HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Heavy Chain Disease

A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
Also Known As:
Franklin's Disease; Franklins Disease; Heavy Chain Diseases; gamma Chain Disease; gamma-Chain Diseases; mu Chain Disease; mu-Chain Diseases; Franklin Disease; gamma-Chain Disease; mu-Chain Disease
Networked: 190 relevant articles (3 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Lymphoma (Lymphomas)
2. Neoplasms (Cancer)
3. Waldenstrom Macroglobulinemia (Macroglobulinemia)
4. Immunoproliferative Small Intestinal Disease
5. Carcinogenesis

Experts

1. Takahashi, Takayuki: 5 articles (09/2019 - 09/2003)
2. Morita, Keiko: 3 articles (03/2006 - 09/2002)
3. Okamoto, Yasuyuki: 3 articles (03/2006 - 09/2002)
4. Aoyama, Yumi: 2 articles (09/2019 - 01/2019)
5. Kodaka, Taiichi: 2 articles (09/2019 - 01/2019)
6. Sasaki, Miho: 2 articles (09/2019 - 01/2019)
7. Tsunemine, Hiroko: 2 articles (09/2019 - 01/2019)
8. Zushi, Yuriko: 2 articles (09/2019 - 01/2019)
9. Tamura, Akiyo: 2 articles (01/2019 - 09/2003)
10. Kurimoto, Miwa: 2 articles (01/2016 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Heavy Chain Disease:
1. Prednisone (Sone)FDA LinkGeneric
2. Cyclophosphamide (Cytoxan)FDA LinkGeneric
3. Chlorambucil (Leukeran)FDA Link
4. Adrenal Cortex Hormones (Corticosteroids)IBA
5. Proteins (Proteins, Gene)FDA Link
6. Immunoglobulins (Immunoglobulin)IBA
7. Immunoglobulin G (IgG)IBA
8. Immunoglobulin A (IgA)IBA
9. Immunoglobulin Fc FragmentsIBA
10. gamma-Globulins (gamma-Globulin)IBA

Therapies and Procedures

1. Combination Drug Therapy (Combination Chemotherapy)
2. Radiotherapy
3. Therapeutics
4. Nutritional Support (Artificial Feeding)
5. Hematopoietic Stem Cell Transplantation