HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria)

A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
Also Known As:
Paroxysmal Nocturnal Hemoglobinuria; Paroxysmal Cold Hemoglobinuria; Hemoglobinuria, Paroxysmal; Marchiafava-Micheli Syndrome; Paroxysmal Hemoglobinuria, Cold; Paroxysmal Hemoglobinuria, Nocturnal; Cold Paroxysmal Hemoglobinuria; Hemoglobinuria, Cold Paroxysmal; Hemoglobinuria, Nocturnal Paroxysmal; Hemoglobinuria, Paroxysmal Cold; Hemoglobinuria, Paroxysmal Nocturnal; Marchiafava Micheli Syndrome; Nocturnal Paroxysmal Hemoglobinuria; Syndrome, Marchiafava-Micheli
Networked: 957 relevant articles (32 outcomes, 44 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Venous Thrombosis (Deep-Vein Thrombosis)
2. Reperfusion Injury
3. Hemolysis
4. Aplastic Anemia (Anemia, Hypoplastic)
5. Myelodysplastic Syndromes (Myelodysplastic Syndrome)

Experts

1. Brodsky, Robert A: 25 articles (12/2015 - 04/2004)
2. Risitano, Antonio M: 23 articles (12/2015 - 05/2002)
3. Hillmen, Peter: 20 articles (05/2014 - 05/2002)
4. Luzzatto, Lucio: 17 articles (02/2014 - 09/2002)
5. Young, Neal S: 16 articles (09/2014 - 05/2002)
6. Hill, Anita: 15 articles (09/2015 - 10/2005)
7. Notaro, Rosario: 13 articles (03/2014 - 09/2002)
8. Schrezenmeier, Hubert: 12 articles (09/2015 - 04/2003)
9. Kinoshita, Taroh: 12 articles (02/2014 - 02/2002)
10. Rother, Russell P: 12 articles (08/2010 - 02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paroxysmal Hemoglobinuria:
1. eculizumabFDA Link
2. Complement System Proteins (Complement)IBA
3. Granulocyte Colony-Stimulating Factor (G-CSF)IBA
4. Proteins (Proteins, Gene)IBA
5. Donath-Landsteiner antibodyIBA
6. Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
7. StreptokinaseFDA Link
8. thymidine 5'-triphosphate (TTP)IBA
9. Atypical hemolytic uremic syndromeIBA
10. Danazol (Azol)FDA LinkGeneric

Therapies and Procedures

1. Hematopoietic Stem Cell Transplantation
2. Transplants (Transplant)
3. Transplantation (Transplant Recipients)
4. Therapeutics
5. Thrombolytic Therapy