Helium

A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics.

Also Known As:

Networked: 1416 relevant articles (70 outcomes, 184 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Preckel, Benedikt: 13 articles (12/2019 - 11/2008)
2.	Weber, Nina C: 9 articles (12/2019 - 11/2008)
3.	Debus, Jürgen: 8 articles (10/2022 - 08/2016)
4.	Mairani, Andrea: 8 articles (10/2022 - 08/2016)
5.	Tessonnier, Thomas: 8 articles (10/2022 - 04/2016)
6.	Hollmann, Markus W: 8 articles (01/2019 - 11/2008)
7.	McCormack, David G: 7 articles (01/2020 - 07/2010)
8.	Parraga, Grace: 7 articles (01/2020 - 07/2010)
9.	Jolliet, Philippe: 7 articles (12/2017 - 02/2003)
10.	Jacobi, C A: 7 articles (10/2005 - 01/2000)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2003 - "After exposure of neoplastic tissue to helium, a significant reduction of tumor growth has been detected in experimental studies, both in vitro and in vivo. " 08/01/2023 - "This study explored and demonstrated the possibilities of the Geant4-DNA toolkit together with the "molecularDNA" example to simulate the helium beam irradiation of cancer cell lines, to quantify the early DNA damage, or even the following DNA damage response." 08/01/2004 - "The objective of this study is to assess tumor growth after air and helium insufflation at different pressures. " 01/01/1999 - "These studies have demonstrated that the use of helium as a laparoscopic insufflation agent for cancer surgery results in less tumour implantation and growth at port sites. " 11/01/1998 - "In this study, helium was associated with reduced tumor growth."
2.	Chronic Obstructive Pulmonary Disease (COPD) 10/01/2022 - "[Is helium beneficial in a pulmonary rehabilitation program for severe COPD?]" 11/01/2021 - "This study evaluates role of hyperpolarized 3 helium (3 He) MRI measured apparent diffusion coefficient (ADC) in examining pulmonary function of chronic obstructive pulmonary disease (COPD) patients. " 07/06/2011 - "One study reported a helium-induced beneficial effect on surrogates of work of breathing after extubation in non-COPD patients, possibly in relation to laryngeal consequences of tracheal intubation. " 01/01/2010 - "Despite small trends favoring helium, this study did not show a statistical superiority of using helium during NIV to decrease the intubation rate in acute exacerbation of chronic obstructive pulmonary disease." 04/01/1989 - "To study this effect in patients, we measured functional residual capacity (FRC) by helium dilution at rest and during low-load supine exercise in 30 patients with chronic obstructive pulmonary disease. "
3.	Pneumoperitoneum 05/01/2008 - "Helium ameliorates renal alterations when used for pneumoperitoneum, and it might be used for patients with compromised renal function who have to undergo laparoscopic surgery." 12/01/2006 - "Improved abdominal wall wound healing by helium pneumoperitoneum." 02/01/2008 - "In this study a method for monitoring peritoneal pH during laparoscopy was evaluated and peritoneal pH during CO(2) and helium pneumoperitoneum was studied as well as its systemic reflection in arterial pH. For these experiments 20 pigs were used, with ten exposed to pneumoperitoneum with CO(2), and ten to helium. " 01/01/2005 - "The aim of this study was to investigate the effect of CO2 and helium pneumoperitoneum on the recovery of postoperative gastrointestinal motility. " 09/01/2002 - "For this study, 30 male WAG/Rij rats were randomized into two groups to obtain pneumoperitoneum with CO2 (n=15) or helium (n = 15). "
4.	Airway Obstruction (Choking) 04/01/1976 - "There was a significant correlation between the severity of airway obstruction as measured by V50 and the response to helium, both during remission and during induced bronchoconstriction; however, there was no correlation between helium response and specific airway conductance. " 01/01/2016 - "Helium was discovered in 1868 by the French astronomer Pierre-Jules-César Janssen and was first used as a therapeutic treatment for airway obstruction by Barach almost 70 years later, in 1934. " 12/04/2000 - "Since 1934 several clinical trials have been performed to investigate the effect of helium in the symptomatic treatment of upper and lower airway obstructions, especially in children. " 07/01/1990 - "This study investigates the effect of helium concentration in inspired gas on resistance to breathing during experimental upper airway obstruction. " 12/19/2019 - "Clinically, the noble gas helium is used in treatment of airway obstruction and ventilation disorders in children and adults. "
5.	Dyspnea (Shortness of Breath) 01/01/1986 - "This entity of upper airway dysfunction was responsible for, or at least contributed to, the respiratory symptoms as evidenced by dramatic relief of dyspnea following tracheostomy in one patient, and significant improvement of flow rates following helium breathing in the other 2 patients. " 05/01/2011 - "Moreover, helium:oxygen more potently improved systolic pressure, mean arterial pressure, pulse rate, respiratory rate, and dyspnea (P values: .012, .048, <.001, <.001, and .012, respectively). " 05/01/2019 - "Dyspnea was significantly reduced by HELIOX-containing mixtures with a fraction of helium of 25% or more. " 05/01/2019 - "Here, we investigate whether HELIOX with less than 60% of Helium is able to relieve the sensation of dyspnea in healthy volunteers. " 05/01/2011 - "Both air:oxygen and helium:oxygen significantly decreased systolic blood pressure, diastolic blood pressure, mean arterial pressure, pulse rate, respiratory rate, dyspnea, and increased oxygen saturation (P values: .007, .029, .002, <.001, <.001, <.001, and .002 for air:oxygen, respectively, and <.001, .020, .001, <.001, <.001, <.001, and .002, for helium:oxygen, respectively). "

Related Drugs and Biologics

1.	Oxygen (Dioxygen)
2.	Argon
3.	Ions
4.	heliox
5.	Xenon
6.	Protons (Proton)
7.	Gases
8.	Carbon
9.	Nitrogen
10.	Noble Gases (Rare Gases)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Cryosurgery
3.	Therapeutics
4.	Radiotherapy
5.	Laser Therapy (Surgery, Laser)