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Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria)

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701  relevant articles (18 outcomes, 35 trials/studies) found for this Disease

Description: A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.

Also Known As:
Paroxysmal Nocturnal Hemoglobinuria; Paroxysmal Cold Hemoglobinuria; Hemoglobinuria, Paroxysmal; Marchiafava-Micheli Syndrome; Paroxysmal Hemoglobinuria, Cold; Paroxysmal Hemoglobinuria, Nocturnal; Cold Paroxysmal Hemoglobinuria; Hemoglobinuria, Cold Paroxysmal; Hemoglobinuria, Nocturnal Paroxysmal; Hemoglobinuria, Paroxysmal Cold; Hemoglobinuria, Paroxysmal Nocturnal; Marchiafava Micheli Syndrome; Nocturnal Paroxysmal Hemoglobinuria; Syndrome, Marchiafava-Micheli

Relationship Network

Disease Context: Research Results

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Hemic and Lymphatic Diseases
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Hematologic Diseases: 1420
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Anemia: 15158
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Hemolytic Anemia: 3205
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Paroxysmal Hemoglobinuria: 701
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Bone Marrow Diseases: 60
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Myelodysplastic Syndromes: 3002
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Paroxysmal Hemoglobinuria: 701

Related Diseases

1. Venous Thrombosis (Deep-Vein Thrombosis)
2. Aplastic Anemia (Anemia, Hypoplastic)
3. Myelodysplastic Syndromes (Myelodysplastic Syndrome)
4. Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)
5. Membranous Glomerulonephritis (Membranous Nephropathy)

Experts

1. Rother, Russell P: 8 articles (02/2008 - 02/2004)
2. Brodsky, Robert A: 7 articles (04/2008 - 02/2006)
3. Hillmen, Peter: 7 articles (02/2008 - 11/2003)
4. Hill, Anita: 6 articles (07/2008 - 10/2005)
5. Luzzatto, Lucio: 5 articles (03/2008 - 10/2005)
6. Schubert, Jörg: 5 articles (02/2008 - 01/2002)
7. Rollins, Scott A: 5 articles (12/2007 - 02/2004)
8. Mojcik, Christopher F: 5 articles (12/2007 - 02/2004)
9. Liu, Hong: 5 articles (10/2005 - 02/2002)
10. Bai, Jie: 5 articles (10/2005 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paroxysmal Hemoglobinuria:
1. eculizumabFDA Link
2. Complement System Proteins (Complement)IBA
3. Donath-Landsteiner antibodyIBA
4. Granulocyte Colony-Stimulating Factor (G-CSF)IBA
5. Urinary Plasminogen Activator (Urokinase)FDA LinkGeneric
6. StreptokinaseFDA Link
7. Danazol (Azol)FDA LinkGeneric
8. Penicillins (Penicillin)FDA Link
9. Adrenocorticotropic Hormone (ACTH)FDA Link
10. Inosine Triphosphate (ITP)IBA

Therapies and Procedures

1. Transplants (Transplant)
2. Transplantation (Transplant Recipients)
3. Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
4. Bone Marrow Transplantation (Transplantation, Bone Marrow)
5. Drug Therapy (Chemotherapy)

Best Treatments:
Research Summary Report
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