|1.||Idakieva, Krassimira: 5 articles (01/2016 - 01/2011)|
|2.||Becker, María Inés: 5 articles (01/2014 - 12/2006)|
|3.||Dolashka, Pavlina: 4 articles (06/2015 - 01/2011)|
|4.||Moltedo, Bruno: 4 articles (01/2014 - 12/2006)|
|5.||Del Campo, Miguel: 4 articles (01/2014 - 03/2009)|
|6.||De Ioannes, Pablo: 4 articles (01/2014 - 12/2006)|
|7.||Zhang, Yueling: 3 articles (10/2015 - 08/2009)|
|8.||Zhao, Xianliang: 3 articles (10/2015 - 08/2009)|
|9.||Stevanovic, Stefan: 3 articles (06/2015 - 07/2014)|
|10.||Tchorbanov, Andrey: 3 articles (05/2015 - 01/2011)|
01/01/2014 - "The biodiversity of hemocyanins has promoted interest in identifying new anti-cancer candidates with improved immunological properties. "
08/01/1990 - "However, in vivo depletion of L3T4+ or Lyt-2+ cells from 38C-Id-keyhole limpet hemocyanin-immunized mice resulted in diminished protection against a tumor challenge. "
01/01/2014 - "KLH (Megathura crenulata hemocyanin) is the most studied molecule of this group setting a standard for natural carrier protein for small molecules and has been used in anti-tumor clinical trials. "
06/01/2015 - "RETRACTED ARTICLE: Structure and characterization of cancer pagurus hemocyanin."
01/01/2014 - "Altogether, our data demonstrate that FLH possesses increased anti-tumor activity in part because it activates a more potent innate immune response in comparison to other known hemocyanins. "
|2.||Urinary Bladder Neoplasms (Bladder Cancer)
01/01/2015 - "Together with the already known immunogenic effect, these findings support further studies on hemocyanins as potential therapeutic agents against bladder cancer."
03/01/2009 - "Here we investigated the individual contribution of CCHA and CCHB subunits from Concholepas hemocyanin (CCH) to in vivo humoral immune response and their pre-clinical evaluation as immunotherapeutic agent in a mice bladder cancer model, in relation to their biochemical properties. "
12/01/2006 - "Therefore, Concholepas concholepas hemocyanin may be an alternative candidate for providing safe and effective immunotherapy for human superficial bladder cancer."
01/01/2015 - "We evaluated the viability of 647-V, T-24, and CAL-29 bladder cancer cell lines after treatment with the tested hemocyanins. "
01/01/2015 - "Changes in the gene expression profile of the bladder cancer cell lines after treatment with Helix lucorum and Rapana venosa hemocyanin."
|3.||Seasonal Allergic Rhinitis (Hay Fever)
07/01/2002 - "Immunotherapy with keyhole lampet hemocyanin-conjugated decapeptide vaccine in cypress pollen allergy."
07/01/2002 - "A randomized, double-blind, placebo-controlled trial was carried out to assess the efficacy of a vaccine made of keyhole lampet hemocyanin (KLH)-conjugated decapeptide from the Fc(epsilon4) domain of the IgE in cypress pollinosis. "
10/01/2015 - "Together, these studies suggested that hemocyanin variant, LvHMCV4, might be involved in shrimp resistance to pathogenic infection."
07/01/2013 - "In summary, these studies suggested a novel splicing variant of hemocyanin in shrimp, which might be involved in shrimp resistance to pathogenic infection."
05/01/2009 - "To understand molecular immune response of Penaeus vannamei during Taura syndrome virus (TSV) infection, expression and functional proteomics studies were performed on hemocyanin, which is a major abundant protein in shrimp hemocytes. "
01/01/2008 - "In this study, we show that this protein complex could delay the infection of white spot syndrome virus (WSSV) in vivo and cloned two hemocyanin subunits genes (PjHcL and PjHcY) from the shrimp Penaeus japonicus. "
01/01/2015 - "Characterization of hemocyanin from the mud crab Scylla paramamosain and its expression analysis in different tissues, at various stages, and under Vibrio parahaemolyticus infection."
01/25/2014 - "Immunohistochemistry analysis revealed, for the first time, hemocyanin protein expression as significant hypoxia-specific signature in prawns,which opens the way for in depth molecular studies of hypoxia exposure. "
06/01/2015 - "Respiratory Properties of Hemocyanin From Wild and Aquacultured Penaeid Shrimp and the Effects of Chronic Exposure to Hypoxia."
05/01/2010 - "Hemocyanin (Hcy) concentration did not explain these individual-level differences, however, hypoxia-tolerant crabs had Hcy structures indicative of a high-O(2)-affinity form of Hcy, suggesting Hcy "quality" (i.e., structure) may be more important for hypoxia survival than Hcy "quantity" (i.e., concentration). "
05/01/2010 - "Laboratory experiments coupled with molecular techniques determined how extrinsic factors (e.g., water body and temperature) and respiratory physiology (hemocyanin concentration and structure) affected survival and behavior of adult blue crabs (Callinectes sapidus) exposed to different levels of hypoxia over a 30-h time period. "
08/01/1994 - "The electrophoretic banding pattern of hemocyanin monomers in blue crabs caught in natural waters indicate that the phenotypes associated with normoxia or hypoxia in the laboratory can also be found in those conditions in nature. "
|1.||Immunoglobulin E (IgE)
|3.||Proteins (Proteins, Gene)
|4.||Immunoglobulin G (IgG)
|7.||Immunoglobulin A (IgA)
|8.||QS 21 (QS21)
|9.||14-3-3 Proteins (14-3-3 Protein)
|10.||Immunoglobulin M (IgM)