HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Heartburn (Pyrosis)

Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.
Also Known As:
Pyrosis; Pyroses
Networked: 1048 relevant articles (206 outcomes, 156 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Gastroesophageal Reflux (GERD)
2. Pain (Aches)
3. Esophagitis
4. Nausea
5. Eructation (Eructations)

Experts

1. Fass, Ronnie: 11 articles (07/2015 - 05/2005)
2. Fass, R: 10 articles (05/2014 - 12/2000)
3. Miner, P B: 10 articles (04/2010 - 01/2000)
4. Robinson, M: 10 articles (11/2003 - 01/2000)
5. Savarino, Edoardo: 9 articles (01/2016 - 11/2006)
6. Savarino, Vincenzo: 9 articles (01/2016 - 11/2006)
7. Watson, David I: 9 articles (09/2015 - 11/2004)
8. Devitt, Peter G: 9 articles (09/2015 - 11/2004)
9. Jamieson, Glyn G: 9 articles (09/2015 - 11/2004)
10. Johnson, David A: 9 articles (02/2015 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Heartburn:
1. Omeprazole (Esomeprazole)FDA LinkGeneric
2. Ranitidine (Zantac)FDA LinkGeneric
3. lansoprazole (Prevacid)FDA LinkGeneric
4. rabeprazole (Aciphex)FDA Link
5. AntacidsIBA
6. pantoprazole (Protonix)FDA LinkGeneric
7. Proton Pump InhibitorsIBA
8. Cisapride (Propulsid)FDA Link
9. Cimetidine (Biomet)FDA LinkGeneric
10. Nizatidine (Axid)FDA LinkGeneric

Therapies and Procedures

1. Fundoplication
08/01/2007 - "After laparoscopic Nissen fundoplication, frequency and severity scores dramatically improved for all symptoms queried (P < 0.001), especially for heartburn frequency (8, 8 +/- 3.2 versus 2, 3 +/- 2.8, P < 0.001) and severity (10, 8 +/- 2.9 versus 1, 2 +/- 2.5, P < 0.001). "
10/01/2005 - "In our hands, a Nissen fundoplication with complete mobilization of the fundus yielded the best results, a Nissen-Rossetti operation had more disphagia and more reoperations and a partial fundoplication of Toupet, had a higher incidence of recurrent heartburn."
12/01/2001 - "Although all symptoms were improved by fundoplication, resolution was more likely for heartburn than for atypical symptoms. "
01/01/2008 - "Nissen fundoplication in refractory patients, either open or laparoscopic, was effective in control of heartburn in 95% of patients contrary to 50% in mixed symptoms."
01/01/2015 - " proportion of people with heartburn at short term (surgery: 29/288 (adjusted proportion = 10.0%); medical: 59/266 (22.2%); RR 0.45, 95% CI 0.30 to 0.69; participants = 554; studies = 1), medium term (surgery: 12/288 (adjusted proportion = 4.2%); medical: 59/266 (22.2%); RR 0.19, 95% CI 0.10 to 0.34; participants = 554; studies = 1), long term (surgery: 46/111 (adjusted proportion = 41.2%); medical: 78/106 (73.6%); RR 0.56, 95% CI 0.44 to 0.72); participants = 217; studies = 1) and those with reflux symptoms at short-term (surgery: 6/288 (adjusted proportion = 2.0%); medical: 53/266 (19.9%); RR 0.10, 95% CI 0.05 to 0.24; participants = 554; studies = 1) and medium term (surgery: 6/288 (adjusted proportion = 2.1%); medical: 37/266 (13.9%); RR 0.15, 95% CI 0.06 to 0.35; participants = 554; studies = 1) was less in the laparoscopic fundoplication group than in the medical treatment group. "
2. Aftercare (After-Treatment)
3. Self Medication
4. Gastrectomy
5. Gastric Bypass (Roux-en-Y Gastric Bypass)