A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
Also Known As:
Paroxysmal Nocturnal Hemoglobinuria; Paroxysmal Cold Hemoglobinuria; Hemoglobinuria, Paroxysmal; Marchiafava-Micheli Syndrome; Paroxysmal Hemoglobinuria, Cold; Paroxysmal Hemoglobinuria, Nocturnal; Cold Paroxysmal Hemoglobinuria; Hemoglobinuria, Cold Paroxysmal; Hemoglobinuria, Nocturnal Paroxysmal; Hemoglobinuria, Paroxysmal Cold; Hemoglobinuria, Paroxysmal Nocturnal; Marchiafava Micheli Syndrome; Nocturnal Paroxysmal Hemoglobinuria; Syndrome, Marchiafava-Micheli