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Hemochromatosis (Bronze Diabetes)

A disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary. Full development of the disease in women is restricted by menstruation, pregnancy, and lower dietary intake of iron. Acquired hemochromatosis may be the result of blood transfusions, excessive dietary iron, or secondary to other disease. Idiopathic or genetic hemochromatosis is an autosomal recessive disorder of metabolism associated with a gene tightly linked to the A locus of the HLA complex on chromosome 6. (From Dorland, 27th ed)
Also Known As:
Bronze Diabetes; Hemochromatoses; Diabetes, Bronze
Networked: 2564 relevant articles (48 outcomes, 243 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Iron Overload
2. Anemia
3. Fibrosis (Cirrhosis)
4. End Stage Liver Disease
5. Sideroblastic Anemia

Experts

1. Barton, James C: 51 articles (12/2015 - 10/2002)
2. Adams, Paul C: 42 articles (08/2015 - 07/2002)
3. Acton, Ronald T: 36 articles (12/2015 - 10/2002)
4. Ganz, Tomas: 32 articles (02/2015 - 10/2002)
5. McLaren, Christine E: 31 articles (08/2015 - 02/2003)
6. Nemeth, Elizabeta: 27 articles (02/2015 - 02/2005)
7. Olynyk, John K: 26 articles (04/2015 - 04/2002)
8. McLaren, Gordon D: 25 articles (08/2015 - 02/2003)
9. Pietrangelo, Antonello: 23 articles (10/2015 - 03/2002)
10. Powell, Lawrie W: 22 articles (08/2015 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemochromatosis:
1. IronIBA
2. Ferritins (Ferritin)IBA
3. Transferrin (beta 2 Transferrin)IBA
4. hepcidinIBA
5. Deferoxamine (Desferal)FDA LinkGeneric
6. Messenger RNA (mRNA)IBA
7. Glucose (Dextrose)FDA LinkGeneric
8. Ribavirin (Virazole)FDA LinkGeneric
9. metal transporting protein 1 (ferroportin)IBA
10. Heme (Haem)IBA

Therapies and Procedures

1. Chelation Therapy (Therapy, Chelation)
2. Liver Transplantation
3. Renal Dialysis (Hemodialysis)
4. Blood Transfusion (Blood Transfusions)
5. Heart Transplantation (Grafting, Heart)