Hemocyanins

Metalloproteins that function as oxygen transport proteins in the HEMOLYMPH of MOLLUSKS and ARTHROPODS. They are characterized by two copper atoms, coordinated with HISTIDINE residues, that reversibly bind a single oxygen molecule; they do not contain HEME groups.

Also Known As:

Networked: 155 relevant articles (7 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Yueling: 11 articles (01/2022 - 08/2009)
2.	Becker, María Inés: 11 articles (01/2020 - 12/2006)
3.	Aweya, Jude Juventus: 7 articles (01/2022 - 01/2017)
4.	Del Campo, Miguel: 7 articles (01/2019 - 03/2009)
5.	Wang, Fan: 6 articles (01/2022 - 09/2016)
6.	Dolashka, Pavlina: 6 articles (07/2020 - 01/2011)
7.	Manubens, Augusto: 6 articles (12/2019 - 03/2009)
8.	Zhong, Mingqi: 6 articles (01/2019 - 07/2013)
9.	Idakieva, Krassimira: 5 articles (06/2022 - 03/2013)
10.	Zheng, Zhou: 5 articles (01/2022 - 01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "The biodiversity of hemocyanins has promoted interest in identifying new anti-cancer candidates with improved immunological properties. " 08/01/1990 - "However, in vivo depletion of L3T4+ or Lyt-2+ cells from 38C-Id-keyhole limpet hemocyanin-immunized mice resulted in diminished protection against a tumor challenge. " 05/26/2023 - "The present study indicated that the antitumor activity of the studied hemocyanins was due to both immune stimulation and direct effects on the tumor cells, and they displayed their potential as therapeutic agents against hematological malignances." 05/26/2023 - "The present study aims to assess the in vitro and in vivo anticancer activity of hemocyanins isolated from Helix aspersa, Helix lucorum, and Rapana venosa in the Graffi myeloid tumor model. " 01/01/2017 - "In this study we investigated the anti-tumor activity of hemocyanin from Litopenaeus vannamei on Sarcoma-180 (S180) tumor-bearing mice model. "
2.	Hypoxia (Hypoxemia) 11/01/2020 - "Hemocyanin and hexamerins expression in response to hypoxia in stoneflies (Plecoptera, Insecta)." 11/01/2016 - "The O2 saturation of arterial hemocyanin was 47% in severe hypoxia after 120 min, significantly lower than in normoxia (80%). " 06/01/2015 - "Respiratory Properties of Hemocyanin From Wild and Aquacultured Penaeid Shrimp and the Effects of Chronic Exposure to Hypoxia." 05/01/2010 - "Hemocyanin (Hcy) concentration did not explain these individual-level differences, however, hypoxia-tolerant crabs had Hcy structures indicative of a high-O(2)-affinity form of Hcy, suggesting Hcy "quality" (i.e., structure) may be more important for hypoxia survival than Hcy "quantity" (i.e., concentration). " 05/01/2010 - "Laboratory experiments coupled with molecular techniques determined how extrinsic factors (e.g., water body and temperature) and respiratory physiology (hemocyanin concentration and structure) affected survival and behavior of adult blue crabs (Callinectes sapidus) exposed to different levels of hypoxia over a 30-h time period. "
3.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2015 - "Together with the already known immunogenic effect, these findings support further studies on hemocyanins as potential therapeutic agents against bladder cancer." 03/01/2013 - "In vitro effect of molluscan hemocyanins on CAL-29 and T-24 bladder cancer cell lines." 03/01/2009 - "Here we investigated the individual contribution of CCHA and CCHB subunits from Concholepas hemocyanin (CCH) to in vivo humoral immune response and their pre-clinical evaluation as immunotherapeutic agent in a mice bladder cancer model, in relation to their biochemical properties. " 12/01/2006 - "Therefore, Concholepas concholepas hemocyanin may be an alternative candidate for providing safe and effective immunotherapy for human superficial bladder cancer." 01/01/2015 - "We evaluated the viability of 647-V, T-24, and CAL-29 bladder cancer cell lines after treatment with the tested hemocyanins. "
4.	Seasonal Allergic Rhinitis (Hay Fever) 07/01/2002 - "Immunotherapy with keyhole lampet hemocyanin-conjugated decapeptide vaccine in cypress pollen allergy." 07/01/2002 - "A randomized, double-blind, placebo-controlled trial was carried out to assess the efficacy of a vaccine made of keyhole lampet hemocyanin (KLH)-conjugated decapeptide from the Fc(epsilon4) domain of the IgE in cypress pollinosis. "
5.	Infections 10/01/2015 - "Together, these studies suggested that hemocyanin variant, LvHMCV4, might be involved in shrimp resistance to pathogenic infection." 07/01/2013 - "In summary, these studies suggested a novel splicing variant of hemocyanin in shrimp, which might be involved in shrimp resistance to pathogenic infection." 10/26/2023 - "However, the regulation of hemocyanin gene expression in shrimp hemocytes and the mechanisms involved during pathogen infection remains unclear. " 10/26/2023 - "The Yin Yang 1 of Penaeus vannamei regulates transcription of the small subunit hemocyanin gene during Vibrio parahaemolyticus infection." 10/01/2019 - "Effects of Vibro harveyi and Staphyloccocus aureus infection on hemocyanin synthesis and innate immune responses in white shrimp Litopenaeus vannamei."

Related Drugs and Biologics

1.	Vaccines
2.	Immunoglobulin E (IgE)
3.	Antioxidants
4.	saponin QA-21V1 (QS21)
5.	Oxygen (Dioxygen)
6.	Addavax
7.	Superoxide Dismutase
8.	Malondialdehyde (Propanedial)
9.	aluminum sulfate (alum)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Aftercare (After-Treatment)
4.	Intraperitoneal Injections