Hemoglobin M

A group of abnormal hemoglobins in which amino acid substitutions take place in either the alpha or beta chains but near the heme iron. This results in facilitated oxidation of the hemoglobin to yield excess methemoglobin which leads to cyanosis.

Networked: 18 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jeon, Younghoon: 1 article (10/2021)
2.	Park, Youngje: 1 article (10/2021)
3.	Ri, Hyunsu: 1 article (10/2021)
4.	Baek, Hee Jo: 1 article (12/2020)
5.	Kim, Bo Ram: 1 article (12/2020)
6.	Kim, Dae Sung: 1 article (12/2020)
7.	Kook, Hoon: 1 article (12/2020)
8.	Lee, Jun Hyung: 1 article (12/2020)
9.	Yoon, Bo Ae: 1 article (12/2020)
10.	González, Fernando A: 1 article (07/2019)

Related Diseases

1.	Congenital Methemoglobinemia 01/01/1972 - "Congenital methemoglobinemia due to hemoglobin M." 01/01/2019 - "Hemoglobin M (Hb M) disease is one type of congenital methemoglobinemia characterized by cyanosis. " 06/01/2008 - "Hemoglobin M variant and congenital methemoglobinemia: methylene blue will not be effective in the presence of hemoglobin M." 02/01/2008 - "Hemoglobin M variant and congenital methemoglobinemia: methylene blue will not be effective in the presence of hemoglobin M." 10/01/2021 - "Anesthetic experience: congenital methemoglobinemia due to hemoglobin M."
2.	Cyanosis 09/16/2022 - "However, upon arrival of the presumed biological father, a thorough history revealed an extensive paternal family history of neonatal cyanosis due to a rare mutation resulting in a hemoglobin M variant. " 03/01/1990 - "[Hereditary cyanosis caused by the presence of abnormal hemoglobin M in the blood: its detection, identification and properties]." 07/01/1975 - "Report on a further hemoglobin M variant, discovered in a boy with congenital cyanosis. " 03/01/1961 - "[Biological diagnosis of cyanoses and detection of hemoglobin M]." 03/01/1958 - "[Congenital cardiac defect with cyanosis caused by pathological blood pigment (hemoglobin M)]."
3.	Methemoglobinemia 12/01/2020 - "The First Korean Family with Hemoglobin-M Milwaukee-2 Leading to Hereditary Methemoglobinemia." 08/01/2003 - "A normal newborn screen and hemoglobin electrophoresis made the diagnosis of hemoglobin M unlikely as the cause of the methemoglobinemia (Hb A 59.4%, A2 1.8%, and F 38.8%). " 05/01/2000 - "Dominant hereditary methemoglobinemia (hemoglobin M diseases) is due to punctual mutations on the alpha or beta globin chain leading to its permanent oxidation. " 01/01/1988 - "Known etiologies of methemoglobinemia such as oxidative drug exposure, deficiency of NADH-methemoglobin reductase, and hemoglobin M disorder were excluded. " 01/01/1981 - "Toxic methemoglobinemia, methemoglobinemia due to hemoglobin M's, and hereditary methemoglobinemia due to deficiency in NADH-methemoglobin reductase activity are considered. "
4.	Hemoglobinopathies 07/01/2019 - "Regarding structural hemoglobinopathies, there were only 2 cases of hemoglobinopathies with low oxygen affinity and 1 case of hemoglobin M; the remaining 150 were silent hemoglobinopathies. "
5.	Hemolytic Anemia 12/01/2020 - "Hemoglobin M (HbM) is a group of abnormal hemoglobin variants that form methemoglobin, which leads to cyanosis and hemolytic anemia. "

Related Drugs and Biologics

1.	Methylene Blue (Methylthioninium Chloride)
2.	Methemoglobin
3.	Hemoglobins (Hemoglobin)
4.	Cytochrome-B(5) Reductase (Methemoglobin Reductase)
5.	Cytochromes b5 (Cytochrome b5)
6.	Oxidoreductases (Dehydrogenase)
7.	beta-Globins (beta Globin)
8.	Oxidants (Oxidizing Agents)
9.	Oxygen (Dioxygen)
10.	Anesthetics (Anesthetic Agents)