Ching: 29 articles (10/2008 - 08/2005)
6.	Yu, Huang-Ping: 22 articles (09/2008 - 12/2005)
7.	Shimizu, Tomoharu: 22 articles (07/2008 - 08/2004)
8.	Suzuki, Takao: 21 articles (07/2008 - 03/2006)
9.	Chaudry, I H: 21 articles (08/2006 - 01/2000)
10.	Bland, K I: 18 articles (12/2001 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemorrhage:

1.	recombinant FVIIa (rFVIIa)IBA 04/01/2006 - "After administration of the second dose of rFVIIa (120 microg/kg per dose, every 2 h), the active bleeding subsided dramatically and a significant improvement in the oxygenation index was seen 8 h after the third dose of rFVIIa treatment" 03/01/1998 - "Of 103 evaluable surgical bleeding episodes, the response to treatment with rFVIIa was considered to be either excellent or effective in 81%, 86% and 92% of major, minor and dental bleeding episodes, respectively" 05/15/2008 - "RESULTS: Treatment with 80 microg of rFVIIa per kilogram resulted in a significant reduction in growth in volume of the hemorrhage" 09/01/2007 - "There was a significant reduction in the use of all blood products following rFVIIa (p<0.001) and rFVIIa was thought to have decreased or stopped bleeding in 59% of cases" 07/01/2006 - "Patients with haematological malignancy received a significantly greater median number of doses of rFVIIa than patients with surgical bleeding complications (three versus one dose, P = 0.04)" Order ALL the reference details at left...
2.	Heparin (Liquaemin)FDA LinkGeneric 12/01/2007 - "Heparin use provides the best results but may be associated with a higher mortality rate related to intra-abdominal bleeding" 01/01/2006 - "However, heparin therapy is not always associated with a significant improvement of clinical outcomes, is linked with enhanced bleeding risk and can occasionally provoke the development of heparin-induced thrombocytopaenia, the most devastating complication of conventional therapy with unfractioned heparin" 08/01/2004 - "The aim of this study was to investigate whether clinically important bleeding attributable to heparin rebound can be eliminated by infusion of small amounts of additional protamine for 6 hours postoperatively and whether this treatment can reduce mediastinal blood loss" 11/15/1994 - "APC improved the prolonged bleeding time, but heparin aggravated bleeding with potent prolongation of activated partial thromboplastin time (APTT)" 02/01/1978 - "Neither heparin's therapeutic efficacy nor its ability to increase bleeding could be proven" Order ALL the reference details at left...
3.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 12/01/2001 - "CONCLUSIONS: Somatostatin is highly effective in controlling variceal bleeding" 01/01/1999 - "The efficacy of somatostatin in controlling bleeding in patients with non-variceal UGI bleeding at high risk of mortality upon admission, or rebleeding following endoscopy, coupled with an excellent safety and tolerability profile, suggests it may be a valuable therapeutic option in the management of non-variceal bleeding." 07/01/1998 - "The efficacy of somatostatin in controlling bleeding in patients with non-variceal UGI bleeding at high risk of mortality upon admission, or rebleeding following endoscopy, coupled with an excellent safety and tolerability profile, suggests that it may be a valuable therapeutic option in the management of non-variceal bleeding." 01/01/1999 - "Results from recent studies have indicated that somatostatin is an effective treatment for the control of non-variceal UGI bleeding in high-risk patients, i.e" 07/01/1998 - "Results from recent studies have indicated that somatostatin is an effective treatment for the control of non-variceal UGI bleeding in high-risk patients, i.e" Order ALL the reference details at left...
4.	Warfarin (Coumadin)FDA LinkGeneric 05/23/2005 - "BACKGROUND: Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-founded fear of bleeding" 07/01/1997 - "This audit of hospice inpatients taking warfarin showed a high incidence of bleeding which was possibly improved with very stringent international normalized ratio (INR) monitoring: 15 episodes in 17 patients improved to 11 episodes in 18 patients" 09/07/1999 - "Patients receiving warfarin had a significantly greater risk of any bleeding event than patients not receiving anticoagulant therapy (RR 1.79, 95% CI 1.07-3.00)" 04/01/1992 - "Low dose warfarin can be used effectively without any significant bleeding complications" 09/01/2007 - "Additional study is required to determine the efficacy of warfarin and risk of bleeding complications in this population so that patients can make a more informed choice." Order ALL the reference details at left...
5.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/01/2008 - "AUTHORS' CONCLUSIONS: The available evidence suggests that the use of aspirin is associated with a statistically non-significant reduction in the risk of fatal thrombotic events, without an increased risk of major bleeding, when compared with no treatment in patients polycythaemia vera who have no clear indication or contraindication to aspirin therapy." 01/01/2004 - "Although bleeding episodes are more common with combined antiplatelet therapy for ACS than for aspirin alone, the benefit of a significant reduction in 30-day mortality appears to outweigh the risk of major bleeding" 03/01/1993 - "This was typically aspirin 1000 to 1300 mg/day, but more recently even lower doses have been beneficial, with lower rates of minor and major bleeding" 06/01/2005 - "Secondary prevention with acetylsalicylic acid is as effective as oral anticoagulation, but carries a lower bleeding risk" 01/01/1992 - "The possibility has been investigated that, after admission to hospital with acute upper gastrointestinal bleeding, patients who have been users of aspirin and non-aspirin non-steroidal anti-inflammatory drugs have poorer baseline renal function, a greater improvement in renal function during their hospital stay, and a larger transfusion requirement than non-users" Order ALL the reference details at left...
6.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 08/01/2004 - "In very high-risk patients, a higher dose of LMWH may offer increased efficacy without increasing bleeding risk" 10/01/2003 - "However the optimal LMWH regimen, offering the greatest efficacy with an acceptable risk of bleeding, has not been clearly established with regard to dose and timing of treatment initiation" 09/01/2003 - "When all studies were combined, a statistically non-significant reduction in the risk of VTE (OR 0.66; 95% confidence interval [CI] 0.41, 1.07) and in the risk of major bleeding (OR 0.45; 95% CI 0.18, 1.11) in favor of LMWH treatment was found" 11/01/1991 - "The conclusions of all these trials are: LMWH is relatively simple to use and, compared with UFH, has a more stable anticoagulant effect due to its pharmacokinetic properties; the therapeutic efficacy is as good as, if not better, than that of UFH; the risk of bleeding remains, therefore, the specified dosages should be respected and treatment should be monitored by anti-Xa activity when indicated; the decreased interaction with platelet function should not mask the risk of thrombocytopoenia.(ABSTRACT TRUNCATED AT 400 WORDS)" 12/10/2007 - "CONCLUSION: The use of intravenous LMWH during PCI is associated with a significant reduction in major bleeding events compared with UFH, without compromising outcomes on hard ischemic end points." Order ALL the reference details at left...
7.	Vasopressins (Vasopressin)IBA 09/01/1977 - "Because catheter-related complications in the SMA group were significantly greater, we concluded that the method of choice in vasopressin treatment of esophagogastric variceal bleeding is a continuous infusion by way of a peripheral vein." 07/01/1988 - "Control of bleeding was not improved with higher doses of vasopressin" 04/21/1979 - "For variceal bleeding low dose intravenous infusion of vasopressin is as effective in decreasing portal pressure and blood flow as is selective superior mesenteric infusion" 12/01/1992 - "Intra-arterial vasopressin infusion appears to be an effective method for controlling bleeding from a stapled intestinal anastomosis and can avert the need for reoperation." 10/01/1979 - "It is concluded that intraarterial vasopressin infusions are not as effective in controlling pyloroduodenal hemorrhage as in other areas of the gastrointestinal tract." Order ALL the reference details at left...
8.	Epinephrine (Adrenaline)FDA LinkGeneric 11/01/2005 - "The endoscopic examination showed an important arterial bleeding treated successfully with epinephrine and bipolar elettro-coagulation (BICAP)" 03/01/2007 - "Dieulafoy's lesion-like bleeding was treated successfully with epinephrine injection and endoscopic cauterization in 5 of 6 patients with 1 patient requiring surgery" 08/01/2003 - "Only one complication was observed after the polypectomy, a hemorrhage that was treated successfully with local injection of adrenaline" 05/01/2003 - "With regard to lesion site, hemoclipping was significantly more effective in preventing recurrent bleeding of gastric body Dieulafoy lesion than epinephrine injection therapy (0 % vs. 50 %, P < 0.05)" 05/01/2003 - "Hemoclipping was significantly more effective in preventing recurrent bleeding than epinephrine injection therapy (0 % vs. 35.7 %, P < 0.05)" Order ALL the reference details at left...
9.	Octreotide (Sandostatin)FDA LinkGeneric 09/01/2002 - "CONCLUSIONS: Octreotide appeared to be more effective in controlling acute bleeding in patients with hypertensive gastropathy, with significantly rapid action, smaller transfusion requirements, and minor side-effects" 10/01/2004 - "CONCLUSION: These results suggest that octreotide is effective in the treatment of esophageal variceal bleeding and it is a valuable adjuvant treatment in association with endoscopic management." 10/01/2004 - "Octreotide was found to be effective regarding hemostasis at 48 hours and on day 7 after the index bleeding episode" 09/01/2000 - "CONCLUSIONS: These results suggest that octreotide infusion is effective in the treatment of variceal bleeding" 12/23/1995 - "Octreotide infusion is effective for control of variceal bleeding" Order ALL the reference details at left...
10.	Factor VIII (Coagulation Factor VIII)IBA 05/01/2004 - "Porcine factor VIII was highly effective in both treating acute bleeding episodes and preventing bleeding after surgery." 12/01/1985 - "These data indicate that isolated F.VIII:C promptly complexes with vWF and in this form is highly effective in controlling hemophilic hemorrhages with good survival in plasma" 02/01/2000 - "As a result, the titer of factor VIII inhibitor was markedly improved, but the reduced activity of factor VIII was continued and re-bleeding around neck was observed" 04/01/2000 - "Effective treatment of bleeding symptoms should be based upon the clinical situation and depends on the inhibitor characteristics against human and porcine factor VIII. Immunosuppression usually does not significantly affect the disappearance of the factor VIII inhibitor antibody" 08/01/1997 - "High dose human factor VIII concentrate substitution was effective in controlling bleeding episodes in two cases of factor VIII inhibitor type II, but ineffective in 1 patient with high titre type I factor VIII inhibitor" Order ALL the reference details at left...

Therapies and Procedures

1.	Sclerotherapy 01/01/2007 - "INTRODUCTION: Successful endoscopic sclerotherapy is effective in securing hemostasis for bleeding lesions and remains the first line and only needed therapy for most of the patients (pts), but bleeding reoccurs in 10% to 30% pts, and 4% to 14% of the pts die after acute nonvariceal upper gastrointestinal bleeding (UGIB)" 10/01/1992 - "Endoscopic variceal sclerotherapy (EVS) is highly effective in arresting active esophageal variceal bleeding" 07/01/1992 - "The best treatment remains endoscopic sclerotherapy, which controls the bleeding in 90% of the cases" 02/01/1990 - "We conclude that emergency sclerotherapy, mainly with a large sclerosant volume, is highly effective in arresting active variceal bleeding" 01/01/1988 - "Sclerotherapy appears to be the most effective treatment for the majority of patients with acute variceal bleeding" Order ALL the reference details at left...
2.	Ligation 01/01/1990 - "Control of hemorrhage should be the aim of treatment, best achieved by alternative treatment, such as hepatic artery ligation of angiographic embolization, highly effective in our experience" 06/01/1982 - "They also point out the main diagnostic and therapeutic aspects emphasizing the small effect that ligation of the external carotid artery has on bleeding and the importance of choosing case by case the best treatment considering the great variety of clinical and pathologic aspects that characterize these lesions." 09/01/1981 - "Although the treatment of choice for extracranial, congenital and traumatic, AVMs is ideally total excision, careful embolization of the nidus with ligation of the feeders seems to be the most opportune procedure of choice as the second-best treatment in cases in which the nidus of the AVM occupies extensive areas of the head or face and which have little chance of developing serious signs and symptoms such as massive hemorrhage." 09/01/1979 - "Although bilateral ligation is not the answer to all problems of bleeding from the uterus, it is superior to most other procedures, and physicians providing obstetric care should be familiar with the technique" 10/01/2002 - "A significant reduction in the rate of variceal bleeding with band ligation, compared with beta-blockers, was shown in only one study" Order ALL the reference details at left...
3.	Resuscitation 12/01/2001 - "The most recent laboratory studies and the only clinical trial evaluating the efficacy of these guidelines however, suggest that in the setting of uncontrolled hemorrhage, today's practice of aggressive fluid resuscitation may be harmful, resulting in increased hemorrhage volume and subsequently greater mortality" 07/01/2005 - "RESULTS: AM-induced vascular relaxation decreased significantly after hemorrhage and resuscitation, which was markedly improved by AMBP-1" 04/01/2008 - "Studies in hemorrhaged conscious sheep suggest that: (1) a small reduction in target blood pressure can result in a significant reduction in volume requirement; (2) nonlinear algorithms may reduce the risk of increased internal bleeding during resuscitation; (3) algorithm control functions based on proportional-integral, fuzzy logic, or nonlinear decision tables were found to restore and maintain blood pressure equally well" 03/01/2008 - "Administration of HDACI after hemorrhage (without fluid resuscitation) significantly improved survival (75% and 83% in VPA and SAHA groups, respectively, p < 0.05 vs. NR)" 01/01/2003 - "We also observed a significant reduction of the diameter of mesenteric terminal arterioles (15-30 microm) after bleeding, which was reversed temporarily in IS, BL, and HES groups, whereas resuscitation with HES 7.5 solution was able to maintain arterioles dilated until the end of the experimental period" Order ALL the reference details at left...
4.	Transplants (Transplant) 04/01/1991 - "Of the remaining 15 patients in complete remission (CR), four died from GVHD, hemorrhage and graft failure, and two relapsed at 7 and 54 months after BMT and died" 07/01/2004 - "CONCLUSION: Patients with chronic hepatic disease awaiting liver transplant can be treated successfully with endoscopic sinus surgery, but significant perioperative bleeding may not be avoidable" 12/01/2000 - "Children with heart or heart-lung transplants had significantly greater numbers of enamel defects and more gingival enlargement than control children, children in the heart transplant group had significantly more gingival bleeding" 11/01/2002 - "In aspect of operation time and bleeding volume, tissue engineered bone graft is superior to autogeneic iliac bone." 08/01/1977 - "All aneurysmal tissue from the aortic annulus to the innominate artery is excluded, bleeding through the graft is eliminated, operative time is reduced, and the late results have been satisfactory to date." Order ALL the reference details at left...
5.	Lasers (Laser) 08/01/1982 - "In 86 patients with active, nonspurting bleeding, the laser was significantly better (p less than 0.001) at stopping the bleeding than conservative treatment in randomized controls, and there was a numerical although not significant reduction of the rate of bleeding recurrence and the necessity for surgery (both p less than 0.1)" 05/01/1986 - "A key question is whether or not the laser is superior to other less costly and more portable modalities for treating acute UGI bleeding" 10/01/1997 - "The evidence for efficacy of laser treatment of bleeding is greater than for any other endoscopic treatment method" 02/01/1991 - "Concerning non-surgical cases, two patients were effectively treated using laser endoscopy and EIS, without the occurrence of variceal bleeding" 01/01/1989 - "During acute bleeding laser treatment was effective in 95% (1, 3)" Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Hemorrhage

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 2879 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>