Hemicholinium 3

A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
Also Known As:
Hemicholinium; Morpholinium, 2,2'-(1,1'-biphenyl)-4,4'-diylbis(2-hydroxy-4,4-dimethyl)-, dibromide
Networked: 28 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Lau, Helene: 1 article (10/2014)
2. Klein, Jochen: 1 article (10/2014)
3. Zimmermann, Martina: 1 article (10/2014)
4. Weinfurter, Stefanie: 1 article (10/2014)
5. Imran, Imran: 1 article (10/2014)
6. Hillert, Markus H: 1 article (10/2014)
7. Simon, Jay R: 1 article (11/2009)
8. Ray, Balmiki: 1 article (11/2009)
9. Lahiri, Debomoy K: 1 article (11/2009)
10. Hara, Toshihiko: 1 article (10/2006)

Related Diseases

1. Amnesia (Dissociative Amnesia)
2. Hemorrhagic Shock
3. Seizures (Seizure)
4. Ganglion Cysts (Ganglion)
10/01/1977 - "Changes in A and N in the ganglion during peripheral reflexes are increased after prolonged action of hemicholinium and chronic decentralisation of CMG."
10/01/1977 - "Hemicholinium as well as N--cholinoblocking agents, during first minutes of their application to the ganglion elicit A and N release both before and after preganglionic fiber degeneration, which indicates their postsynaptic effect on the cholinoreceptors. "
05/01/1974 - "The ganglion's ACh store was labelled by perfusion, during preganglionic nerve stimulation, with Krebs solution containing [(3)H]choline.2. Preganglionic stimulation (5 Hz for 20 min) of ganglia containing [(3)H]ACh released similar amounts of radioactivity when perfusion was with neostigmine-choline-Krebs or with hemicholinium-Krebs. "
03/01/1972 - "As the stimulus was increased, the EPSP increased linearly with the amplitude of the presynaptic response.4. After replacement of potassium ions in the bathing solution by caesium and during the early phase of post-tetanic facilitation there was an increase in the presynaptic response accompanied by a disproportionate increase in the EPSP.5. No changes in the presynaptic response were found in the presence of the following drugs, all of which depressed the EPSP: acetylcholine, hemicholinium, curare, further doses of ganglion-blocking agents, and high Mg(2+) and low Ca(2+) concentrations.6. Ouabain (4.5 x 10(-4)M) reversibly decreased the amplitude of the presynaptic response and increased the spontaneous release of transmitter. "
5. Alzheimer Disease (Alzheimer's Disease)

Related Drugs and Biologics

1. Vasopressins (Vasopressin)
2. Deamino Arginine Vasopressin (Desmopressin)
3. Atropine (Hyoscyamine)
4. Reserpine (Serpasil)
5. Morphine (MS Contin)
6. Yohimbine (Yocon)
7. Adrenergic Receptors (Adrenergic Receptor)
8. Prazosin (Minipress)
9. Practolol
10. Guanethidine

Related Therapies and Procedures

1. Vagotomy
2. Splenectomy
3. Ligation
4. Adrenalectomy
5. Injections