Induced Heart Arrest (Cardioplegia)

A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).

Also Known As:

Networked: 2187 relevant articles (167 outcomes, 252 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Chambers, David J: 11 articles (01/2022 - 08/2002)
2.	Yeh, Chi-Hsiao: 10 articles (04/2013 - 05/2003)
3.	Chen, Wen-Jone: 9 articles (01/2022 - 07/2007)
4.	Huang, Chien-Hua: 9 articles (01/2022 - 07/2007)
5.	Tsai, Min-Shan: 9 articles (01/2022 - 07/2007)
6.	Sellke, Frank W: 9 articles (06/2017 - 08/2003)
7.	Lin, Yu-Min: 9 articles (04/2013 - 04/2005)
8.	Feng, Jun: 8 articles (06/2017 - 04/2002)
9.	Chen, Tzu-Ping: 8 articles (04/2013 - 05/2005)
10.	Bianchi, Cesario: 8 articles (01/2008 - 08/2003)

Related Diseases

1.	Ischemia 09/01/1998 - "The experimental results suggest that such interventions could be beneficial in clinical situations such as cardioplegia, heart preservation, or recovery from ischemia." 01/01/1997 - "Left ventricular developed pressure (LVDP) at 30 min reperfusion after unprotected ischemia was significantly improved by IPC, while the recovery of LVDP at 30 min reperfusion after cardioplegia was comparable between control and IPC-treated hearts. " 02/01/1996 - "A significant reduction in endothelium-dependent vascular function was observed after 40 minutes of ischemia (-31.8% +/- 6.6% vs -50.4% +/- 1.6% in control hearts, p < 0.05), and again this was improved by cardioplegia (-45.0% +/- 3.4%, p < 0.05 vs ischemic group). " 12/01/2003 - "Preconditioning with cardioplegia is more effective in reducing apoptosis than is preconditioning with ischemia in the human myocardium." 11/01/1994 - "With the continuing search for superior methods of myocardial protection, we compared the protective efficacy of ischemic preconditioning with that of St Thomas' cardioplegia, alone and in combination, against vascular and myocyte injury during ischemia and reperfusion. "
2.	Hypothermia 08/01/1992 - "The findings suggest that, even though no consensus exists about its ideal composition, cardioplegia in conjunction with hypothermia is currently the strategy most often used for pediatric myocardial protection." 01/01/1987 - "Cardioplegia is most effective when combined with the additive properties of hypothermia, which plays a significant role in decreasing myocardial metabolism. " 09/01/1996 - "In hypertrophied hearts, protection by topical hypothermia alone resulted in significantly improved postischemic recoveries of maximum left ventricular pressure and rate of pressure rise compared with the method of slow cooling or application of cardioplegia (40.6% +/- 5.0% and 38.1% +/- 5.9%, mean +/- standard error of the mean; p < 0.05). " 03/01/1983 - "The small increase in risk compared to the significant improvement from the combined approach has led to the following principles: coronary arteriography on all adult patients requiring valvular operations; bypass of all significant coronary lesions; restoration of valvular function and hemodynamics; and myocardial preservation with cold cardioplegia during a single period of cross clamping, topical cold, and systemic hypothermia." 12/01/1992 - "These techniques deviate from conventional practice, and they infer that normothermia is superior to hypothermia, retrograde cardioplegia is more advantageous than antegrade administration, and continuous cardioplegic delivery is preferable to intermittent dosage. "
3.	Reperfusion Injury 01/01/1990 - "The study shows that previously infarcted hearts are susceptible to ischemic damage even after 2 h of regular hypothermic, ischemic cardioplegia and that a gentle reperfusion technique significantly ameliorates reperfusion injury." 01/01/2006 - "Controlled cardiac reoxygenation, as an adjunct to substrate-enhanced cardioplegia, has been shown to improve myocardial function and limit reperfusion injury when utilizing standardized hyperoxic cardiopulmonary bypass (CPB). " 03/01/1995 - "[Efficacy of terminal warm blood cardioplegia against the reperfusion injury]." 05/30/2023 - "In this Hunterian lecture, I propose an evidence-based strategy to improve myocardial protection during cardiac surgery in children through: (1) conducting multicentre clinical trials of established techniques; (2) improving our knowledge of ischaemia/reperfusion injury in the setting of cardioplegic arrest; (3) applying this to drive innovation, moving beyond current cardioplegia solutions; (4) empowering personalised medicine, through combining clinical and genomic data, including ethnic diversity; and (5) understanding the impact of cardioplegic arrest on the late outcomes that matter to patients and their families." 12/20/2019 - "In this study, we aimed to assess myocardial protection and ischemia-reperfusion injury in patients undergoing open heart surgery with isothermic blood cardioplegia (IBC) or hypothermic blood cardioplegia (HBC). "
4.	Heart Arrest (Cardiac Arrest) 03/01/1976 - "Because of the significantly improved preservation of the fine structure of the heart and retardation of ischaemically provoked changes in cardiac metabolism, the method of inducing heart arrest by cardioplegia should also clinically be given preference to methods of arresting the heart by ischaemia." 01/01/2022 - "In this study, a porcine model of cardiopulmonary bypass was used to compare the protective effects of normothermic blood-based polarizing and depolarizing cardioplegia during cardiac arrest. " 07/01/2018 - "This study showed that cardiac arrest with Del Nido cardioplegia during intra cardiac repair for TOF was associated with improved myocardial protection over standard cardioplegia in terms of reduced CPB and cross clamp times, lower total volume of cardioplegia." 08/01/2000 - "And cardioplegia technique employed these components improved clinical results of open heart surgery except special cases which require longer cardiac arrest. " 10/01/2022 - "In this study, we treated a rat model of ROSC after cardiac arrest (induced by asphyxiation) with 150 μg/kg BK via intraperitoneal injection 48 hours after ROSC following cardiac arrest. "
5.	Asphyxia (Suffocation) 11/01/2010 - "Neonatal pigs with asphyxia-induced cardiac arrest did not respond to a compression:ventilation ratio of 9:3 better than to 3:1. Future research should address if alternative compression:ventilation ratios offer advantages over the current gold standard of 3:1." 09/23/2023 - "Mechanical chest compression devices may provide improved cardiopulmonary resuscitation outcomes in neonatal and pediatric asphyxia-induced cardiac arrest." 09/23/2023 - "Mechanical CC devices may provide improved cardiopulmonary resuscitation outcomes in neonatal cardiac arrest induced by asphyxia. " 11/01/2021 - "This study aimed to investigate whether NBP can decrease neurological impairment after CA. We studied the protective role of NBP in the hippocampus of a rat model of cardiac arrest induced by asphyxia. " 05/04/2020 - "Adult male Sprague-Dawley rats resuscitated from 10 min of asphyxia-induced cardiac arrest were randomized to four separate experiments including time-course, short-term outcomes, long-term outcomes and mechanism studies. "

Related Drugs and Biologics

1.	Potassium
2.	Solutions
3.	Crystalloid Solutions
4.	Adenosine (Adenocard)
5.	Adenosine Triphosphate (ATP)
6.	Oxygen (Dioxygen)
7.	Calcium
8.	Phosphates (Orthophosphate)
9.	Histidine (L-Histidine)
10.	Cardioplegic Solutions

Related Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass)
2.	Resuscitation
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4.	Therapeutics
5.	Cardiopulmonary Resuscitation (CPR)