Heartwater Disease

A tick-borne septicemic disease of domestic and wild ruminants caused by EHRLICHIA RUMINANTIUM.

Also Known As:

Disease, Heartwater

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Infections: 526564
- Vector Borne Diseases: 374
  - Tick-Borne Diseases: 496
    - Ehrlichiosis: 446
      - Heartwater Disease: 12
- Bacterial Infections and Mycoses: 1
  - Bacterial Infections: 24368
    - Gram-Negative Bacterial Infections: 918
      - Anaplasmataceae Infections: 12
        Ehrlichiosis: 446
        Heartwater Disease: 12
Animal Diseases: 416
- Heartwater Disease: 12

Related Diseases

1.	Weight Loss (Weight Reduction)
2.	Infections
3.	Hypertension (High Blood Pressure)

Experts

1.	Afolayan, Anthony Jide: 1 article (01/2018)
2.	Otunola, Gloria Aderonke: 1 article (01/2018)
3.	Unuofin, Jeremiah Oshiomame: 1 article (01/2018)
4.	Barbet, Anthony F: 1 article (06/2009)
5.	Byrom, Barbara: 1 article (06/2009)
6.	Mahan, Suman M: 1 article (06/2009)
7.	French, Jeffrey O: 1 article (01/2007)
8.	Hughes, Austin L: 1 article (01/2007)
9.	Esteves, Isabel: 1 article (03/2004)
10.	Letesson, Jean-Jacques: 1 article (03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Heartwater Disease:

1.	Attenuated VaccinesIBA 01/01/1994 - "[Field trial of an attenuated vaccine against heartwater disease]."
2.	Proteins (Proteins, Gene)FDA Link 06/01/2009 - "Proteins expressed from the map1 multigene family of Ehrlichia ruminantium are strongly recognized by immune T and B cells from infected animals or from animals that were infected and have recovered from heartwater disease (although still remaining infected carriers). " 04/01/1994 - "Cowdria ruminatium, the causative agent of heartwater disease, expresses an immunodominant and conserved 32-kilodalton protein (MAP1; formerly called Cr32), which is currently in use for serodiagnosis of the disease. "
3.	AntigensIBA 01/01/1990 - "[Comparison between 3 antigens for the serodiagnosis of heartwater disease by indirect immunofluorescence]." 12/01/1986 - "Detection of Cowdria ruminantium antigen and antibody during the course of heartwater disease in sheep by means of an enzyme-linked immunosorbent assay."
4.	AntibodiesIBA 09/01/1987 - "An ELISA was used to detect Cowdria ruminantium antibodies during the course of heartwater disease. " 12/01/1986 - "An enzyme-linked immunosorbent assay was used to detect Cowdria ruminantium antibodies during the course of heartwater disease. "
5.	DNA ProbesIBA 04/01/2000 - "We have previously reported that the pCS20 PCR detection assay for Cowdria ruminantium, the causative agent of heartwater disease of ruminants, is more sensitive than xenodiagnosis and the pCS20 DNA probe for the detection of infection in the vector Amblyomma ticks. "
6.	NucleotidesIBA 01/31/2007 - "Patterns of nucleotide substitution at orthologous loci were examined between three genomes of Ehrlichia ruminantium, the causative agent of heartwater disease of ruminants. "
7.	Interferon-gamma (Interferon, gamma)IBA 03/01/2004 - "Interferon gamma (IFN-gamma) is considered as a key mediator of protective cell-mediated immunity against intracellular pathogens in general, and against Ehrlichia ruminantium, the causative agent of tick-borne heartwater disease of ruminants, in particular. "
8.	ImmunosorbentsIBA 12/01/1986 - "An enzyme-linked immunosorbent assay was used to detect Cowdria ruminantium antibodies during the course of heartwater disease. " 12/01/1986 - "Detection of Cowdria ruminantium antigen and antibody during the course of heartwater disease in sheep by means of an enzyme-linked immunosorbent assay."
9.	EnzymesIBA 12/01/1986 - "An enzyme-linked immunosorbent assay was used to detect Cowdria ruminantium antibodies during the course of heartwater disease. " 12/01/1986 - "Detection of Cowdria ruminantium antigen and antibody during the course of heartwater disease in sheep by means of an enzyme-linked immunosorbent assay."
10.	Ribosomal DNA (rDNA)IBA 07/01/1992 - "The 16S ribosomal DNA sequence of Cowdria ruminantium, the causative agent of heartwater disease in ruminants, was determined. "

Therapies and Procedures

1.	African Traditional Medicine (Medicine, African) 01/01/2018 - "is a shrub of the Asteraceae family used in the South African traditional medicine system for the management of weight loss, hypertension, and heartwater disease. "