|1.||Ndisang, Joseph Fomusi: 18 articles (01/2015 - 06/2008)|
|2.||Jadhav, Ashok: 15 articles (01/2014 - 06/2008)|
|3.||Liu, Zai-Qun: 8 articles (07/2011 - 02/2008)|
|4.||Regan, Raymond F: 7 articles (10/2014 - 07/2003)|
|5.||Desnick, Robert J: 5 articles (01/2015 - 03/2005)|
|6.||Egan, Timothy J: 4 articles (04/2015 - 05/2006)|
|7.||Balwani, Manisha: 4 articles (01/2015 - 08/2011)|
|8.||Tiwari, Shuchita: 4 articles (01/2015 - 01/2013)|
|9.||Bishop, Glenda M: 4 articles (04/2014 - 01/2009)|
|10.||Robinson, Stephen R: 4 articles (04/2014 - 01/2009)|
|1.||Acute Intermittent Porphyria (Porphyria, Acute)
01/01/2011 - "The patient had a family history of acute intermittent porphyria (AIP) so we decided to begin treatment with hematin, achieving a complete remission of the symptoms. "
10/01/1988 - "Although hematin is frequently effective in the treatment of acute porphyria crises, it is often associated with abnormalities in coagulation and these effects also occur in normal volunteers."
02/01/1983 - "Hematin is clinically useful in the treatment of acute intermittent porphyria. "
12/01/1981 - "Hematin has been shown to be effective therapy for acute intermittent porphyria. "
02/01/1988 - "The efficacy of hematin has been evaluated in eight patients with acute intermittent porphyria: six with acute attacks and two with chronic subacute symptoms. "
11/01/2014 - "Moreover, since RBC components, especially those with long-term storage, contained sufficient hemin concentration to induce NETs, special attention to hemolysis of stored RBC components is important."
11/01/2013 - "Infusion of a low dose of hemin caused acute intravascular hemolysis and autoamplification of extracellular hemin in transgenic sickle mice, but not in sickle-trait littermates. "
11/01/2013 - "We tested the hypothesis that the hemolysis byproduct hemin elicits events that induce ACS. "
12/01/2009 - "CAP can also protect erythrocytes against hemin-induced hemolysis."
10/01/2009 - "AM1 or AP4b is not hemolytic per se and is less hemolytic than CQ when hemolysis is accelerated (induced) by hematin. "
01/01/2014 - "The present study examined whether hemin could prevent the development of high-fat diet-induced insulin resistance in the liver and skeletal muscle using a hyperinsulinemic-euglycemic clamp. "
01/01/2014 - "These results suggest that hemin prevents the development of high-fat diet-induced insulin resistance by increased insulin sensitivity in the skeletal muscle. "
01/01/2013 - "Contrarily, the HO-inhibitor, stannous mesoporphyrin nullified the hemin effect, exacerbating inflammatory/oxidative insults and aggravated insulin resistance (HOMA-index). "
06/01/2009 - "Correspondingly, ip glucose tolerance, insulin tolerance, and homeostasis model assessment insulin resistance analyses revealed improved glucose tolerance, reduced insulin intolerance, enhanced insulin sensitivity, and reduced insulin resistance in hemin-treated GK rats. "
05/01/2009 - "Correspondingly, hemin improved ip glucose tolerance, reduced insulin intolerance, and lowered insulin resistance (homeostasis model assessment of insulin resistance), and the inability of insulin to enhance GLUT4 was overturned. "
11/01/2004 - "We found that treatment with hemin led to a significant reduction of proteinuria and remarkable amelioration of glomerular lesions accompanied by decreased immune depositions. "
03/01/2000 - "In contrast, the administration of hemin, an HO inducer, ameliorated the Ang II-induced decrease in GFR (2.4+/-0.2 mL/min) and increase in proteinuria (9.3+/-4.5 mg/d). "
12/01/1999 - "The beneficial effect of hemin treatment on proteinuria could be linked to downregulation of iNOS."
12/01/1999 - "iNOS activity in glomeruli was significantly reduced in hemin-treated nephritic animals in which proteinuria was also attenuated without a change in monocyte/macrophage infiltration. "
03/01/1998 - "In ANTN proteinuria was reduced at day 1 and day 4 (36 +/- 11 vs. 60 +/- 15 and 36 +/- 7 vs. 86 +/- 9 mg protein/24 hr, respectively, P < 0.001), glomerular thrombi were reduced by hemin at day 1 and 4 (1.5 +/- 2.7 vs. 2.7 +/- 0.2 and 1.3 +/- 0.01 vs. 2.9 +/- 0.02, respectively, P < 0.001) and glomerular macrophage infiltration was reduced on day 4 (11.2 +/- 0.8 cells/glom; control 15.9 +/- 0.8, P < 0.01). "
04/21/2015 - "Despite numerous studies of malaria pathophysiology, fundamental questions regarding hematin growth and inhibition remain. "
12/01/2015 - "Ten of the Malaria Box compounds demonstrated significant inhibition of β-hematin formation. "
12/01/2015 - "Identification of β-hematin inhibitors in the MMV Malaria Box."
11/01/2015 - "The malaria parasite blocks hematin-induced lysis by biocrystallization, a process that converts hematin into insoluble and chemically inert crystals. "
11/07/2013 - "Therefore, this work demonstrates experimentally and theoretically the potential of tuning the core-shell Fe3O4@Ag for achieving the efficient magnetic field-enriched SERRS detection of β-hematin for early malaria diagnosis. "
|4.||Heme Oxygenase (Decyclizing) (Heme Oxygenase)
|6.||tin protoporphyrin IX
|7.||Glutathione (Reduced Glutathione)
|8.||Interleukin-10 (Interleukin 10)
|2.||Drug Therapy (Chemotherapy)